Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals

Background High milk intake has been associated with cardio-metabolic risk. We conducted a Mendelian Randomization (MR) study to obtain evidence for the causal relationship between milk consumption and cardio-metabolic traits using the lactase persistence ( LCT -13910 C > T, rs4988235) variant as...

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Veröffentlicht in:	International Journal of Obesity 2021-08, Vol.45 (8), p.1751-1762
Hauptverfasser:	Vimaleswaran, Karani Santhanakrishnan, Zhou, Ang, Cavadino, Alana, Hyppönen, Elina
Format:	Artikel
Sprache:	eng
Schlagworte:	38/43 38/77 692/308/174 692/699/1702 692/700/2814 Alleles Animals Arm Biobanks Birth Cohort Body fat Body mass index Body size Cardiometabolic Risk Factors Cardiovascular disease Cardiovascular diseases Cholesterol Consortia Consumption Coronary artery Coronary artery disease Density Diabetes mellitus (non-insulin dependent) Diet Diet - statistics & numerical data Epidemiology Female Genetic aspects Genotypes Health aspects Health Promotion and Disease Prevention Health risks Heart diseases High density lipoprotein Humans Internal Medicine Lactase Low density lipoprotein Male Medicine Medicine & Public Health Mendelian Randomization Analysis Metabolic Diseases Metabolic Syndrome - epidemiology Metabolism Milk Milk - statistics & numerical data Population studies Population-based studies Public Health Randomization Retirement Risk Risk factors Statistical analysis Statistics Systematic review United Kingdom
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