Effect of Dietary or Supplemental Vitamin C Intake on Vitamin C Levels in Patients with and without Cardiovascular Disease: A Systematic Review
Atherosclerosis is a pro-oxidative and pro-inflammatory disease state, which is the underlying cause of most cardiovascular events, estimated to affect 5.2% of the Australian population. Diet, and specifically vitamin C, through its antioxidant properties can play a role in impeding the development...
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| Veröffentlicht in: | Nutrients 2021-07, Vol.13 (7), p.2330 |
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| creator | Collins, Bianca J Mukherjee, Mitali S Miller, Michelle D Delaney, Christopher L |
| description | Atherosclerosis is a pro-oxidative and pro-inflammatory disease state, which is the underlying cause of most cardiovascular events, estimated to affect 5.2% of the Australian population. Diet, and specifically vitamin C, through its antioxidant properties can play a role in impeding the development and progression of atherosclerosis. This systematic review conducted comprehensive searches in Medline, Emcare, Scopus, PubMed, and Cochrane using key search terms for vitamin C, plasma vitamin C, supplementation, and cardiovascular disease (CVD). The results demonstrated that vitamin C supplementation resulted in a significant increase in vitamin C levels in populations with or without CVD, except for one study on the CVD population. It was also seen that the healthy population baseline and post-intervention vitamin C levels were high compared to the CVD population. However, further research is indicated for CVD population groups with varying baseline vitamin C levels, such as low baseline vitamin C, within a more representative elderly cohort in order to formulate and update vitamin C repletion guidelines. |
| doi_str_mv | 10.3390/nu13072330 |
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Diet, and specifically vitamin C, through its antioxidant properties can play a role in impeding the development and progression of atherosclerosis. This systematic review conducted comprehensive searches in Medline, Emcare, Scopus, PubMed, and Cochrane using key search terms for vitamin C, plasma vitamin C, supplementation, and cardiovascular disease (CVD). The results demonstrated that vitamin C supplementation resulted in a significant increase in vitamin C levels in populations with or without CVD, except for one study on the CVD population. It was also seen that the healthy population baseline and post-intervention vitamin C levels were high compared to the CVD population. However, further research is indicated for CVD population groups with varying baseline vitamin C levels, such as low baseline vitamin C, within a more representative elderly cohort in order to formulate and update vitamin C repletion guidelines.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13072330</identifier><identifier>PMID: 34371840</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Antioxidants ; Arteriosclerosis ; Ascorbic acid ; Atherosclerosis ; Bias ; Cardiovascular disease ; Cardiovascular diseases ; Care and treatment ; Development and progression ; Diet ; Dietary intake ; Inflammatory diseases ; Intervention ; Males ; Mortality ; Population studies ; Review ; Sapropterin dihydrochloride ; Systematic review ; Vitamin C ; Vitamin E</subject><ispartof>Nutrients, 2021-07, Vol.13 (7), p.2330</ispartof><rights>COPYRIGHT 2021 MDPI AG</rights><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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However, further research is indicated for CVD population groups with varying baseline vitamin C levels, such as low baseline vitamin C, within a more representative elderly cohort in order to formulate and update vitamin C repletion guidelines.</description><subject>Antioxidants</subject><subject>Arteriosclerosis</subject><subject>Ascorbic acid</subject><subject>Atherosclerosis</subject><subject>Bias</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Development and progression</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Inflammatory diseases</subject><subject>Intervention</subject><subject>Males</subject><subject>Mortality</subject><subject>Population studies</subject><subject>Review</subject><subject>Sapropterin dihydrochloride</subject><subject>Systematic review</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUtFuFCEUnRiNbWpf_AISX4zJVhgGmPHBZLPW2mQTjVVfyR3m0lJnYAVmm36Fv1zWNrY1XhI4wDnncsmtqpeMHnHe0bd-ZpyqmnP6pNqvC1pI2fCnD_BedZjSJd2Fokry59Ueb7hibUP3q9_H1qLJJFjywWGGeE1CJGfzZjPihD7DSH64DJPzZEVOy_4nkuAfnK1xi2MiBX-B7IoikSuXLwj44Q8IcyYriIMLW0hmHiGWRAkh4TuyJGfXKeNUhIZ8xa3DqxfVMwtjwsO79aD6_vH42-rTYv355HS1XC9MI2he9NgLwwbOGuh6a3nPmVGmoV2nhKixE2BogwoltWwwti5hpAVaZqhrCfygen_ru5n7CQdTHh5h1JvopvIHOoDTj2-8u9DnYatbTlvBeDF4fWcQw68ZU9aTSwbHETyGOelaSEolU6It1Ff_UC_DHH0pr7BEo1TLVXPPOocRtfM2lLxmZ6qXSopWKkZlYR39h1XGgJMzwaN15fyR4M2twMSQUkT7t0ZG9a6D9H0H8Rv447cM</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Collins, Bianca J</creator><creator>Mukherjee, Mitali S</creator><creator>Miller, Michelle D</creator><creator>Delaney, Christopher L</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5636-8427</orcidid></search><sort><creationdate>20210701</creationdate><title>Effect of Dietary or Supplemental Vitamin C Intake on Vitamin C Levels in Patients with and without Cardiovascular Disease: A Systematic Review</title><author>Collins, Bianca J ; 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| subjects | Antioxidants Arteriosclerosis Ascorbic acid Atherosclerosis Bias Cardiovascular disease Cardiovascular diseases Care and treatment Development and progression Diet Dietary intake Inflammatory diseases Intervention Males Mortality Population studies Review Sapropterin dihydrochloride Systematic review Vitamin C Vitamin E |
| title | Effect of Dietary or Supplemental Vitamin C Intake on Vitamin C Levels in Patients with and without Cardiovascular Disease: A Systematic Review |
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