Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer

The Wnt and Hippo pathways are tightly coordinated and understanding their reciprocal regulation may provide a novel therapeutic strategy for cancer. Anti-helminthic niclosamide is an effective inhibitor of Wnt and is now in a phase II trial for advanced colorectal cancer (CRC) patients. We found th...

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Veröffentlicht in:	Cancers 2021-07, Vol.13 (14), p.3437
Hauptverfasser:	Kang, Hee Eun, Seo, Yoojeong, Yun, Jun Seop, Song, Sang Hyun, Han, Dawool, Cho, Eunae Sandra, Cho, Sue Bean, Jeon, Yoon, Lee, Ho, Kim, Hyun Sil, Kang, Joyeon, Yook, Jong In, Kim, Nam Hee, Kim, Tae Il
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli Animal models Cancer Colorectal cancer Colorectal carcinoma Gene expression Kinases Metformin Niclosamide Oral administration Organoids Phosphorylation Polyposis Proteins Tumorigenesis Wnt protein Yes-associated protein
Online-Zugang:	Volltext
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