Blood-Brain Barrier and Neurodegenerative Diseases-Modeling with iPSC-Derived Brain Cells

The blood-brain barrier (BBB) regulates the delivery of oxygen and important nutrients to the brain through active and passive transport and prevents neurotoxins from entering the brain. It also has a clearance function and removes carbon dioxide and toxic metabolites from the central nervous system...

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Veröffentlicht in:	International journal of molecular sciences 2021-07, Vol.22 (14), p.7710
Hauptverfasser:	Wu, Ying-Chieh, Sonninen, Tuuli-Maria, Peltonen, Sanni, Koistinaho, Jari, Lehtonen, Šárka
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Blood-brain barrier Blood-Brain Barrier - cytology Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain Brain - blood supply Brain - cytology Brain - metabolism Carbon dioxide Carbon dioxide removal Cell culture Cell cycle Central nervous system Cerebrovascular Circulation Drug screening Gene expression Growth factors Homeostasis Human influences Humans Immune clearance Immune system Immunosuppressive agents Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology Membrane permeability Metabolites Modelling Models, Biological Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurological diseases Neurotoxins Nutrients Older people Parkinson's disease Pathogens Pathology Permeability Pluripotency Potassium Proteins Review Stem cells Toxins
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