Repetitive aeroallergen challenges elucidate maladaptive epithelial and inflammatory traits that underpin allergic airway diseases

Signifying the 2-compartments/1-disease paradigm, allergic rhinoconjunctivitis (ARC) and asthma (AA) are prevalent, comorbid conditions triggered by environmental factors (eg, house dust mites [HDMs]). However, despite the ubiquity of triggers, progression to severe ARC/AA is infrequent, suggesting...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2021-08, Vol.148 (2), p.533-549
Hauptverfasser:	Smith, Alisha M., Harper, Nathan, Meunier, Justin A., Branum, Anne P., Jimenez, Fabio, Pandranki, Lavanya, Carrillo, Andrew, Dela Cruz, Charles S., Restrepo, Marcos I., Maselli, Diego J., Rather, Cynthia G., Heisser, Anna H., Ramirez, Daniel A., He, Weijing, Clark, Robert A., Andrews, Charles P., Evans, Scott E., Pugh, Jacqueline A., Zhang, Nu, Lee, Grace C., Moreira, Alvaro G., Segal, Leopoldo N., Ramirez, Robert M., Jacobs, Robert L., Manoharan, Muthu Saravanan, Okulicz, Jason F., Ahuja, Sunil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Adult Aeroallergen challenge chamber Allergens - immunology Allergens - toxicity allergic rhinoconjunctivitis Animals Asthma Asthma - immunology Asthma - pathology CD4 antigen CD8 antigen Disease Environmental factors Eosinophils - immunology Eosinophils - pathology evoked phenotypes Female Gene expression Genotype & phenotype house dust mites Humans Inflammation Inflammation - immunology Inflammation - pathology Interferon Leukocytes (eosinophilic) Lymphocytes - immunology Lymphocytes - pathology Lymphocytes T maladaptation Male Mucosa Natural killer cells Peripheral blood Phenotypes Pyroglyphidae Respiratory Mucosa - immunology Respiratory tract diseases Rhinoconjunctivitis Statistical methods
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