Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders
Quadruple aberrant hyperphosphorylated tau (p-τ), amyloid-β peptide, alpha-synuclein and TDP-43 brainstem and supratentorial pathology are documented in forensic ≤40y autopsies in Metropolitan Mexico City (MMC), and p-τ is the major aberrant protein. Post-traumatic stress disorder (PTSD) is associat...
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| Veröffentlicht in: | International journal of environmental research and public health 2021-06, Vol.18 (13), p.6689 |
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| creator | Calderón-Garcidueñas, Lilian Rajkumar, Ravi Philip Stommel, Elijah W Kulesza, Randy Mansour, Yusra Rico-Villanueva, Adriana Flores-Vázquez, Jorge Orlando Brito-Aguilar, Rafael Ramírez-Sánchez, Silvia García-Alonso, Griselda Chávez-Franco, Diana A Luévano-Castro, Samuel C García-Rojas, Edgar Revueltas-Ficachi, Paula Villarreal-Ríos, Rodolfo Mukherjee, Partha S |
| description | Quadruple aberrant hyperphosphorylated tau (p-τ), amyloid-β peptide, alpha-synuclein and TDP-43 brainstem and supratentorial pathology are documented in forensic ≤40y autopsies in Metropolitan Mexico City (MMC), and p-τ is the major aberrant protein. Post-traumatic stress disorder (PTSD) is associated with an elevated risk of subsequent dementia, and rapid eye movement sleep behavior disorder (RBD) is documented in PD, AD, Lewy body dementia and ALS. This study aimed to identify an association between PTSD and potential pRBD in Mexico. An anonymous online survey of 4502 urban college-educated adults, 29.3 ± 10.3 years; MMC, n = 1865; non-MMC, n = 2637, measured PTSD symptoms using the Impact of Event Scale-Revised (IES-R) and pRBD symptoms using the RBD Single-Question. Over 50% of the participants had IES-R scores ≥33 indicating probable PTSD. pRBD was identified in 22.6% of the participants across Mexico and 32.7% in MMC residents with PTSD. MMC subjects with PTSD had an OR 2.6218 [2.5348, 2.7117] of answering yes to the pRBD. PTSD and pRBD were more common in women. This study showed an association between PTSD and pRBD, strengthening the possibility of a connection with misfolded proteinopathies in young urbanites. We need to confirm the RBD diagnosis using an overnight polysomnogram. Mexican women are at high risk for stress and sleep disorders. |
| doi_str_mv | 10.3390/ijerph18136689 |
| format | Article |
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Post-traumatic stress disorder (PTSD) is associated with an elevated risk of subsequent dementia, and rapid eye movement sleep behavior disorder (RBD) is documented in PD, AD, Lewy body dementia and ALS. This study aimed to identify an association between PTSD and potential pRBD in Mexico. An anonymous online survey of 4502 urban college-educated adults, 29.3 ± 10.3 years; MMC, n = 1865; non-MMC, n = 2637, measured PTSD symptoms using the Impact of Event Scale-Revised (IES-R) and pRBD symptoms using the RBD Single-Question. Over 50% of the participants had IES-R scores ≥33 indicating probable PTSD. pRBD was identified in 22.6% of the participants across Mexico and 32.7% in MMC residents with PTSD. MMC subjects with PTSD had an OR 2.6218 [2.5348, 2.7117] of answering yes to the pRBD. PTSD and pRBD were more common in women. This study showed an association between PTSD and pRBD, strengthening the possibility of a connection with misfolded proteinopathies in young urbanites. We need to confirm the RBD diagnosis using an overnight polysomnogram. Mexican women are at high risk for stress and sleep disorders.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph18136689</identifier><identifier>PMID: 34206224</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Air pollution ; alpha-Synuclein - metabolism ; Alzheimer's disease ; Amyloid beta-Peptides ; Autopsies ; Behavior disorders ; Brain research ; Brain Stem ; Dementia ; Dementia disorders ; DNA-Binding Proteins ; Female ; Forensic science ; Humans ; Lewy bodies ; Mental disorders ; Mexico - epidemiology ; Middle class ; Neurodegeneration ; Parkinson's disease ; Pathology ; Post traumatic stress disorder ; Privacy ; Proteins ; Psychological stress ; REM sleep ; REM Sleep Behavior Disorder ; Signs and symptoms ; Sleep ; Sleep disorders ; Synuclein ; Traumatic brain injury ; Urban areas ; β-Amyloid</subject><ispartof>International journal of environmental research and public health, 2021-06, Vol.18 (13), p.6689</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-dd4c92286c49748e2bac90977c778b27d197b21727df7424008a247791f5e0ce3</citedby><cites>FETCH-LOGICAL-c418t-dd4c92286c49748e2bac90977c778b27d197b21727df7424008a247791f5e0ce3</cites><orcidid>0000-0003-1655-3534 ; 0000-0003-2699-7438</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297352/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297352/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34206224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calderón-Garcidueñas, Lilian</creatorcontrib><creatorcontrib>Rajkumar, Ravi Philip</creatorcontrib><creatorcontrib>Stommel, Elijah W</creatorcontrib><creatorcontrib>Kulesza, Randy</creatorcontrib><creatorcontrib>Mansour, Yusra</creatorcontrib><creatorcontrib>Rico-Villanueva, Adriana</creatorcontrib><creatorcontrib>Flores-Vázquez, Jorge Orlando</creatorcontrib><creatorcontrib>Brito-Aguilar, Rafael</creatorcontrib><creatorcontrib>Ramírez-Sánchez, Silvia</creatorcontrib><creatorcontrib>García-Alonso, Griselda</creatorcontrib><creatorcontrib>Chávez-Franco, Diana A</creatorcontrib><creatorcontrib>Luévano-Castro, Samuel C</creatorcontrib><creatorcontrib>García-Rojas, Edgar</creatorcontrib><creatorcontrib>Revueltas-Ficachi, Paula</creatorcontrib><creatorcontrib>Villarreal-Ríos, Rodolfo</creatorcontrib><creatorcontrib>Mukherjee, Partha S</creatorcontrib><title>Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Quadruple aberrant hyperphosphorylated tau (p-τ), amyloid-β peptide, alpha-synuclein and TDP-43 brainstem and supratentorial pathology are documented in forensic ≤40y autopsies in Metropolitan Mexico City (MMC), and p-τ is the major aberrant protein. Post-traumatic stress disorder (PTSD) is associated with an elevated risk of subsequent dementia, and rapid eye movement sleep behavior disorder (RBD) is documented in PD, AD, Lewy body dementia and ALS. This study aimed to identify an association between PTSD and potential pRBD in Mexico. An anonymous online survey of 4502 urban college-educated adults, 29.3 ± 10.3 years; MMC, n = 1865; non-MMC, n = 2637, measured PTSD symptoms using the Impact of Event Scale-Revised (IES-R) and pRBD symptoms using the RBD Single-Question. Over 50% of the participants had IES-R scores ≥33 indicating probable PTSD. pRBD was identified in 22.6% of the participants across Mexico and 32.7% in MMC residents with PTSD. MMC subjects with PTSD had an OR 2.6218 [2.5348, 2.7117] of answering yes to the pRBD. PTSD and pRBD were more common in women. This study showed an association between PTSD and pRBD, strengthening the possibility of a connection with misfolded proteinopathies in young urbanites. We need to confirm the RBD diagnosis using an overnight polysomnogram. Mexican women are at high risk for stress and sleep disorders.</description><subject>Adult</subject><subject>Air pollution</subject><subject>alpha-Synuclein - metabolism</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Peptides</subject><subject>Autopsies</subject><subject>Behavior disorders</subject><subject>Brain research</subject><subject>Brain Stem</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>DNA-Binding Proteins</subject><subject>Female</subject><subject>Forensic science</subject><subject>Humans</subject><subject>Lewy bodies</subject><subject>Mental disorders</subject><subject>Mexico - epidemiology</subject><subject>Middle class</subject><subject>Neurodegeneration</subject><subject>Parkinson's disease</subject><subject>Pathology</subject><subject>Post traumatic stress disorder</subject><subject>Privacy</subject><subject>Proteins</subject><subject>Psychological stress</subject><subject>REM sleep</subject><subject>REM Sleep Behavior Disorder</subject><subject>Signs and symptoms</subject><subject>Sleep</subject><subject>Sleep disorders</subject><subject>Synuclein</subject><subject>Traumatic brain injury</subject><subject>Urban areas</subject><subject>β-Amyloid</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU1r3DAQhk1padK01x6LoJce1om-1pIuhc1Hk0KgKZuehSzPxlpky5XkgH9E_3O8zQdJDoMG5pkHDW9RfCb4kDGFj9wW4tASSVhVSfWm2CdVhUteYfL2Wb9XfEhpizGTvFLviz3GKa4o5fvFv-NoXJ8ydOj3aJo4Dh7QqoYYTZ_RxTTs9CHNFSdvMjTo2owLdAzZlKtu8sE1C7TyQ2vK9dSP1oPrkeln7PSq5AxdmdwGH26mBVrnCCn9H649wDBLWnPrQkSnLoXYQEwfi3cb4xN8engPij8_zq5PLsrLX-c_T1aXpeVE5rJpuFWUyspyJbgEWhursBLCCiFrKhqiRE2JmLuN4JRjLA3lQiiyWQK2wA6K7_feYaw7aCz0ORqvh-g6EycdjNMvJ71r9U241ZIqwZZ0Fnx7EMTwd4SUdeeSBe9ND2FMmi65ZEqqSs3o11foNoyxn8_bUYpxwcRypg7vKRtDShE2T58hWO-S1i-Tnhe-PD_hCX-Mlt0BgPqmdg</recordid><startdate>20210622</startdate><enddate>20210622</enddate><creator>Calderón-Garcidueñas, Lilian</creator><creator>Rajkumar, Ravi Philip</creator><creator>Stommel, Elijah W</creator><creator>Kulesza, Randy</creator><creator>Mansour, Yusra</creator><creator>Rico-Villanueva, Adriana</creator><creator>Flores-Vázquez, Jorge Orlando</creator><creator>Brito-Aguilar, Rafael</creator><creator>Ramírez-Sánchez, Silvia</creator><creator>García-Alonso, Griselda</creator><creator>Chávez-Franco, Diana A</creator><creator>Luévano-Castro, Samuel C</creator><creator>García-Rojas, Edgar</creator><creator>Revueltas-Ficachi, Paula</creator><creator>Villarreal-Ríos, Rodolfo</creator><creator>Mukherjee, Partha S</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1655-3534</orcidid><orcidid>https://orcid.org/0000-0003-2699-7438</orcidid></search><sort><creationdate>20210622</creationdate><title>Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders</title><author>Calderón-Garcidueñas, Lilian ; Rajkumar, Ravi Philip ; Stommel, Elijah W ; Kulesza, Randy ; Mansour, Yusra ; Rico-Villanueva, Adriana ; Flores-Vázquez, Jorge Orlando ; Brito-Aguilar, Rafael ; Ramírez-Sánchez, Silvia ; García-Alonso, Griselda ; Chávez-Franco, Diana A ; Luévano-Castro, Samuel C ; García-Rojas, Edgar ; Revueltas-Ficachi, Paula ; Villarreal-Ríos, Rodolfo ; Mukherjee, Partha S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-dd4c92286c49748e2bac90977c778b27d197b21727df7424008a247791f5e0ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Air pollution</topic><topic>alpha-Synuclein - 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Post-traumatic stress disorder (PTSD) is associated with an elevated risk of subsequent dementia, and rapid eye movement sleep behavior disorder (RBD) is documented in PD, AD, Lewy body dementia and ALS. This study aimed to identify an association between PTSD and potential pRBD in Mexico. An anonymous online survey of 4502 urban college-educated adults, 29.3 ± 10.3 years; MMC, n = 1865; non-MMC, n = 2637, measured PTSD symptoms using the Impact of Event Scale-Revised (IES-R) and pRBD symptoms using the RBD Single-Question. Over 50% of the participants had IES-R scores ≥33 indicating probable PTSD. pRBD was identified in 22.6% of the participants across Mexico and 32.7% in MMC residents with PTSD. MMC subjects with PTSD had an OR 2.6218 [2.5348, 2.7117] of answering yes to the pRBD. PTSD and pRBD were more common in women. This study showed an association between PTSD and pRBD, strengthening the possibility of a connection with misfolded proteinopathies in young urbanites. We need to confirm the RBD diagnosis using an overnight polysomnogram. Mexican women are at high risk for stress and sleep disorders.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34206224</pmid><doi>10.3390/ijerph18136689</doi><orcidid>https://orcid.org/0000-0003-1655-3534</orcidid><orcidid>https://orcid.org/0000-0003-2699-7438</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Adult Air pollution alpha-Synuclein - metabolism Alzheimer's disease Amyloid beta-Peptides Autopsies Behavior disorders Brain research Brain Stem Dementia Dementia disorders DNA-Binding Proteins Female Forensic science Humans Lewy bodies Mental disorders Mexico - epidemiology Middle class Neurodegeneration Parkinson's disease Pathology Post traumatic stress disorder Privacy Proteins Psychological stress REM sleep REM Sleep Behavior Disorder Signs and symptoms Sleep Sleep disorders Synuclein Traumatic brain injury Urban areas β-Amyloid |
| title | Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders |
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