Dynamic Behavior of DNA Base Pairs Containing 8-Oxoguanine

The process by which DNA repair enzymes recognize and selectively excise damaged bases in duplex DNA is fundamental to our mechanistic understanding of these critical biological reactions. 8-Oxoguanine (8-oxoG) is the most common form of oxidative DNA damage; unrepaired, this lesion generates a G:C→...

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Veröffentlicht in:	Journal of the American Chemical Society 2005-10, Vol.127 (40), p.13906-13918
Hauptverfasser:	Cheng, Xiaolin, Kelso, Catherine, Hornak, Viktor, de los Santos, Carlos, Grollman, Arthur P, Simmerling, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pairing Biological and medical sciences Conformational dynamics in molecular biology DNA - chemistry Fundamental and applied biological sciences. Psychology Guanine - analogs & derivatives Guanine - chemistry Models, Chemical Molecular biophysics Thermodynamics Time Factors
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