Characteristics of taste alterations in people receiving taxane-based chemotherapy and their association with appetite, weight, and quality of life
Purpose There is limited evidence on the effect of chemotherapy-associated taste alteration. This study aimed to evaluate taste alteration characteristics in patients receiving taxane-based chemotherapy and investigate the association of taste alterations with appetite, weight, quality of life (QOL)...
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| Veröffentlicht in: | Supportive care in cancer 2021-09, Vol.29 (9), p.5103-5114 |
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| creator | Kaizu, Mikiko Komatsu, Hiroko Yamauchi, Hideko Yamauchi, Teruo Sumitani, Masahiko Doorenbos, Ardith Z |
| description | Purpose
There is limited evidence on the effect of chemotherapy-associated taste alteration. This study aimed to evaluate taste alteration characteristics in patients receiving taxane-based chemotherapy and investigate the association of taste alterations with appetite, weight, quality of life (QOL), and adverse events.
Methods
This cross-sectional study evaluated 100 patients receiving paclitaxel, docetaxel, or nab-paclitaxel as monotherapy or combination therapy. Taste alterations were evaluated using taste recognition thresholds and severity and symptom scales. Taste recognition thresholds, symptoms, appetite, weight, and adverse events were compared between patients with and without taste alterations, and logistic regression analysis was performed to identify risk factors.
Results
Of the 100 patients, 59% reported taste alterations. We found significantly elevated taste recognition thresholds (hypogeusia) for sweet, sour, and bitter tastes in the taste alteration group receiving nab-paclitaxel (
p
= 0.022, 0.020, and 0.039, respectively). The taste alteration group reported general taste alterations, decline in basic taste, and decreased appetite. Neither weight nor QOL was associated with taste alterations. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were significantly associated with taste alterations.
Conclusions
Almost 60% of patients receiving taxane-based regimens, especially docetaxel, reported taste alterations. Taste alteration affected the patient’s appetite but did not affect the weight or QOL. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were independent risk factors for taste alterations. |
| doi_str_mv | 10.1007/s00520-021-06066-3 |
| format | Article |
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There is limited evidence on the effect of chemotherapy-associated taste alteration. This study aimed to evaluate taste alteration characteristics in patients receiving taxane-based chemotherapy and investigate the association of taste alterations with appetite, weight, quality of life (QOL), and adverse events.
Methods
This cross-sectional study evaluated 100 patients receiving paclitaxel, docetaxel, or nab-paclitaxel as monotherapy or combination therapy. Taste alterations were evaluated using taste recognition thresholds and severity and symptom scales. Taste recognition thresholds, symptoms, appetite, weight, and adverse events were compared between patients with and without taste alterations, and logistic regression analysis was performed to identify risk factors.
Results
Of the 100 patients, 59% reported taste alterations. We found significantly elevated taste recognition thresholds (hypogeusia) for sweet, sour, and bitter tastes in the taste alteration group receiving nab-paclitaxel (
p
= 0.022, 0.020, and 0.039, respectively). The taste alteration group reported general taste alterations, decline in basic taste, and decreased appetite. Neither weight nor QOL was associated with taste alterations. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were significantly associated with taste alterations.
Conclusions
Almost 60% of patients receiving taxane-based regimens, especially docetaxel, reported taste alterations. Taste alteration affected the patient’s appetite but did not affect the weight or QOL. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were independent risk factors for taste alterations.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-021-06066-3</identifier><identifier>PMID: 33604787</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Appetite ; Cancer ; Chemotherapy ; Comparative analysis ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Nursing ; Nursing Research ; Oncology ; Original ; Original Article ; Pain Medicine ; Peripheral neuropathy ; Quality of life ; Rehabilitation Medicine ; Sensory perception ; Side effects ; Taste ; Weight</subject><ispartof>Supportive care in cancer, 2021-09, Vol.29 (9), p.5103-5114</ispartof><rights>The Author(s) 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-bcd8ba43116c591e5960ece3f34db7cbdd3f50dd84ca43c078ce6c27e7953eb83</citedby><cites>FETCH-LOGICAL-c541t-bcd8ba43116c591e5960ece3f34db7cbdd3f50dd84ca43c078ce6c27e7953eb83</cites><orcidid>0000-0002-2669-8916</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-021-06066-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-021-06066-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33604787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaizu, Mikiko</creatorcontrib><creatorcontrib>Komatsu, Hiroko</creatorcontrib><creatorcontrib>Yamauchi, Hideko</creatorcontrib><creatorcontrib>Yamauchi, Teruo</creatorcontrib><creatorcontrib>Sumitani, Masahiko</creatorcontrib><creatorcontrib>Doorenbos, Ardith Z</creatorcontrib><title>Characteristics of taste alterations in people receiving taxane-based chemotherapy and their association with appetite, weight, and quality of life</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
There is limited evidence on the effect of chemotherapy-associated taste alteration. This study aimed to evaluate taste alteration characteristics in patients receiving taxane-based chemotherapy and investigate the association of taste alterations with appetite, weight, quality of life (QOL), and adverse events.
Methods
This cross-sectional study evaluated 100 patients receiving paclitaxel, docetaxel, or nab-paclitaxel as monotherapy or combination therapy. Taste alterations were evaluated using taste recognition thresholds and severity and symptom scales. Taste recognition thresholds, symptoms, appetite, weight, and adverse events were compared between patients with and without taste alterations, and logistic regression analysis was performed to identify risk factors.
Results
Of the 100 patients, 59% reported taste alterations. We found significantly elevated taste recognition thresholds (hypogeusia) for sweet, sour, and bitter tastes in the taste alteration group receiving nab-paclitaxel (
p
= 0.022, 0.020, and 0.039, respectively). The taste alteration group reported general taste alterations, decline in basic taste, and decreased appetite. Neither weight nor QOL was associated with taste alterations. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were significantly associated with taste alterations.
Conclusions
Almost 60% of patients receiving taxane-based regimens, especially docetaxel, reported taste alterations. Taste alteration affected the patient’s appetite but did not affect the weight or QOL. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were independent risk factors for taste alterations.</description><subject>Appetite</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Comparative analysis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Peripheral neuropathy</subject><subject>Quality of life</subject><subject>Rehabilitation Medicine</subject><subject>Sensory perception</subject><subject>Side effects</subject><subject>Taste</subject><subject>Weight</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9Us1u1DAQjhCIbgsvwAFZ4sKhKXZsx8kFqVpRQKrEBc6W40wSV4md2k7bfQ5eGGe3tBQh5IOtme_HM_qy7A3BZwRj8SFgzAuc44LkuMRlmdNn2YYwSnNBaf082-CakZxRzo-y4xCuMCZC8OJldkRpiZmoxCb7uR2UVzqCNyEaHZDrUFQhAlJjKqponA3IWDSDm0dAHjSYG2P7hLpTFvJGBWiRHmBycUiEeYeUbVF6G49UCE6bvQi6NXFAap4hmgin6BZMP8TTPfh6UaOJu9V7NB28yl50agzw-v4-yX5cfPq-_ZJffvv8dXt-mWvOSMwb3VaNYpSQUvOaAK9LnH5HO8raRuimbWnHcdtWTCeUxqLSUOpCgKg5haaiJ9nHg-68NBO0Gmz0apSzN5PyO-mUkU871gyydzeyKmqOyzoJvL8X8O56gRDlZIKGcUyLcUuQBatJ8sL16vXuL-iVW7xN48mCc1qSqmL4EdWrEaSxnUu-ehWV52UyJIKyVevsH6h0WpiMdhY6k-pPCMWBoL0LwUP3MCPBco2SPERJpijJfZQkTaS3f27ngfI7OwlAD4CQWrYH_zjSf2R_AUFy10w</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Kaizu, Mikiko</creator><creator>Komatsu, Hiroko</creator><creator>Yamauchi, Hideko</creator><creator>Yamauchi, Teruo</creator><creator>Sumitani, Masahiko</creator><creator>Doorenbos, Ardith Z</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2669-8916</orcidid></search><sort><creationdate>20210901</creationdate><title>Characteristics of taste alterations in people receiving taxane-based chemotherapy and their association with appetite, weight, and quality of life</title><author>Kaizu, Mikiko ; Komatsu, Hiroko ; Yamauchi, Hideko ; Yamauchi, Teruo ; Sumitani, Masahiko ; Doorenbos, Ardith Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-bcd8ba43116c591e5960ece3f34db7cbdd3f50dd84ca43c078ce6c27e7953eb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Appetite</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Comparative analysis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Peripheral neuropathy</topic><topic>Quality of life</topic><topic>Rehabilitation Medicine</topic><topic>Sensory perception</topic><topic>Side effects</topic><topic>Taste</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaizu, Mikiko</creatorcontrib><creatorcontrib>Komatsu, Hiroko</creatorcontrib><creatorcontrib>Yamauchi, Hideko</creatorcontrib><creatorcontrib>Yamauchi, Teruo</creatorcontrib><creatorcontrib>Sumitani, Masahiko</creatorcontrib><creatorcontrib>Doorenbos, Ardith Z</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaizu, Mikiko</au><au>Komatsu, Hiroko</au><au>Yamauchi, Hideko</au><au>Yamauchi, Teruo</au><au>Sumitani, Masahiko</au><au>Doorenbos, Ardith Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of taste alterations in people receiving taxane-based chemotherapy and their association with appetite, weight, and quality of life</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>29</volume><issue>9</issue><spage>5103</spage><epage>5114</epage><pages>5103-5114</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
There is limited evidence on the effect of chemotherapy-associated taste alteration. This study aimed to evaluate taste alteration characteristics in patients receiving taxane-based chemotherapy and investigate the association of taste alterations with appetite, weight, quality of life (QOL), and adverse events.
Methods
This cross-sectional study evaluated 100 patients receiving paclitaxel, docetaxel, or nab-paclitaxel as monotherapy or combination therapy. Taste alterations were evaluated using taste recognition thresholds and severity and symptom scales. Taste recognition thresholds, symptoms, appetite, weight, and adverse events were compared between patients with and without taste alterations, and logistic regression analysis was performed to identify risk factors.
Results
Of the 100 patients, 59% reported taste alterations. We found significantly elevated taste recognition thresholds (hypogeusia) for sweet, sour, and bitter tastes in the taste alteration group receiving nab-paclitaxel (
p
= 0.022, 0.020, and 0.039, respectively). The taste alteration group reported general taste alterations, decline in basic taste, and decreased appetite. Neither weight nor QOL was associated with taste alterations. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were significantly associated with taste alterations.
Conclusions
Almost 60% of patients receiving taxane-based regimens, especially docetaxel, reported taste alterations. Taste alteration affected the patient’s appetite but did not affect the weight or QOL. Docetaxel therapy, previous chemotherapy, dry mouth, and peripheral neuropathy were independent risk factors for taste alterations.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33604787</pmid><doi>10.1007/s00520-021-06066-3</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-2669-8916</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Supportive care in cancer, 2021-09, Vol.29 (9), p.5103-5114 |
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| subjects | Appetite Cancer Chemotherapy Comparative analysis Medical research Medicine Medicine & Public Health Medicine, Experimental Nursing Nursing Research Oncology Original Original Article Pain Medicine Peripheral neuropathy Quality of life Rehabilitation Medicine Sensory perception Side effects Taste Weight |
| title | Characteristics of taste alterations in people receiving taxane-based chemotherapy and their association with appetite, weight, and quality of life |
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