Histone Methyltransferase G9a Promotes the Development of Renal Cancer through Epigenetic Silencing of Tumor Suppressor Gene SPINK5

Background. Renal cell carcinoma (RCC) accounts for approximately 2–3% of malignant tumors in adults, while clear cell renal cell carcinoma accounts for 70–85% of kidney cancer cases, with an increasing incidence worldwide. G9a is the second histone methyltransferase found in mammals, catalyzing lys...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.6650781-6650781
Hauptverfasser:	Li, Ren-Gui, Deng, Huan, Liu, Xiu-Heng, Chen, Zhi-yuan, Wan, Shan-shan, Wang, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Apoptosis Bioinformatics Cell Line, Tumor Cell Proliferation DNA methylation Epigenesis, Genetic - genetics Epigenetics Ethics Experiments Flow cytometry Gene expression Genes, Tumor Suppressor - physiology Histone-Lysine N-Methyltransferase - adverse effects Humans Infrared imaging systems Kidney cancer Kidney Neoplasms - genetics Metastasis Mice Mice, Nude Proteins Software Tumorigenesis Tumors Xenograft Model Antitumor Assays
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