PINK1‐induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension

Impaired mitochondrial fusion, due in part to decreased mitofusin 2 (Mfn2) expression, contributes to unrestricted cell proliferation and apoptosis‐resistance in hyperproliferative diseases like pulmonary arterial hypertension (PAH) and non‐small cell lung cancer (NSCLC). We hypothesized that Mfn2 l...

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Veröffentlicht in:	The FASEB journal 2021-08, Vol.35 (8), p.e21771-n/a
Hauptverfasser:	Dasgupta, Asish, Chen, Kuang‐Hueih, Lima, Patricia D. A., Mewburn, Jeffrey, Wu, Danchen, Al‐Qazazi, Ruaa, Jones, Oliver, Tian, Lian, Potus, Francois, Bonnet, Sebastien, Archer, Stephen L.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenoviral gene therapy mitochondrial dynamics non‐small cell lung cancer (NSCLC) phosphatase and tensin homolog (PTEN)‐induced putative kinase 1 (PINK1) protein kinase A (PKA)
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