A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation

Mitochondrial dysfunction is an underlying pathology in numerous diseases. Delivery of diagnostic and therapeutic cargo directly into mitochondria is a powerful approach to study and treat these diseases. The triphenylphosphonium (TPP+) moiety is the most widely used mitochondriotropic carrier. Howe...

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Veröffentlicht in:	Journal of medicinal chemistry 2021-01, Vol.64 (1), p.662-676
Hauptverfasser:	Kulkarni, Chaitanya A, Fink, Brian D, Gibbs, Bettine E, Chheda, Pratik R, Wu, Meng, Sivitz, William I, Kerns, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival - drug effects Chromatography, High Pressure Liquid Drug Carriers Humans Mitochondria - drug effects Mitochondria - metabolism Organophosphorus Compounds - metabolism Organophosphorus Compounds - pharmacology Oxidative Phosphorylation
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