Anxiety and Alzheimer’s disease: Behavioral analysis and neural basis in rodent models of Alzheimer’s-related neuropathology
•Human Alzheimer’s patients exhibit anxiety at the mild cognitive impairment stage of the disease, which is associated with an increased likelihood of developing dementia.•Transgenic rodent models of Alzheimer’s disease exhibit inconsistent markers of anxiety.•We suggest that future research will be...
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Veröffentlicht in: | Neuroscience and biobehavioral reviews 2021-08, Vol.127, p.647-658 |
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creator | Pentkowski, Nathan S. Rogge-Obando, Kimberly K. Donaldson, Tia N. Bouquin, Samuel J. Clark, Benjamin J. |
description | •Human Alzheimer’s patients exhibit anxiety at the mild cognitive impairment stage of the disease, which is associated with an increased likelihood of developing dementia.•Transgenic rodent models of Alzheimer’s disease exhibit inconsistent markers of anxiety.•We suggest that future research will benefit from using a battery of tests to examine anxiety-like and emotional behavior in transgenic AD models.
Alzheimer’s disease (AD) pathology is commonly associated with cognitive decline but is also composed of neuropsychiatric symptoms including psychological distress and alterations in mood, including anxiety and depression. Emotional dysfunction in AD is frequently modeled using tests of anxiety-like behavior in transgenic rodents. These tests often include the elevated plus-maze, light/dark test and open field test. In this review, we describe prototypical behavioral paradigms used to examine emotional dysfunction in transgenic models of AD, specifically anxiety-like behavior. Next, we summarize the results of studies examining anxiety-like behavior in transgenic rodents, noting that the behavioral outcomes using these paradigms have produced inconsistent results. We suggest that future research will benefit from using a battery of tests to examine emotional behavior in transgenic AD models. We conclude by discussing putative, overlapping neurobiological mechanisms underlying AD-related neuropathology, stress and anxiety-like behavior reported in AD models. |
doi_str_mv | 10.1016/j.neubiorev.2021.05.005 |
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Alzheimer’s disease (AD) pathology is commonly associated with cognitive decline but is also composed of neuropsychiatric symptoms including psychological distress and alterations in mood, including anxiety and depression. Emotional dysfunction in AD is frequently modeled using tests of anxiety-like behavior in transgenic rodents. These tests often include the elevated plus-maze, light/dark test and open field test. In this review, we describe prototypical behavioral paradigms used to examine emotional dysfunction in transgenic models of AD, specifically anxiety-like behavior. Next, we summarize the results of studies examining anxiety-like behavior in transgenic rodents, noting that the behavioral outcomes using these paradigms have produced inconsistent results. We suggest that future research will benefit from using a battery of tests to examine emotional behavior in transgenic AD models. We conclude by discussing putative, overlapping neurobiological mechanisms underlying AD-related neuropathology, stress and anxiety-like behavior reported in AD models.</description><identifier>ISSN: 0149-7634</identifier><identifier>EISSN: 1873-7528</identifier><identifier>DOI: 10.1016/j.neubiorev.2021.05.005</identifier><identifier>PMID: 33979573</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Alzheimer’s disease ; Anxiety ; Elevated plus-maze ; light/dark test ; Open field ; Stress ; Ventral hippocampus</subject><ispartof>Neuroscience and biobehavioral reviews, 2021-08, Vol.127, p.647-658</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-eeac424307e2323fe0403e339920d55f226b1dfb3e6d1430f8a9cb625a3068c93</citedby><cites>FETCH-LOGICAL-c475t-eeac424307e2323fe0403e339920d55f226b1dfb3e6d1430f8a9cb625a3068c93</cites><orcidid>0000-0003-4997-0385</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neubiorev.2021.05.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33979573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pentkowski, Nathan S.</creatorcontrib><creatorcontrib>Rogge-Obando, Kimberly K.</creatorcontrib><creatorcontrib>Donaldson, Tia N.</creatorcontrib><creatorcontrib>Bouquin, Samuel J.</creatorcontrib><creatorcontrib>Clark, Benjamin J.</creatorcontrib><title>Anxiety and Alzheimer’s disease: Behavioral analysis and neural basis in rodent models of Alzheimer’s-related neuropathology</title><title>Neuroscience and biobehavioral reviews</title><addtitle>Neurosci Biobehav Rev</addtitle><description>•Human Alzheimer’s patients exhibit anxiety at the mild cognitive impairment stage of the disease, which is associated with an increased likelihood of developing dementia.•Transgenic rodent models of Alzheimer’s disease exhibit inconsistent markers of anxiety.•We suggest that future research will benefit from using a battery of tests to examine anxiety-like and emotional behavior in transgenic AD models.
Alzheimer’s disease (AD) pathology is commonly associated with cognitive decline but is also composed of neuropsychiatric symptoms including psychological distress and alterations in mood, including anxiety and depression. Emotional dysfunction in AD is frequently modeled using tests of anxiety-like behavior in transgenic rodents. These tests often include the elevated plus-maze, light/dark test and open field test. In this review, we describe prototypical behavioral paradigms used to examine emotional dysfunction in transgenic models of AD, specifically anxiety-like behavior. Next, we summarize the results of studies examining anxiety-like behavior in transgenic rodents, noting that the behavioral outcomes using these paradigms have produced inconsistent results. We suggest that future research will benefit from using a battery of tests to examine emotional behavior in transgenic AD models. We conclude by discussing putative, overlapping neurobiological mechanisms underlying AD-related neuropathology, stress and anxiety-like behavior reported in AD models.</description><subject>Alzheimer’s disease</subject><subject>Anxiety</subject><subject>Elevated plus-maze</subject><subject>light/dark test</subject><subject>Open field</subject><subject>Stress</subject><subject>Ventral hippocampus</subject><issn>0149-7634</issn><issn>1873-7528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkU2O1DAQhS0EYpqBK0CWbBLK5Tg_LJCaEX_SSGxgbTlOZdotJ27sdItmNdfgepwEhx5azIpVSeWvXr3yY-wFh4IDr15ti4n2nfWBDgUC8gJkASAfsBVvapHXEpuHbAW8bPO6EuUFexLjFgAQhHzMLoRo61bWYsVu19N3S_Mx01Ofrd2PDdmRwq_bnzHrbSQd6XX2ljb6kHZplyjtjtHGP3iysPQ6vTTslAXf0zRnYyouZn64r5cHcnqm05jf6Xnjnb85PmWPBu0iPburl-zr-3dfrj7m158_fLpaX-emrOWcE2lTYimgJhQoBoISBKU7WoReygGx6ng_dIKqnidsaHRrugqlFlA1phWX7M1Jd7fvRupNcprMq12wow5H5bVV918mu1E3_qAabBFxEXh5JxD8tz3FWY02GnJOT-T3UaHESoAQiAmtT6gJPsZAw3kNB7Xkp7bqnJ9a8lMgVcovTT7_1-V57m9gCVifgPTFdLAUVDSWJkO9DWRm1Xv73yW_AS37tkY</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Pentkowski, Nathan S.</creator><creator>Rogge-Obando, Kimberly K.</creator><creator>Donaldson, Tia N.</creator><creator>Bouquin, Samuel J.</creator><creator>Clark, Benjamin J.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4997-0385</orcidid></search><sort><creationdate>20210801</creationdate><title>Anxiety and Alzheimer’s disease: Behavioral analysis and neural basis in rodent models of Alzheimer’s-related neuropathology</title><author>Pentkowski, Nathan S. ; Rogge-Obando, Kimberly K. ; Donaldson, Tia N. ; Bouquin, Samuel J. ; Clark, Benjamin J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-eeac424307e2323fe0403e339920d55f226b1dfb3e6d1430f8a9cb625a3068c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alzheimer’s disease</topic><topic>Anxiety</topic><topic>Elevated plus-maze</topic><topic>light/dark test</topic><topic>Open field</topic><topic>Stress</topic><topic>Ventral hippocampus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pentkowski, Nathan S.</creatorcontrib><creatorcontrib>Rogge-Obando, Kimberly K.</creatorcontrib><creatorcontrib>Donaldson, Tia N.</creatorcontrib><creatorcontrib>Bouquin, Samuel J.</creatorcontrib><creatorcontrib>Clark, Benjamin J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience and biobehavioral reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pentkowski, Nathan S.</au><au>Rogge-Obando, Kimberly K.</au><au>Donaldson, Tia N.</au><au>Bouquin, Samuel J.</au><au>Clark, Benjamin J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anxiety and Alzheimer’s disease: Behavioral analysis and neural basis in rodent models of Alzheimer’s-related neuropathology</atitle><jtitle>Neuroscience and biobehavioral reviews</jtitle><addtitle>Neurosci Biobehav Rev</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>127</volume><spage>647</spage><epage>658</epage><pages>647-658</pages><issn>0149-7634</issn><eissn>1873-7528</eissn><abstract>•Human Alzheimer’s patients exhibit anxiety at the mild cognitive impairment stage of the disease, which is associated with an increased likelihood of developing dementia.•Transgenic rodent models of Alzheimer’s disease exhibit inconsistent markers of anxiety.•We suggest that future research will benefit from using a battery of tests to examine anxiety-like and emotional behavior in transgenic AD models.
Alzheimer’s disease (AD) pathology is commonly associated with cognitive decline but is also composed of neuropsychiatric symptoms including psychological distress and alterations in mood, including anxiety and depression. Emotional dysfunction in AD is frequently modeled using tests of anxiety-like behavior in transgenic rodents. These tests often include the elevated plus-maze, light/dark test and open field test. In this review, we describe prototypical behavioral paradigms used to examine emotional dysfunction in transgenic models of AD, specifically anxiety-like behavior. Next, we summarize the results of studies examining anxiety-like behavior in transgenic rodents, noting that the behavioral outcomes using these paradigms have produced inconsistent results. We suggest that future research will benefit from using a battery of tests to examine emotional behavior in transgenic AD models. We conclude by discussing putative, overlapping neurobiological mechanisms underlying AD-related neuropathology, stress and anxiety-like behavior reported in AD models.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>33979573</pmid><doi>10.1016/j.neubiorev.2021.05.005</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4997-0385</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Alzheimer’s disease Anxiety Elevated plus-maze light/dark test Open field Stress Ventral hippocampus |
title | Anxiety and Alzheimer’s disease: Behavioral analysis and neural basis in rodent models of Alzheimer’s-related neuropathology |
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