Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells

In vivo models that recapitulate human erythropoiesis with persistence of circulating red blood cells (RBCs) have remained elusive. We report an immunodeficient murine model in which combined human liver and cytokine humanization confer enhanced human erythropoiesis and RBC survival in the circulati...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-03, Vol.371 (6533), p.1019-1025
Hauptverfasser:	Song, Yuanbin, Shan, Liang, Gbyli, Rana, Liu, Wei, Strowig, Till, Patel, Amisha, Fu, Xiaoying, Wang, Xiaman, Xu, Mina L, Gao, Yimeng, Qin, Ashley, Bruscia, Emanuela M, Tebaldi, Toma, Biancon, Giulia, Mamillapalli, Padmavathi, Urbonas, David, Eynon, Elizabeth, Gonzalez, David G, Chen, Jie, Krause, Diane S, Alderman, Jonathan, Halene, Stephanie, Flavell, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Sickle Cell - blood Animal models Animals Blood Blood Circulation Bone marrow Cell density Complement component C3 CRISPR Cytokines Cytokines - metabolism Disease Models, Animal Erythrocytes Erythrocytes - cytology Erythropoiesis Erythropoiesis - genetics Erythropoiesis - physiology Female Fetuses Fumarylacetoacetase Gene Deletion Genetic engineering Hematopoiesis Hematopoietic Stem Cells - cytology Hepatocytes Humanization Humans Hydrolases - genetics Immunodeficiency In vivo methods and tests Infectious diseases Liver Liver - physiology Liver transplantation Malaria Mice Mice, Mutant Strains Middle Aged Occlusion Pathology Sickle cell disease Stem cell transplantation Stem cells Survival Vector-borne diseases
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