Progression of vertebral bone disease in mucopolysaccharidosis VII dogs from birth to skeletal maturity

Mucopolysaccharidosis (MPS) VII is a lysosomal storage disorder characterized by deficient β-glucuronidase activity, leading to accumulation of incompletely degraded heparan, dermatan and chondroitin sulfate glycosaminoglycans. Patients with MPS VII exhibit progressive spinal deformity, which decrea...

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Veröffentlicht in:	Molecular genetics and metabolism 2021-08, Vol.133 (4), p.378-385
Hauptverfasser:	Peck, Sun H., Lau, Yian Khai, Kang, Jennifer L., Lin, Megan, Arginteanu, Toren, Matalon, Dena R., Bendigo, Justin R., O'Donnell, Patricia, Haskins, Mark E., Casal, Margret L., Smith, Lachlan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biomarker Bone and Bones - pathology Bone Diseases - genetics Bone Diseases - physiopathology Canine Disease Progression Dogs Female Growth and Development Growth plate Lysosomal storage disease Male Mucopolysaccharidosis Mucopolysaccharidosis VII - complications Mucopolysaccharidosis VII - genetics Osteogenesis Spine Spine - pathology
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