Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases
The aging of population has become an issue of great concern because of its rapid increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed vario...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.9932218-9932218 |
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| container_title | Oxidative medicine and cellular longevity |
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| creator | Zhou, Dan-Dan Luo, Min Huang, Si-Yu Saimaiti, Adila Shang, Ao Gan, Ren-You Li, Hua-Bin |
| description | The aging of population has become an issue of great concern because of its rapid increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, such as antioxidant, anti-inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, and antiaging effects. The antiaging mechanisms of resveratrol were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol could be an effective and safe compound for the prevention and treatment of aging and age-related diseases. In this review, we summarize the effects of resveratrol on aging, life extension, and several age-related diseases, with special attention paid to the mechanisms of antiaging action. |
| doi_str_mv | 10.1155/2021/9932218 |
| format | Article |
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Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, such as antioxidant, anti-inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, and antiaging effects. The antiaging mechanisms of resveratrol were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol could be an effective and safe compound for the prevention and treatment of aging and age-related diseases. In this review, we summarize the effects of resveratrol on aging, life extension, and several age-related diseases, with special attention paid to the mechanisms of antiaging action.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2021/9932218</identifier><identifier>PMID: 34336123</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Age ; Aging ; Aging - drug effects ; Animal cognition ; Animals ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Apoptosis ; Autophagy ; Cell culture ; Cognitive ability ; Diet ; Dopamine ; Humans ; Inflammation ; Insects ; Kinases ; Memory ; Microbiota ; Nematodes ; Neurodegeneration ; Neurogenesis ; Oral administration ; Oxidative stress ; Population ; Resveratrol - pharmacology ; Resveratrol - therapeutic use ; Review ; Sarcopenia ; Senescence ; Tumors</subject><ispartof>Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.9932218-9932218</ispartof><rights>Copyright © 2021 Dan-Dan Zhou et al.</rights><rights>Copyright © 2021 Dan-Dan Zhou et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Dan-Dan Zhou et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-d6e3bd7cc78b0c55087898608bbd8f156346adbeead605dbef814c13b0919feb3</citedby><cites>FETCH-LOGICAL-c514t-d6e3bd7cc78b0c55087898608bbd8f156346adbeead605dbef814c13b0919feb3</cites><orcidid>0000-0003-2377-0908 ; 0000-0003-2332-8554 ; 0000-0002-3276-799X ; 0000-0003-1053-3671 ; 0000-0001-7627-628X ; 0000-0002-8455-5606 ; 0000-0002-4162-1511</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289612/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289612/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34336123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Teodoro, Anderson J.</contributor><contributor>Anderson J Teodoro</contributor><creatorcontrib>Zhou, Dan-Dan</creatorcontrib><creatorcontrib>Luo, Min</creatorcontrib><creatorcontrib>Huang, Si-Yu</creatorcontrib><creatorcontrib>Saimaiti, Adila</creatorcontrib><creatorcontrib>Shang, Ao</creatorcontrib><creatorcontrib>Gan, Ren-You</creatorcontrib><creatorcontrib>Li, Hua-Bin</creatorcontrib><title>Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>The aging of population has become an issue of great concern because of its rapid increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be found in many foods, such as grapes, red wine, peanuts, and blueberries. Many studies reported that resveratrol possessed various bioactivities, such as antioxidant, anti-inflammatory, cardiovascular protection, anticancer, antidiabetes mellitus, antiobesity, neuroprotection, and antiaging effects. The antiaging mechanisms of resveratrol were mainly ameliorating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol could be an effective and safe compound for the prevention and treatment of aging and age-related diseases. 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| subjects | Age Aging Aging - drug effects Animal cognition Animals Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis Autophagy Cell culture Cognitive ability Diet Dopamine Humans Inflammation Insects Kinases Memory Microbiota Nematodes Neurodegeneration Neurogenesis Oral administration Oxidative stress Population Resveratrol - pharmacology Resveratrol - therapeutic use Review Sarcopenia Senescence Tumors |
| title | Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases |
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