Gut microbes impact stroke severity via the trimethylamine N-oxide pathway

Clinical studies have demonstrated associations between circulating levels of the gut-microbiota-derived metabolite trimethylamine-N-oxide (TMAO) and stroke incident risk. However, a causal role of gut microbes in stroke has not yet been demonstrated. Herein we show that gut microbes, through dietar...

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Veröffentlicht in:	Cell host & microbe 2021-07, Vol.29 (7), p.1199-1208.e5
Hauptverfasser:	Zhu, Weifei, Romano, Kymberleigh A., Li, Lin, Buffa, Jennifer A., Sangwan, Naseer, Prakash, Prem, Tittle, Aaron N., Li, Xinmin S., Fu, Xiaoming, Androjna, Charlie, DiDonato, Anthony J., Brinson, Kimberly, Trapp, Bruce D., Fischbach, Michael A., Rey, Federico E., Hajjar, Adeline M., DiDonato, Joseph A., Hazen, Stanley L.
Format:	Artikel
Sprache:	eng
Schlagworte:	cerebral vascular diseases Choline CutC fecal microbial transplantation gnotobiotic mice gut microbiota metabolism preclinical models of stroke TMAO trimethylamine-N-oxide Western diet
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