The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN

NfsA is a dimeric flavoprotein that catalyses the reduction in nitroaromatics and quinones by NADPH. This reduction is required for the activity of nitrofuran antibiotics. The crystal structure of free Escherichia coli NfsA and several homologues have been determined previously, but there is no stru...

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Veröffentlicht in:	Biochemical journal 2021-07, Vol.478 (13), p.2601-2617
Hauptverfasser:	Day, Martin A., Jarrom, David, Christofferson, Andrew J., Graziano, Antonio E., Anderson, J. L. Ross, Searle, Peter F., Hyde, Eva I., White, Scott A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Computational Biology Enzymology Structural Biology
Online-Zugang:	Volltext
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