RADX prevents genome instability by confining replication fork reversal to stalled forks

RAD51 facilitates replication fork reversal and protects reversed forks from nuclease degradation. Although potentially a useful replication stress response mechanism, unregulated fork reversal can cause genome instability. Here we show that RADX, a single-strand DNA binding protein that binds to an...

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Veröffentlicht in:	Molecular cell 2021-07, Vol.81 (14), p.3007-3017.e5
Hauptverfasser:	Krishnamoorthy, Archana, Jackson, Jessica, Mohamed, Taha, Adolph, Madison, Vindigni, Alessandro, Cortez, David
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA2 DNA damage DNA repair DNA replication electron microscopy genome instability telomere
Online-Zugang:	Volltext
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