Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer

Endometrial cancer (EC) is widely known as an aggressive malignancy. Due to the limited therapeutic options and poor prognosis of patients with advanced‑stage EC, there is a need to identify effective alternative treatments. Chrysin is a naturally active flavonoid (5,7‑dihydroxyflavone), which has b...

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Veröffentlicht in:	International journal of molecular medicine 2021-09, Vol.48 (3), p.1, Article 172
Hauptverfasser:	He, Yu, Shi, Yuchuan, Yang, Yang, Huang, Huanhuan, Feng, Yifan, Wang, Yunmeng, Zhan, Lei, Wei, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Antibodies Antineoplastic Agents - pharmacology Apoptosis Autophagy Autophagy - drug effects Biotechnology Cancer Care and treatment Cell Line, Tumor Endometrial cancer Endometrial Neoplasms - drug therapy Endometrial Neoplasms - metabolism Ethylenediaminetetraacetic acid Female Flavonoids - pharmacology Health aspects Humans Medical prognosis Penicillin Prognosis Proteins Proto-Oncogene Proteins c-akt - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Scientific equipment and supplies industry Signal Transduction - drug effects TOR Serine-Threonine Kinases - metabolism
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