Anticancer Activity and In Vitro to In Vivo Mechanistic Recapitulation of Novel Ruthenium-Based Metallodrugs in the Zebrafish Model

Abstract Ruthenium is popular as a metal core for chemotherapeutics, due to versatile molecular coordination. Because new metallodrugs are synthesized at high rates, our studies included assays in zebrafish to expedite the initial evaluation as anticancer agents. Here we evaluated novel metallodrugs...

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Veröffentlicht in:	Toxicological sciences 2021-07, Vol.182 (1), p.29-43
Hauptverfasser:	Karas, Brittany F, Hotz, Jordan M, Gural, Brian M, Terez, Kristin R, DiBona, Victoria L, Côrte-Real, Leonor, Valente, Andreia, Buckley, Brian T, Cooper, Keith R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - toxicity Cell Proliferation Cisplatin - toxicity Clinical and Translational Toxicology Ruthenium - toxicity Zebrafish
Online-Zugang:	Volltext
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