Clinical significance of YAP1 and TAZ in esophageal squamous cell carcinoma
Esophageal cancer is the eighth most frequent and sixth most fatal cancer worldwide. This study aimed to investigate the clinical characteristics and prognostic significance of yes related protein 1 (YAP1) and transcriptional co-activator with PDZ binding motif (TAZ) in patients with esophageal squa...
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| Veröffentlicht in: | Medicine (Baltimore) 2021-07, Vol.100 (28), p.e26597-e26597 |
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| creator | Liu, Li Lu, Ziyang Hu, Xiayun Su, Tianyuan Su, Liping Pu, Hongwei |
| description | Esophageal cancer is the eighth most frequent and sixth most fatal cancer worldwide. This study aimed to investigate the clinical characteristics and prognostic significance of yes related protein 1 (YAP1) and transcriptional co-activator with PDZ binding motif (TAZ) in patients with esophageal squamous cell carcinoma (ESCC).
A total of 306 ESCC pathological specimens and adjacent tissues (as control; tissues from the esophageal mucosa >5 cm from the edge of the tumor) were collected between January, 2008 and December, 2018. Immunohistochemical staining was used to assess the expression of YAP1 and TAZ proteins in the ESCC and adjacent tissues, and their relationship with clinicopathological parameters was evaluated using SPSS 21.0 software.
YAP1 and TAZ proteins were highly expressed in ESCC, and their expression was closely related to TNM stage and lymph node metastasis. Expression of YAP1 was associated with tumor size (P = .029), differentiation (P = .000), depth of invasion (P = .001), and TNM stage (P = .000). Expression of TAZ was associated with tumor size (P = .034), differentiation (P = .000), depth of invasion (P = .029), lymph node metastasis (P = .006), and ethnicity (P |
| doi_str_mv | 10.1097/MD.0000000000026597 |
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A total of 306 ESCC pathological specimens and adjacent tissues (as control; tissues from the esophageal mucosa >5 cm from the edge of the tumor) were collected between January, 2008 and December, 2018. Immunohistochemical staining was used to assess the expression of YAP1 and TAZ proteins in the ESCC and adjacent tissues, and their relationship with clinicopathological parameters was evaluated using SPSS 21.0 software.
YAP1 and TAZ proteins were highly expressed in ESCC, and their expression was closely related to TNM stage and lymph node metastasis. Expression of YAP1 was associated with tumor size (P = .029), differentiation (P = .000), depth of invasion (P = .001), and TNM stage (P = .000). Expression of TAZ was associated with tumor size (P = .034), differentiation (P = .000), depth of invasion (P = .029), lymph node metastasis (P = .006), and ethnicity (P < .001). The expression of YAP1 protein was positively correlated with the expression of TAZ protein (r = 0.257, P < .05). YAP1 and TAZ expression (P = .039 and .000, respectively), tumor size (P = .041), and lymph node metastasis (P = .001) significantly affected the overall survival of patients with ESCC, and represent independent factors for overall survival.
YAP1 and TAZ proteins are highly expressed in ESCC, and closely related to the clinical and pathological parameters such as the diameter of the tumor, degree of differentiation, and depth of invasion, indicating that YAP1 and TAZ may be involved in the development of ESCC. YAP1 and TAZ may be used as prognostic markers in ESCC.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000026597</identifier><identifier>PMID: 34260541</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Adaptor Proteins, Signal Transducing - biosynthesis ; Aged ; Biomarkers, Tumor ; Clinical Trial/Experimental Study ; Esophageal Neoplasms - ethnology ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - pathology ; Esophageal Squamous Cell Carcinoma - ethnology ; Esophageal Squamous Cell Carcinoma - genetics ; Esophageal Squamous Cell Carcinoma - pathology ; Ethnicity ; Female ; Humans ; Intracellular Signaling Peptides and Proteins - biosynthesis ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; Survival Analysis ; Transcription Factors - biosynthesis ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; Tumor Burden ; YAP-Signaling Proteins</subject><ispartof>Medicine (Baltimore), 2021-07, Vol.100 (28), p.e26597-e26597</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4504-826bcebaf1f20a0c7c07af16e01cc574071bd1af5581f838cf4505d491ee2e6c3</citedby><cites>FETCH-LOGICAL-c4504-826bcebaf1f20a0c7c07af16e01cc574071bd1af5581f838cf4505d491ee2e6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284757/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284757/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34260541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Lu, Ziyang</creatorcontrib><creatorcontrib>Hu, Xiayun</creatorcontrib><creatorcontrib>Su, Tianyuan</creatorcontrib><creatorcontrib>Su, Liping</creatorcontrib><creatorcontrib>Pu, Hongwei</creatorcontrib><title>Clinical significance of YAP1 and TAZ in esophageal squamous cell carcinoma</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Esophageal cancer is the eighth most frequent and sixth most fatal cancer worldwide. This study aimed to investigate the clinical characteristics and prognostic significance of yes related protein 1 (YAP1) and transcriptional co-activator with PDZ binding motif (TAZ) in patients with esophageal squamous cell carcinoma (ESCC).
A total of 306 ESCC pathological specimens and adjacent tissues (as control; tissues from the esophageal mucosa >5 cm from the edge of the tumor) were collected between January, 2008 and December, 2018. Immunohistochemical staining was used to assess the expression of YAP1 and TAZ proteins in the ESCC and adjacent tissues, and their relationship with clinicopathological parameters was evaluated using SPSS 21.0 software.
YAP1 and TAZ proteins were highly expressed in ESCC, and their expression was closely related to TNM stage and lymph node metastasis. Expression of YAP1 was associated with tumor size (P = .029), differentiation (P = .000), depth of invasion (P = .001), and TNM stage (P = .000). Expression of TAZ was associated with tumor size (P = .034), differentiation (P = .000), depth of invasion (P = .029), lymph node metastasis (P = .006), and ethnicity (P < .001). The expression of YAP1 protein was positively correlated with the expression of TAZ protein (r = 0.257, P < .05). YAP1 and TAZ expression (P = .039 and .000, respectively), tumor size (P = .041), and lymph node metastasis (P = .001) significantly affected the overall survival of patients with ESCC, and represent independent factors for overall survival.
YAP1 and TAZ proteins are highly expressed in ESCC, and closely related to the clinical and pathological parameters such as the diameter of the tumor, degree of differentiation, and depth of invasion, indicating that YAP1 and TAZ may be involved in the development of ESCC. YAP1 and TAZ may be used as prognostic markers in ESCC.</description><subject>Adaptor Proteins, Signal Transducing - biosynthesis</subject><subject>Aged</subject><subject>Biomarkers, Tumor</subject><subject>Clinical Trial/Experimental Study</subject><subject>Esophageal Neoplasms - ethnology</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Squamous Cell Carcinoma - ethnology</subject><subject>Esophageal Squamous Cell Carcinoma - genetics</subject><subject>Esophageal Squamous Cell Carcinoma - pathology</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Humans</subject><subject>Intracellular Signaling Peptides and Proteins - biosynthesis</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Survival Analysis</subject><subject>Transcription Factors - biosynthesis</subject><subject>Transcriptional Coactivator with PDZ-Binding Motif Proteins</subject><subject>Tumor Burden</subject><subject>YAP-Signaling Proteins</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtvEzEUhS1ERUPhFyAhL9lMufb4MbNBilJeaitYlAVsLMe5TgwzdmpnqPj3OKQtBW_8-s6x77mEvGBwyqDXry_PTuHv4Er2-hGZMdmqRvZKPCazeiob3WtxTJ6W8h2AtZqLJ-S4FVyBFGxGzhdDiMHZgZawjsHXZXRIk6df558ZtXFFr-bfaIgUS9pu7Br36PVkxzQV6nAYqLPZhZhG-4wceTsUfH47n5Av795eLT40F5_ef1zMLxonJIim42rpcGk98xwsOO1A141CYM5JLUCz5YpZL2XHfNd2zleZXImeIXJUrj0hbw6-22k54sph3GU7mG0Oo82_TLLB_HsTw8as00_T8U5oqavBq1uDnK4nLDszhrKvxUasZRkuJQcFou0q2h5Ql1MpGf39MwzMvg3m8sz834aqevnwh_eau9wrIA7ATRp2mMuPYbrBbDY13d3mj5_UPW84cFbjUNDsrUX7GzWFkpE</recordid><startdate>20210716</startdate><enddate>20210716</enddate><creator>Liu, Li</creator><creator>Lu, Ziyang</creator><creator>Hu, Xiayun</creator><creator>Su, Tianyuan</creator><creator>Su, Liping</creator><creator>Pu, Hongwei</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210716</creationdate><title>Clinical significance of YAP1 and TAZ in esophageal squamous cell carcinoma</title><author>Liu, Li ; Lu, Ziyang ; Hu, Xiayun ; Su, Tianyuan ; Su, Liping ; Pu, Hongwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4504-826bcebaf1f20a0c7c07af16e01cc574071bd1af5581f838cf4505d491ee2e6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adaptor Proteins, Signal Transducing - biosynthesis</topic><topic>Aged</topic><topic>Biomarkers, Tumor</topic><topic>Clinical Trial/Experimental Study</topic><topic>Esophageal Neoplasms - ethnology</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Squamous Cell Carcinoma - ethnology</topic><topic>Esophageal Squamous Cell Carcinoma - genetics</topic><topic>Esophageal Squamous Cell Carcinoma - pathology</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Humans</topic><topic>Intracellular Signaling Peptides and Proteins - biosynthesis</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Survival Analysis</topic><topic>Transcription Factors - biosynthesis</topic><topic>Transcriptional Coactivator with PDZ-Binding Motif Proteins</topic><topic>Tumor Burden</topic><topic>YAP-Signaling Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Lu, Ziyang</creatorcontrib><creatorcontrib>Hu, Xiayun</creatorcontrib><creatorcontrib>Su, Tianyuan</creatorcontrib><creatorcontrib>Su, Liping</creatorcontrib><creatorcontrib>Pu, Hongwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Li</au><au>Lu, Ziyang</au><au>Hu, Xiayun</au><au>Su, Tianyuan</au><au>Su, Liping</au><au>Pu, Hongwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of YAP1 and TAZ in esophageal squamous cell carcinoma</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-07-16</date><risdate>2021</risdate><volume>100</volume><issue>28</issue><spage>e26597</spage><epage>e26597</epage><pages>e26597-e26597</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Esophageal cancer is the eighth most frequent and sixth most fatal cancer worldwide. This study aimed to investigate the clinical characteristics and prognostic significance of yes related protein 1 (YAP1) and transcriptional co-activator with PDZ binding motif (TAZ) in patients with esophageal squamous cell carcinoma (ESCC).
A total of 306 ESCC pathological specimens and adjacent tissues (as control; tissues from the esophageal mucosa >5 cm from the edge of the tumor) were collected between January, 2008 and December, 2018. Immunohistochemical staining was used to assess the expression of YAP1 and TAZ proteins in the ESCC and adjacent tissues, and their relationship with clinicopathological parameters was evaluated using SPSS 21.0 software.
YAP1 and TAZ proteins were highly expressed in ESCC, and their expression was closely related to TNM stage and lymph node metastasis. Expression of YAP1 was associated with tumor size (P = .029), differentiation (P = .000), depth of invasion (P = .001), and TNM stage (P = .000). Expression of TAZ was associated with tumor size (P = .034), differentiation (P = .000), depth of invasion (P = .029), lymph node metastasis (P = .006), and ethnicity (P < .001). The expression of YAP1 protein was positively correlated with the expression of TAZ protein (r = 0.257, P < .05). YAP1 and TAZ expression (P = .039 and .000, respectively), tumor size (P = .041), and lymph node metastasis (P = .001) significantly affected the overall survival of patients with ESCC, and represent independent factors for overall survival.
YAP1 and TAZ proteins are highly expressed in ESCC, and closely related to the clinical and pathological parameters such as the diameter of the tumor, degree of differentiation, and depth of invasion, indicating that YAP1 and TAZ may be involved in the development of ESCC. YAP1 and TAZ may be used as prognostic markers in ESCC.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>34260541</pmid><doi>10.1097/MD.0000000000026597</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adaptor Proteins, Signal Transducing - biosynthesis Aged Biomarkers, Tumor Clinical Trial/Experimental Study Esophageal Neoplasms - ethnology Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma - ethnology Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - pathology Ethnicity Female Humans Intracellular Signaling Peptides and Proteins - biosynthesis Kaplan-Meier Estimate Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Prognosis Survival Analysis Transcription Factors - biosynthesis Transcriptional Coactivator with PDZ-Binding Motif Proteins Tumor Burden YAP-Signaling Proteins |
| title | Clinical significance of YAP1 and TAZ in esophageal squamous cell carcinoma |
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