Megakaryocyte production is sustained by direct differentiation from erythromyeloid progenitors in the yolk sac until midgestation

The extra-embryonic yolk sac contains the first definitive multipotent hematopoietic cells, denominated erythromyeloid progenitors. They originate in situ prior to the emergence of hematopoietic stem cells and give rise to erythroid, monocytes, granulocytes, mast cells and macrophages, the latter in...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2021-07, Vol.54 (7), p.1433-1446.e5
Hauptverfasser:	Iturri, Lorea, Freyer, Laina, Biton, Anne, Dardenne, Pascal, Lallemand, Yvan, Gomez Perdiguero, Elisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Colonization Development Biology Differentiation Efficiency embryo Embryos Endothelium Erythrocytes erythropoiesis fate mapping fetal liver Fetuses Flow cytometry Gene expression hematopoiesis Hematopoietic stem cells Heterogeneity Labeling Leukocytes (granulocytic) Life Sciences Liver Macrophages Mast cells Megakaryocytes megakaryopoiesis Monocytes Population Progenitor cells resident macrophages scRNAseq Stem cells Yolk Yolk sac
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