Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis

Background Accessing COVID-19 vaccines is a challenge despite successful clinical trials. This burdens the COVID-19 treatment gap, thereby requiring accelerated discovery of anti-SARS-CoV-2 agents. This study explored the potential of anti-HIV reverse transcriptase (RT) phytochemicals as inhibitors...

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Veröffentlicht in:	Journal of Genetic Engineering and Biotechnology 2021-07, Vol.19 (1), p.104-17, Article 104
Hauptverfasser:	de Leon, Von Novi O., Manzano, Joe Anthony H., Pilapil, Delfin Yñigo H., Fernandez, Rey Arturo T., Ching, James Kyle Anthony R., Quimque, Mark Tristan J., Agbay, Jay Carl M., Notarte, Kin Israel R., Macabeo, Allan Patrick G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptivity Active sites ADMET Biomedical Engineering and Bioengineering Clinical trials Coronaviruses COVID-19 COVID-19 vaccines DNA polymerases Drug development Engineering Enzymes Force and energy Health aspects HIV HIV (Viruses) Human immunodeficiency virus Hydrogen Ligands Molecular docking Molecular dynamics Natural products Non-structural proteins Pathogenesis Pharmacokinetics Phytochemicals Polyphenolics Post-translation Proteins Respiratory diseases RNA-directed DNA polymerase SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Simulation Structural proteins Terpenoids Toxicity Vaccines Viruses
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