N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

N6-Methyladenosine (m6A) on mRNAs mediates different biological processes and its dysregulation contributes to tumorigenesis. How m6A dictates its diverse molecular and cellular effects in leukemias remains unknown. We found that YTHDC1 is the essential m6A reader in myeloid leukemia from a genome-w...

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Veröffentlicht in:	Cancer cell 2021-07, Vol.39 (7), p.958-972.e8
Hauptverfasser:	Cheng, Yuanming, Xie, Wei, Pickering, Brian F., Chu, Karen L., Savino, Angela M., Yang, Xuejing, Luo, Hanzhi, Nguyen, Diu TT, Mo, Shanlan, Barin, Ersilia, Velleca, Anthony, Rohwetter, Thomas M., Patel, Dinshaw J., Jaffrey, Samie R., Kharas, Michael G.
Format:	Artikel
Sprache:	eng
Schlagworte:	differentiation myeloid leukemia phase separation RNA methylation RNA-binding proteins
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