Respiratory effects of low and high doses of fentanyl in control and β-arrestin 2-deficient mice

We have investigated the potential acute desensitizing role of the β arrestin 2 (β-arr2) pathway on the ventilatory depression produced by levels of fentanyl ranging from analgesic to life-threatening (0.1 to 60 mg/kg ip) in control and β-arr2-deficient nonsedated mice. Fentanyl at doses of 0.1, 0.5...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurophysiology 2021-04, Vol.125 (4), p.1396-1407
Hauptverfasser:	Haouzi, Philippe, McCann, Marissa, Tubbs, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Analgesics, Opioid - pharmacology Animals Apnea - chemically induced Behavior, Animal - drug effects beta-Arrestin 2 - deficiency beta-Arrestin 2 - metabolism Disease Models, Animal Female Fentanyl - administration & dosage Fentanyl - adverse effects Fentanyl - pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Opiate Overdose - metabolism Respiration - drug effects Signal Transduction - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!