Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients

The ability to predict invasive fungal infections (IFI) in patients with hematological malignancies is fundamental for successful therapy. Although gut dysbiosis is known to occur in hematological patients, whether airway dysbiosis also contributes to the risk of IFI has not been investigated. Nasal...

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Veröffentlicht in:	Infection and immunity 2021-07, Vol.89 (8), p.e0010521-e0010521
Hauptverfasser:	Costantini, Claudio, Nunzi, Emilia, Spolzino, Angelica, Palmieri, Melissa, Renga, Giorgia, Zelante, Teresa, Englmaier, Lukas, Coufalikova, Katerina, Spáčil, Zdeněk, Borghi, Monica, Bellet, Marina M, Acerbi, Enzo, Puccetti, Matteo, Giovagnoli, Stefano, Spaccapelo, Roberta, Talesa, Vincenzo N, Lomurno, Giuseppe, Merli, Francesco, Facchini, Luca, Spadea, Antonio, Melillo, Lorella, Codeluppi, Katia, Marchesi, Francesco, Marchesini, Gessica, Valente, Daniela, Dragonetti, Giulia, Nadali, Gianpaolo, Pagano, Livio, Aversa, Franco, Romani, Luigina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Disease Models, Animal Hematologic Diseases - complications Hematologic Neoplasms - complications Host-Associated Microbial Communities Humans Metagenome Metagenomics - methods Mice Microbiota Mycoses - diagnosis Mycoses - drug therapy Mycoses - etiology Pharynx - microbiology Pneumonia - diagnosis Pneumonia - drug therapy Pneumonia - etiology Risk Assessment Risk Factors Spotlight
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