Synergic fabrication of pembrolizumab loaded doxorubicin incorporating microbubbles delivery for ultrasound contrast agents mediated anti-proliferation and apoptosis

This study evaluated pembrolizumab-conjugated, doxorubicin (DOX)-loaded microbubbles (PDMs) in combination with ultrasound (US) as molecular imaging agents for early diagnosis of B cell lymphomas, and as a targeted drug delivery system. Pembrolizumab, a monoclonal CD20 antibody, was attached to the...

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Veröffentlicht in:	Drug delivery 2021-01, Vol.28 (1), p.1466-1477
Hauptverfasser:	Liu, Huilin, Li, Xing, Chen, Zihe, Bai, Lianjie, Wang, Ying, Lv, Weiyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - pharmacology Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects B cell lymphoma Cell Line, Tumor Cell Survival Chemistry, Pharmaceutical Contrast Media - administration & dosage Contrast Media - pharmacology Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug Carriers Drug Combinations Drug delivery systems Drug Liberation Humans Immunotherapy Lymphoma Lymphoma, B-Cell - diagnosis Mice microbubble Microbubbles Monoclonal antibodies Pembrolizumab Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Targeted cancer therapy theranostics Ultrasonic imaging ultrasound Xenograft Model Antitumor Assays
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