Immune System Effects on Breast Cancer
Breast cancer is one of the most common cancers in women, with the ability to metastasize to secondary organs, which is the main cause of cancer-related deaths. Understanding how breast tumors progress is essential for developing better treatment strategies against breast cancer. Until recently, it...
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| Veröffentlicht in: | Cellular and molecular bioengineering 2021-08, Vol.14 (4), p.279-292 |
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| creator | Amens, Jensen N. Bahçecioglu, Gökhan Zorlutuna, Pinar |
| description | Breast cancer is one of the most common cancers in women, with the ability to metastasize to secondary organs, which is the main cause of cancer-related deaths. Understanding how breast tumors progress is essential for developing better treatment strategies against breast cancer. Until recently, it has been considered that breast cancer elicits a small immune response. However, it is now clear that breast tumor progression is either prevented by the action of antitumor immunity or exacerbated by proinflammatory cytokines released mainly by the immune cells. In this comprehensive review we first explain antitumor immunity, then continue with how the tumor suppresses and evades the immune response, and next, outline the role of inflammation in breast tumor initiation and progression. We finally review the current immunotherapeutic and immunoengineering strategies against breast cancer as a promising emerging approach for the discovery and design of immune system-based strategies for breast cancer treatment. |
| doi_str_mv | 10.1007/s12195-021-00679-8 |
| format | Article |
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Mol. Bioeng</addtitle><addtitle>Cell Mol Bioeng</addtitle><description>Breast cancer is one of the most common cancers in women, with the ability to metastasize to secondary organs, which is the main cause of cancer-related deaths. Understanding how breast tumors progress is essential for developing better treatment strategies against breast cancer. Until recently, it has been considered that breast cancer elicits a small immune response. However, it is now clear that breast tumor progression is either prevented by the action of antitumor immunity or exacerbated by proinflammatory cytokines released mainly by the immune cells. In this comprehensive review we first explain antitumor immunity, then continue with how the tumor suppresses and evades the immune response, and next, outline the role of inflammation in breast tumor initiation and progression. 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| source | Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Biological and Medical Physics Biomaterials Biomedical Engineering and Bioengineering Biomedical Engineering/Biotechnology Biophysics Breast cancer Cell Biology Cytokines Engineering Immune response Immune system Immunity Inflammation Organs Review Tumors |
| title | Immune System Effects on Breast Cancer |
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