Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu2/mGlu4 receptor heterodimers

Synapse-specific partnershipNeurotransmission between the thalamus and medial prefrontal cortex (mPFC) in the brain regulates working memory and goal-directed and social dominance behaviors. Increased activity at synapses between the thalamus and the mPFC is implicated in some symptoms of schizophre...

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Veröffentlicht in:	Science signaling 2021-04, Vol.14 (677)
Hauptverfasser:	Xiang, Zixiu, Lv, Xiaohui, Lin, Xin, O'Brien, Daniel E, Altman, Molly K, Lindsley, Craig W, Javitch, Jonathan A, Niswender, Colleen M, Conn, P Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Amygdala Brain Brain slice preparation Cell lines Central nervous system Cognitive ability Disorders Electrophysiology Glutamatergic transmission Glutamic acid receptors Glutamic acid receptors (metabotropic) Hippocampus Mental disorders Neurotransmission Prefrontal cortex Receptors Schizophrenia Short term memory Signs and symptoms Social behavior Synapses Synaptic transmission Thalamus
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