Therapeutic Plasma Exchange in Vaccine-Induced Immune Thrombotic Thrombocytopenia

Three patients with severe manifestations of VITT after Covid-19 vaccination had a poor response to initial therapy with anticoagulants and intravenous immune globulin. Their conditions improved after therapeutic plasma exchange was initiated, and they were able to leave the hospital.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2021-08, Vol.385 (9), p.857-859
Hauptverfasser:	Patriquin, Christopher J, Laroche, Vincent, Selby, Rita, Pendergrast, Jacob, Barth, David, Côté, Benoit, Gagnon, Nathalie, Roberge, Guillaume, Carrier, Marc, Castellucci, Lana A, Scarvelis, Dimitrios, Mack, Johnathan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - therapeutic use Anticoagulation Blood platelets Cardiology ChAdOx1 nCoV-19 Coagulation Combined Modality Therapy Coronavirus Coronaviruses Correspondence COVID-19 COVID-19 Vaccines - adverse effects Critical Care Enzymes Female Fibrin Fibrinogen Degradation Products - analysis Globulins Glucocorticoids - therapeutic use Hematology Humans Immunization Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Infectious Disease Intravenous administration Methylprednisolone - therapeutic use Middle Aged Oncology Patients Plasma Plasma Exchange Platelet Count Prednisone - therapeutic use Pulmonary Purpura, Thrombocytopenic, Idiopathic - etiology Purpura, Thrombocytopenic, Idiopathic - therapy Thrombocytopenia Thromboembolism Thrombosis Thrombosis - etiology Thrombosis - therapy Vaccination Vaccines Veins & arteries
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Beschreibung
Zusammenfassung:	Three patients with severe manifestations of VITT after Covid-19 vaccination had a poor response to initial therapy with anticoagulants and intravenous immune globulin. Their conditions improved after therapeutic plasma exchange was initiated, and they were able to leave the hospital.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMc2109465