Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum
Three new diterpene alkaloids, tangutidines A–C ( 1 – 3 ), and four known alkaloids ( 4 – 7 ) were isolated from the whole plant of Aconitum tanguticum , from which amphoteric diterpene alkaloids ( 1 – 3 ) were obtained for the first time. The structures of 1 – 3 were elucidated by detailed interpre...
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| Veröffentlicht in: | Natural Products and Bioprospecting 2021-08, Vol.11 (4), p.459-464 |
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| container_title | Natural Products and Bioprospecting |
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| creator | Li, Hao-Yi Yan, Bing-Chao Wei, Li-Xin Sun, Han-Dong Puno, Pema-Tenzin |
| description | Three new diterpene alkaloids, tangutidines A–C (
1
–
3
), and four known alkaloids (
4
–
7
) were isolated from the whole plant of
Aconitum tanguticum
, from which amphoteric diterpene alkaloids (
1
–
3
) were obtained for the first time. The structures of
1
–
3
were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities.
Graphic Abstract |
| doi_str_mv | 10.1007/s13659-021-00310-3 |
| format | Article |
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1
–
3
), and four known alkaloids (
4
–
7
) were isolated from the whole plant of
Aconitum tanguticum
, from which amphoteric diterpene alkaloids (
1
–
3
) were obtained for the first time. The structures of
1
–
3
were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities.
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1
–
3
), and four known alkaloids (
4
–
7
) were isolated from the whole plant of
Aconitum tanguticum
, from which amphoteric diterpene alkaloids (
1
–
3
) were obtained for the first time. The structures of
1
–
3
were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities.
Graphic Abstract</description><subject>Aconitum</subject><subject>Alkaloids</subject><subject>Amphoterics</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Cytotoxicity</subject><subject>Diterpenes</subject><subject>Food Science</subject><subject>Laboratories</subject><subject>Life Sciences</subject><subject>Medicinal Chemistry</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pharmacology/Toxicology</subject><subject>Plant Biochemistry</subject><subject>Plant Sciences</subject><subject>Short Communication</subject><issn>2192-2195</issn><issn>2192-2209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UctuFDEQtBCIREt-gAMaiQsHJvgxHtsXpNHylCIhpOVseT3tXYcZe7FnInHjH_jDfEm8TBIeB-xDW91V1d0uhJ4SfE4wFq8yYS1XNaakxpgRXLMH6JQSRWtKsXp49yaKn6CznC9xOS3mLW0eoxPGlJCK4VP0eWPCbp587wPkqrv-8XP9strsE0DVjYd9nCB5W73xJR4glOTw1QzR97lyKY5VZ2Pw0zxW0yJj5_EJeuTMkOHsNq7Ql3dvN-sP9cWn9x_X3UVteSOmugWCJe97QRoOcqssIVZtJSVuq1zDiQTLnCoAKbBifdMwQ1QhCN466bhgK_R60T3M2xF6C2FKZtCH5EeTvutovP67Evxe7-KVllRwWTRX6MWtQIrfZsiTHn22MAwmQJyzppy2hAnKjr2e_wO9jHMKZb2C4rgpkkIW1PmC2pkBtA8ulr623B5GXz4KnC_5rm0laxosj7J0IdgUc07g7qcnWB9d1ovLurisf7msWSE9-3Pve8qdpwXAFkAupbCD9HvY_8jeAGZFsoM</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Li, Hao-Yi</creator><creator>Yan, Bing-Chao</creator><creator>Wei, Li-Xin</creator><creator>Sun, Han-Dong</creator><creator>Puno, Pema-Tenzin</creator><general>Springer Singapore</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>LK8</scope><scope>M7P</scope><scope>M7S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5212-3000</orcidid></search><sort><creationdate>20210801</creationdate><title>Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum</title><author>Li, Hao-Yi ; Yan, Bing-Chao ; Wei, Li-Xin ; Sun, Han-Dong ; Puno, Pema-Tenzin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-6e1085dd7145e8b9c11c9b821fb9f4518ec3f95dd87093d443a1985d756f8f573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aconitum</topic><topic>Alkaloids</topic><topic>Amphoterics</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Cytotoxicity</topic><topic>Diterpenes</topic><topic>Food Science</topic><topic>Laboratories</topic><topic>Life Sciences</topic><topic>Medicinal Chemistry</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pharmacology/Toxicology</topic><topic>Plant Biochemistry</topic><topic>Plant Sciences</topic><topic>Short Communication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Hao-Yi</creatorcontrib><creatorcontrib>Yan, Bing-Chao</creatorcontrib><creatorcontrib>Wei, Li-Xin</creatorcontrib><creatorcontrib>Sun, Han-Dong</creatorcontrib><creatorcontrib>Puno, Pema-Tenzin</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Natural Products and Bioprospecting</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Hao-Yi</au><au>Yan, Bing-Chao</au><au>Wei, Li-Xin</au><au>Sun, Han-Dong</au><au>Puno, Pema-Tenzin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum</atitle><jtitle>Natural Products and Bioprospecting</jtitle><stitle>Nat. Prod. Bioprospect</stitle><addtitle>Nat Prod Bioprospect</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>11</volume><issue>4</issue><spage>459</spage><epage>464</epage><pages>459-464</pages><issn>2192-2195</issn><eissn>2192-2209</eissn><abstract>Three new diterpene alkaloids, tangutidines A–C (
1
–
3
), and four known alkaloids (
4
–
7
) were isolated from the whole plant of
Aconitum tanguticum
, from which amphoteric diterpene alkaloids (
1
–
3
) were obtained for the first time. The structures of
1
–
3
were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities.
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central; Springer Nature OA/Free Journals |
| subjects | Aconitum Alkaloids Amphoterics Biomedical and Life Sciences Bioorganic Chemistry Cytotoxicity Diterpenes Food Science Laboratories Life Sciences Medicinal Chemistry NMR Nuclear magnetic resonance Pharmacology/Toxicology Plant Biochemistry Plant Sciences Short Communication |
| title | Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum |
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