Identification and Validation of Potential Biomarkers and Pathways for Idiopathic Pulmonary Fibrosis by Comprehensive Bioinformatics Analysis

Objective. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible, high-mortality lung disease, but its pathogenesis is still unclear. Our purpose was to explore potential genes and molecular mechanisms underlying IPF. Methods. IPF-related data were obtained from the GSE99621 da...

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Veröffentlicht in:	BioMed research international 2021, Vol.2021 (1), p.5545312-5545312
Hauptverfasser:	Qian, Weibin, Cai, Xinrui, Qian, Qiuhai, Zhang, Xinying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Analysis Angiogenesis Bioinformatics Biological activity Biological markers Biomarkers Biomarkers - metabolism Care and treatment Cell adhesion Cell adhesion & migration Cell culture Cell Line Chemokines Chemokines - metabolism Chemotaxis - genetics Computational Biology Datasets Diagnosis Disease Down-Regulation - genetics Extracellular matrix Fibroblasts Fibrosis Gene expression Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Genes Genetic aspects Genomics Humans Identification and classification Idiopathic Pulmonary Fibrosis - genetics Idiopathic Pulmonary Fibrosis - immunology Idiopathic Pulmonary Fibrosis - metabolism Inflammation Inflammation - genetics Inflammation - pathology Inflammatory response Ligands Lung diseases Medical prognosis Methods MicroRNA MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular modelling Oxidation Oxidation-reduction potential Pathogenesis Principal components analysis Protein arrays Protein interaction Protein Interaction Maps - genetics Protein-protein interactions Proteins Pulmonary fibrosis R&D Research & development Ribonucleic acid Risk factors RNA RNA sequencing Signal transduction Signal Transduction - genetics Statistical methods Up-Regulation - genetics Western immunoblotting
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