Antimicrobial use in hospitalized patients: a multicentre point prevalence survey across seven hospitals in Ghana

Antimicrobial use in hospitalized patients: a multicentre point prevalence survey across seven hospitals in Ghana

Background Antimicrobial resistance (AMR) is a public health crisis of global proportions. Data is required to understand the local drivers of antimicrobial resistance and support decision-making processes including implementation of appropriate antimicrobial stewardship strategies. Objectives To me...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:JAC-antimicrobial resistance 2021-09, Vol.3 (3), p.dlab087-dlab087
Hauptverfasser: Labi, Appiah-Korang, Obeng-Nkrumah, Noah, Dayie, Nicholas T K D, Egyir, Beverly, Sampane-Donkor, Eric, Newman, Mercy Jemima, Opintan, Japheth Awuletey
Format: Artikel
Sprache:eng
Schlagworte:
Original
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page dlab087
container_issue 3
container_start_page dlab087
container_title JAC-antimicrobial resistance
container_volume 3
creator Labi, Appiah-Korang
Obeng-Nkrumah, Noah
Dayie, Nicholas T K D
Egyir, Beverly
Sampane-Donkor, Eric
Newman, Mercy Jemima
Opintan, Japheth Awuletey
description Background Antimicrobial resistance (AMR) is a public health crisis of global proportions. Data is required to understand the local drivers of antimicrobial resistance and support decision-making processes including implementation of appropriate antimicrobial stewardship strategies. Objectives To measure antimicrobial usage in hospitals in Ghana. Methods Using the Global Point Prevalence instruments and processes, we conducted point prevalence surveys across AMR surveillance sentinel hospitals in Ghana, between September and December 2019. Hospital records of all inpatients on admission at 0800 hours on a specific day were reviewed for antimicrobial use at the time of the survey. Data on antibiotic use, including indication for use and quality of prescribing were recorded. Results Overall prevalence of antibiotic use across the sentinel sites was 54.9% (n = 1591/2897), ranging between 48.4% (n = 266/550) and 67.2% (n = 82/122). The highest prevalence of antibiotic use 89.3% (n = 25/28) was observed in adult ICUs. The average number of antibiotics prescribed per patient was 1.7 (n = 1562/2620), with the majority (66%, n = 728/2620) administered via the parenteral route. The five most-commonly used antibiotics were metronidazole (20.6%, n = 541/2620), cefuroxime (12.9%, n = 338/2620), ceftriaxone (11.8%, n = 310/2620), amoxicillin/clavulanic acid (8.8%, n = 231/2620) and ciprofloxacin (7.8%, n = 204/2620). The majority (52.2%; n = 1367/2620) of antibiotics were prescribed to treat an infection, whilst surgical prophylaxis accounted for 26.1% (n = 684/2620). Conclusions We observed a high use of antibiotics including metronidazole and cephalosporins at the participating hospitals. Most antibiotics were empirically prescribed, with low use of microbiological cultures. High usage of third-generation cephalosporins especially for community-acquired infections offers an opportunity for antibiotic stewardship interventions.
doi_str_mv 10.1093/jacamr/dlab087
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8275021</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jacamr/dlab087</oup_id><sourcerecordid>2552057022</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-f58e8c65c4ebf5350115283a9e2a036c74227472c70440c472b01da4cf7ae6c33</originalsourceid><addsrcrecordid>eNqFkU1LA0EMhgdRbFGvHmWOemidz93Vg1BEq1DwouchO83akf3qzG5Bf71TW7WePCUhb54kvISccjbm7EpevoGFyl_OS8hZlu6RoUikGPFMyP2dfEBOQnhjjAnNUpWKQzKQKnZ5kgzJclJ3rnLWN7mDkvYBqavpogmt66B0HzinLXQO6y5cU6BVX3bOxsojbRtXd7T1uIISa4s09H6F7xQiLAQacIW_pLDGThdQwzE5KGKNJ9t4RF7u755vH0azp-nj7WQ2skqoblToDDObaKswL7TUjHMtMglXKIDJxKZKiPU3NmVKMRuznPE5KFukgImV8ojcbLhtn1c4_zoaStN6V4F_Nw0487dTu4V5bVYmE6lmgkfA-Rbgm2WPoTOVCxbLEmps-mCE1oLplAkRpeON9Ot1j8XPGs7M2iqzscpsrYoDZ7vH_ci_jYmCi42g6dv_YJ8L2qKm</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2552057022</pqid></control><display><type>article</type><title>Antimicrobial use in hospitalized patients: a multicentre point prevalence survey across seven hospitals in Ghana</title><source>DOAJ Directory of Open Access Journals</source><source>Oxford Journals Open Access Collection</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Labi, Appiah-Korang ; Obeng-Nkrumah, Noah ; Dayie, Nicholas T K D ; Egyir, Beverly ; Sampane-Donkor, Eric ; Newman, Mercy Jemima ; Opintan, Japheth Awuletey</creator><creatorcontrib>Labi, Appiah-Korang ; Obeng-Nkrumah, Noah ; Dayie, Nicholas T K D ; Egyir, Beverly ; Sampane-Donkor, Eric ; Newman, Mercy Jemima ; Opintan, Japheth Awuletey</creatorcontrib><description>Background Antimicrobial resistance (AMR) is a public health crisis of global proportions. Data is required to understand the local drivers of antimicrobial resistance and support decision-making processes including implementation of appropriate antimicrobial stewardship strategies. Objectives To measure antimicrobial usage in hospitals in Ghana. Methods Using the Global Point Prevalence instruments and processes, we conducted point prevalence surveys across AMR surveillance sentinel hospitals in Ghana, between September and December 2019. Hospital records of all inpatients on admission at 0800 hours on a specific day were reviewed for antimicrobial use at the time of the survey. Data on antibiotic use, including indication for use and quality of prescribing were recorded. Results Overall prevalence of antibiotic use across the sentinel sites was 54.9% (n = 1591/2897), ranging between 48.4% (n = 266/550) and 67.2% (n = 82/122). The highest prevalence of antibiotic use 89.3% (n = 25/28) was observed in adult ICUs. The average number of antibiotics prescribed per patient was 1.7 (n = 1562/2620), with the majority (66%, n = 728/2620) administered via the parenteral route. The five most-commonly used antibiotics were metronidazole (20.6%, n = 541/2620), cefuroxime (12.9%, n = 338/2620), ceftriaxone (11.8%, n = 310/2620), amoxicillin/clavulanic acid (8.8%, n = 231/2620) and ciprofloxacin (7.8%, n = 204/2620). The majority (52.2%; n = 1367/2620) of antibiotics were prescribed to treat an infection, whilst surgical prophylaxis accounted for 26.1% (n = 684/2620). Conclusions We observed a high use of antibiotics including metronidazole and cephalosporins at the participating hospitals. Most antibiotics were empirically prescribed, with low use of microbiological cultures. High usage of third-generation cephalosporins especially for community-acquired infections offers an opportunity for antibiotic stewardship interventions.</description><identifier>ISSN: 2632-1823</identifier><identifier>EISSN: 2632-1823</identifier><identifier>DOI: 10.1093/jacamr/dlab087</identifier><identifier>PMID: 34263166</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Original</subject><ispartof>JAC-antimicrobial resistance, 2021-09, Vol.3 (3), p.dlab087-dlab087</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-f58e8c65c4ebf5350115283a9e2a036c74227472c70440c472b01da4cf7ae6c33</citedby><cites>FETCH-LOGICAL-c424t-f58e8c65c4ebf5350115283a9e2a036c74227472c70440c472b01da4cf7ae6c33</cites><orcidid>0000-0002-1797-822X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275021/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275021/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1598,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34263166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Labi, Appiah-Korang</creatorcontrib><creatorcontrib>Obeng-Nkrumah, Noah</creatorcontrib><creatorcontrib>Dayie, Nicholas T K D</creatorcontrib><creatorcontrib>Egyir, Beverly</creatorcontrib><creatorcontrib>Sampane-Donkor, Eric</creatorcontrib><creatorcontrib>Newman, Mercy Jemima</creatorcontrib><creatorcontrib>Opintan, Japheth Awuletey</creatorcontrib><title>Antimicrobial use in hospitalized patients: a multicentre point prevalence survey across seven hospitals in Ghana</title><title>JAC-antimicrobial resistance</title><addtitle>JAC Antimicrob Resist</addtitle><description>Background Antimicrobial resistance (AMR) is a public health crisis of global proportions. Data is required to understand the local drivers of antimicrobial resistance and support decision-making processes including implementation of appropriate antimicrobial stewardship strategies. Objectives To measure antimicrobial usage in hospitals in Ghana. Methods Using the Global Point Prevalence instruments and processes, we conducted point prevalence surveys across AMR surveillance sentinel hospitals in Ghana, between September and December 2019. Hospital records of all inpatients on admission at 0800 hours on a specific day were reviewed for antimicrobial use at the time of the survey. Data on antibiotic use, including indication for use and quality of prescribing were recorded. Results Overall prevalence of antibiotic use across the sentinel sites was 54.9% (n = 1591/2897), ranging between 48.4% (n = 266/550) and 67.2% (n = 82/122). The highest prevalence of antibiotic use 89.3% (n = 25/28) was observed in adult ICUs. The average number of antibiotics prescribed per patient was 1.7 (n = 1562/2620), with the majority (66%, n = 728/2620) administered via the parenteral route. The five most-commonly used antibiotics were metronidazole (20.6%, n = 541/2620), cefuroxime (12.9%, n = 338/2620), ceftriaxone (11.8%, n = 310/2620), amoxicillin/clavulanic acid (8.8%, n = 231/2620) and ciprofloxacin (7.8%, n = 204/2620). The majority (52.2%; n = 1367/2620) of antibiotics were prescribed to treat an infection, whilst surgical prophylaxis accounted for 26.1% (n = 684/2620). Conclusions We observed a high use of antibiotics including metronidazole and cephalosporins at the participating hospitals. Most antibiotics were empirically prescribed, with low use of microbiological cultures. High usage of third-generation cephalosporins especially for community-acquired infections offers an opportunity for antibiotic stewardship interventions.</description><subject>Original</subject><issn>2632-1823</issn><issn>2632-1823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNqFkU1LA0EMhgdRbFGvHmWOemidz93Vg1BEq1DwouchO83akf3qzG5Bf71TW7WePCUhb54kvISccjbm7EpevoGFyl_OS8hZlu6RoUikGPFMyP2dfEBOQnhjjAnNUpWKQzKQKnZ5kgzJclJ3rnLWN7mDkvYBqavpogmt66B0HzinLXQO6y5cU6BVX3bOxsojbRtXd7T1uIISa4s09H6F7xQiLAQacIW_pLDGThdQwzE5KGKNJ9t4RF7u755vH0azp-nj7WQ2skqoblToDDObaKswL7TUjHMtMglXKIDJxKZKiPU3NmVKMRuznPE5KFukgImV8ojcbLhtn1c4_zoaStN6V4F_Nw0487dTu4V5bVYmE6lmgkfA-Rbgm2WPoTOVCxbLEmps-mCE1oLplAkRpeON9Ot1j8XPGs7M2iqzscpsrYoDZ7vH_ci_jYmCi42g6dv_YJ8L2qKm</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Labi, Appiah-Korang</creator><creator>Obeng-Nkrumah, Noah</creator><creator>Dayie, Nicholas T K D</creator><creator>Egyir, Beverly</creator><creator>Sampane-Donkor, Eric</creator><creator>Newman, Mercy Jemima</creator><creator>Opintan, Japheth Awuletey</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1797-822X</orcidid></search><sort><creationdate>20210901</creationdate><title>Antimicrobial use in hospitalized patients: a multicentre point prevalence survey across seven hospitals in Ghana</title><author>Labi, Appiah-Korang ; Obeng-Nkrumah, Noah ; Dayie, Nicholas T K D ; Egyir, Beverly ; Sampane-Donkor, Eric ; Newman, Mercy Jemima ; Opintan, Japheth Awuletey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-f58e8c65c4ebf5350115283a9e2a036c74227472c70440c472b01da4cf7ae6c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Labi, Appiah-Korang</creatorcontrib><creatorcontrib>Obeng-Nkrumah, Noah</creatorcontrib><creatorcontrib>Dayie, Nicholas T K D</creatorcontrib><creatorcontrib>Egyir, Beverly</creatorcontrib><creatorcontrib>Sampane-Donkor, Eric</creatorcontrib><creatorcontrib>Newman, Mercy Jemima</creatorcontrib><creatorcontrib>Opintan, Japheth Awuletey</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAC-antimicrobial resistance</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Labi, Appiah-Korang</au><au>Obeng-Nkrumah, Noah</au><au>Dayie, Nicholas T K D</au><au>Egyir, Beverly</au><au>Sampane-Donkor, Eric</au><au>Newman, Mercy Jemima</au><au>Opintan, Japheth Awuletey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial use in hospitalized patients: a multicentre point prevalence survey across seven hospitals in Ghana</atitle><jtitle>JAC-antimicrobial resistance</jtitle><addtitle>JAC Antimicrob Resist</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>3</volume><issue>3</issue><spage>dlab087</spage><epage>dlab087</epage><pages>dlab087-dlab087</pages><issn>2632-1823</issn><eissn>2632-1823</eissn><abstract>Background Antimicrobial resistance (AMR) is a public health crisis of global proportions. Data is required to understand the local drivers of antimicrobial resistance and support decision-making processes including implementation of appropriate antimicrobial stewardship strategies. Objectives To measure antimicrobial usage in hospitals in Ghana. Methods Using the Global Point Prevalence instruments and processes, we conducted point prevalence surveys across AMR surveillance sentinel hospitals in Ghana, between September and December 2019. Hospital records of all inpatients on admission at 0800 hours on a specific day were reviewed for antimicrobial use at the time of the survey. Data on antibiotic use, including indication for use and quality of prescribing were recorded. Results Overall prevalence of antibiotic use across the sentinel sites was 54.9% (n = 1591/2897), ranging between 48.4% (n = 266/550) and 67.2% (n = 82/122). The highest prevalence of antibiotic use 89.3% (n = 25/28) was observed in adult ICUs. The average number of antibiotics prescribed per patient was 1.7 (n = 1562/2620), with the majority (66%, n = 728/2620) administered via the parenteral route. The five most-commonly used antibiotics were metronidazole (20.6%, n = 541/2620), cefuroxime (12.9%, n = 338/2620), ceftriaxone (11.8%, n = 310/2620), amoxicillin/clavulanic acid (8.8%, n = 231/2620) and ciprofloxacin (7.8%, n = 204/2620). The majority (52.2%; n = 1367/2620) of antibiotics were prescribed to treat an infection, whilst surgical prophylaxis accounted for 26.1% (n = 684/2620). Conclusions We observed a high use of antibiotics including metronidazole and cephalosporins at the participating hospitals. Most antibiotics were empirically prescribed, with low use of microbiological cultures. High usage of third-generation cephalosporins especially for community-acquired infections offers an opportunity for antibiotic stewardship interventions.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>34263166</pmid><doi>10.1093/jacamr/dlab087</doi><orcidid>https://orcid.org/0000-0002-1797-822X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2632-1823
ispartof JAC-antimicrobial resistance, 2021-09, Vol.3 (3), p.dlab087-dlab087
issn 2632-1823
2632-1823
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8275021
source DOAJ Directory of Open Access Journals; Oxford Journals Open Access Collection; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Original
title Antimicrobial use in hospitalized patients: a multicentre point prevalence survey across seven hospitals in Ghana
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T14%3A04%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antimicrobial%20use%20in%20hospitalized%20patients:%20a%20multicentre%20point%20prevalence%20survey%20across%20seven%20hospitals%20in%20Ghana&rft.jtitle=JAC-antimicrobial%20resistance&rft.au=Labi,%20Appiah-Korang&rft.date=2021-09-01&rft.volume=3&rft.issue=3&rft.spage=dlab087&rft.epage=dlab087&rft.pages=dlab087-dlab087&rft.issn=2632-1823&rft.eissn=2632-1823&rft_id=info:doi/10.1093/jacamr/dlab087&rft_dat=%3Cproquest_pubme%3E2552057022%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2552057022&rft_id=info:pmid/34263166&rft_oup_id=10.1093/jacamr/dlab087&rfr_iscdi=true