Zika virus infection enhances future risk of severe dengue disease
The Zika pandemic sparked intense interest in whether immune interactions among dengue virus serotypes 1 to 4 (DENV1 to -4) extend to the closely related Zika virus (ZIKV). We investigated prospective pediatric cohorts in Nicaragua that experienced sequential DENV1 to -3 (2004 to 2015), Zika (2016 t...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2020-08, Vol.369 (6507), p.1123-1128 |
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| creator | Katzelnick, Leah C Narvaez, César Arguello, Sonia Lopez Mercado, Brenda Collado, Damaris Ampie, Oscarlett Elizondo, Douglas Miranda, Tatiana Bustos Carillo, Fausto Mercado, Juan Carlos Latta, Krista Schiller, Amy Segovia-Chumbez, Bruno Ojeda, Sergio Sanchez, Nery Plazaola, Miguel Coloma, Josefina Halloran, M Elizabeth Premkumar, Lakshmanane Gordon, Aubree Narvaez, Federico de Silva, Aravinda M Kuan, Guillermina Balmaseda, Angel Harris, Eva |
| description | The Zika pandemic sparked intense interest in whether immune interactions among dengue virus serotypes 1 to 4 (DENV1 to -4) extend to the closely related Zika virus (ZIKV). We investigated prospective pediatric cohorts in Nicaragua that experienced sequential DENV1 to -3 (2004 to 2015), Zika (2016 to 2017), and DENV2 (2018 to 2020) epidemics. Risk of symptomatic DENV2 infection and severe disease was elevated by one prior ZIKV infection, one prior DENV infection, or one prior DENV infection followed by one ZIKV infection, compared with being flavivirus-naïve. By contrast, multiple prior DENV infections reduced dengue risk. Further, although high preexisting anti-DENV antibody titers protected against DENV1, DENV3, and ZIKV disease, intermediate titers induced by previous ZIKV or DENV infection enhanced future risk of DENV2 disease and severity, as well as DENV3 severity. The observation that prior ZIKV infection can modulate dengue disease severity like a DENV serotype poses challenges to development of dengue and Zika vaccines. |
| doi_str_mv | 10.1126/science.abb6143 |
| format | Article |
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We investigated prospective pediatric cohorts in Nicaragua that experienced sequential DENV1 to -3 (2004 to 2015), Zika (2016 to 2017), and DENV2 (2018 to 2020) epidemics. Risk of symptomatic DENV2 infection and severe disease was elevated by one prior ZIKV infection, one prior DENV infection, or one prior DENV infection followed by one ZIKV infection, compared with being flavivirus-naïve. By contrast, multiple prior DENV infections reduced dengue risk. Further, although high preexisting anti-DENV antibody titers protected against DENV1, DENV3, and ZIKV disease, intermediate titers induced by previous ZIKV or DENV infection enhanced future risk of DENV2 disease and severity, as well as DENV3 severity. The observation that prior ZIKV infection can modulate dengue disease severity like a DENV serotype poses challenges to development of dengue and Zika vaccines.</description><identifier>ISSN: 0036-8075</identifier><identifier>ISSN: 1095-9203</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.abb6143</identifier><identifier>PMID: 32855339</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Antibodies ; Antibodies, Viral - blood ; Dengue fever ; Dengue hemorrhagic fever ; Dengue Vaccines - immunology ; Dengue Virus - immunology ; Epidemics ; Health risks ; Homology ; Humans ; Immunity ; Immunogenicity, Vaccine ; Infections ; Mosquitoes ; Nicaragua - epidemiology ; Pandemics ; Pediatrics ; Risk ; Serogroup ; Serotypes ; Severe Dengue - epidemiology ; Vaccines ; Vector-borne diseases ; Viral envelope proteins ; Viruses ; Zika virus ; Zika Virus - immunology ; Zika Virus Infection - epidemiology ; Zika Virus Infection - immunology</subject><ispartof>Science (American Association for the Advancement of Science), 2020-08, Vol.369 (6507), p.1123-1128</ispartof><rights>Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. 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No claim to original U.S. Government Works</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-80158a0cd11ce30ad54659ea71e607b9bfddb65331e6e105b82361e3cb5779d53</citedby><cites>FETCH-LOGICAL-c487t-80158a0cd11ce30ad54659ea71e607b9bfddb65331e6e105b82361e3cb5779d53</cites><orcidid>0000-0001-7358-982X ; 0000-0002-1736-1350 ; 0000-0002-7238-4037 ; 0000-0003-1033-6758 ; 0000-0002-1000-3665 ; 0000-0002-9584-2571 ; 0000-0002-9352-7877 ; 0000-0002-5218-2702 ; 0000-0002-7730-9386 ; 0000-0002-7263-5625 ; 0000-0002-5637-2239 ; 0000-0002-0878-3260 ; 0000-0003-2512-2306 ; 0000-0002-3127-1757 ; 0000-0003-3317-5950</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,2871,2872,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32855339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katzelnick, Leah C</creatorcontrib><creatorcontrib>Narvaez, César</creatorcontrib><creatorcontrib>Arguello, Sonia</creatorcontrib><creatorcontrib>Lopez Mercado, Brenda</creatorcontrib><creatorcontrib>Collado, Damaris</creatorcontrib><creatorcontrib>Ampie, Oscarlett</creatorcontrib><creatorcontrib>Elizondo, Douglas</creatorcontrib><creatorcontrib>Miranda, Tatiana</creatorcontrib><creatorcontrib>Bustos Carillo, Fausto</creatorcontrib><creatorcontrib>Mercado, Juan Carlos</creatorcontrib><creatorcontrib>Latta, Krista</creatorcontrib><creatorcontrib>Schiller, Amy</creatorcontrib><creatorcontrib>Segovia-Chumbez, Bruno</creatorcontrib><creatorcontrib>Ojeda, Sergio</creatorcontrib><creatorcontrib>Sanchez, Nery</creatorcontrib><creatorcontrib>Plazaola, Miguel</creatorcontrib><creatorcontrib>Coloma, Josefina</creatorcontrib><creatorcontrib>Halloran, M Elizabeth</creatorcontrib><creatorcontrib>Premkumar, Lakshmanane</creatorcontrib><creatorcontrib>Gordon, Aubree</creatorcontrib><creatorcontrib>Narvaez, Federico</creatorcontrib><creatorcontrib>de Silva, Aravinda M</creatorcontrib><creatorcontrib>Kuan, Guillermina</creatorcontrib><creatorcontrib>Balmaseda, Angel</creatorcontrib><creatorcontrib>Harris, Eva</creatorcontrib><title>Zika virus infection enhances future risk of severe dengue disease</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The Zika pandemic sparked intense interest in whether immune interactions among dengue virus serotypes 1 to 4 (DENV1 to -4) extend to the closely related Zika virus (ZIKV). 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The observation that prior ZIKV infection can modulate dengue disease severity like a DENV serotype poses challenges to development of dengue and Zika vaccines.</description><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Dengue fever</subject><subject>Dengue hemorrhagic fever</subject><subject>Dengue Vaccines - immunology</subject><subject>Dengue Virus - immunology</subject><subject>Epidemics</subject><subject>Health risks</subject><subject>Homology</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunogenicity, Vaccine</subject><subject>Infections</subject><subject>Mosquitoes</subject><subject>Nicaragua - epidemiology</subject><subject>Pandemics</subject><subject>Pediatrics</subject><subject>Risk</subject><subject>Serogroup</subject><subject>Serotypes</subject><subject>Severe Dengue - epidemiology</subject><subject>Vaccines</subject><subject>Vector-borne diseases</subject><subject>Viral envelope proteins</subject><subject>Viruses</subject><subject>Zika virus</subject><subject>Zika Virus - 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2020-08, Vol.369 (6507), p.1123-1128 |
| issn | 0036-8075 1095-9203 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8274975 |
| source | American Association for the Advancement of Science; MEDLINE |
| subjects | Antibodies Antibodies, Viral - blood Dengue fever Dengue hemorrhagic fever Dengue Vaccines - immunology Dengue Virus - immunology Epidemics Health risks Homology Humans Immunity Immunogenicity, Vaccine Infections Mosquitoes Nicaragua - epidemiology Pandemics Pediatrics Risk Serogroup Serotypes Severe Dengue - epidemiology Vaccines Vector-borne diseases Viral envelope proteins Viruses Zika virus Zika Virus - immunology Zika Virus Infection - epidemiology Zika Virus Infection - immunology |
| title | Zika virus infection enhances future risk of severe dengue disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T22%3A57%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Zika%20virus%20infection%20enhances%20future%20risk%20of%20severe%20dengue%20disease&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Katzelnick,%20Leah%20C&rft.date=2020-08-28&rft.volume=369&rft.issue=6507&rft.spage=1123&rft.epage=1128&rft.pages=1123-1128&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.abb6143&rft_dat=%3Cproquest_pubme%3E2438014580%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2438014580&rft_id=info:pmid/32855339&rfr_iscdi=true |