MafF Is an Antiviral Host Factor That Suppresses Transcription from Hepatitis B Virus Core Promoter

Hepatitis B virus (HBV) is a stealth virus that exhibits only minimal induction of the interferon system, which is required for both innate and adaptive immune responses. However, 90% of acutely infected adults can clear the virus, suggesting the presence of additional mechanisms that facilitate vir...

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Veröffentlicht in:	Journal of virology 2021-07, Vol.95 (15), p.e0076721-e0076721
Hauptverfasser:	Ibrahim, Marwa K, Abdelhafez, Tawfeek H, Takeuchi, Junko S, Wakae, Kosho, Sugiyama, Masaya, Tsuge, Masataka, Ito, Masahiko, Watashi, Koichi, El Kassas, Mohamed, Kato, Takanobu, Murayama, Asako, Suzuki, Tetsuro, Chayama, Kazuaki, Shimotohno, Kunitada, Muramatsu, Masamichi, Aly, Hussein H, Wakita, Takaji
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor CRISPR-Cas Systems - genetics Hep G2 Cells Hepatitis B virus - genetics Hepatitis B virus - physiology Hepatitis B, Chronic - pathology Humans Immunity, Innate - immunology Interleukin-1beta - immunology MafF Transcription Factor - genetics MafF Transcription Factor - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Promoter Regions, Genetic - genetics RNA Interference RNA, Small Interfering - genetics Transcription, Genetic - genetics Tumor Necrosis Factor-alpha - immunology Virus-Cell Interactions
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