Prevalence of herpes virus in chronic periodontitis patients with and without type 2 diabetes mellitus: A clinico-microbiological study
Background: Unfavorable modifications of tooth and its surrounding structures result in periodontal complications. Viruses, in specific herpes virus, are known to increase disease severity in periodontal patients. Periodontitis is known to be more established in type 2 diabetes mellitus (DM2) patien...
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| Veröffentlicht in: | Journal of oral and maxillofacial pathology : JOMFP 2021-01, Vol.25 (1), p.141-146 |
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| creator | Abooj, Jai Varma, Siddhartha |
| description | Background: Unfavorable modifications of tooth and its surrounding structures result in periodontal complications. Viruses, in specific herpes virus, are known to increase disease severity in periodontal patients. Periodontitis is known to be more established in type 2 diabetes mellitus (DM2) patients. Hence, the detection of the viral load, its effect on the prevalence of periodontitis and the glycemic control status of patients are to be evidenced. The study aimed to reveal the association of herpes virus with periodontal parameters and its prevalence in DM2 patients.
Materials and Methods: The cross-sectional study involved a total of 120 patients falling into three groups; Group I (healthy), Group II (periodontitis without DM2) and Group III (periodontitis with DM2) were subjected for sampling. Subgingival samples of periodontitis patients were tested for clinical parameters, and DNA extraction was performed. The presence of herpes virus (Epstein-Barr virus [EBV-1] and human Cytomegalovirus [HCMV]) was detected using multiplex polymerase chain reaction primers. Glycemic status of patients was recorded as glycosylated hemoglobin and scored accordingly. Chi-square test was performed to analyze the association between the categorical variables, and t-test/Mann-Whitney U-test/analysis of variance/Kruskal-Wallis test was used for continuous data.
Results: Significant levels of EBV-1 were detected in Group III (n = 21, 52.5%), followed by Group II (n = 16, 40%) and Group I (n = 2, 5%) (P < 0.0001). HCMV was not detected. A significant association of EBV-1 to periodontal site-specific parameters was observed in Group II patients (P < 0.05). EBV-1 was predominant with poor glycemic status patients.
Conclusion: This study revealed that the incidence of herpes virus infection in periodontal patients was higher in diabetic patients and the examined patients were prone to EBV-1 infections. |
| doi_str_mv | 10.4103/jomfp.JOMFP_154_20 |
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Materials and Methods: The cross-sectional study involved a total of 120 patients falling into three groups; Group I (healthy), Group II (periodontitis without DM2) and Group III (periodontitis with DM2) were subjected for sampling. Subgingival samples of periodontitis patients were tested for clinical parameters, and DNA extraction was performed. The presence of herpes virus (Epstein-Barr virus [EBV-1] and human Cytomegalovirus [HCMV]) was detected using multiplex polymerase chain reaction primers. Glycemic status of patients was recorded as glycosylated hemoglobin and scored accordingly. Chi-square test was performed to analyze the association between the categorical variables, and t-test/Mann-Whitney U-test/analysis of variance/Kruskal-Wallis test was used for continuous data.
Results: Significant levels of EBV-1 were detected in Group III (n = 21, 52.5%), followed by Group II (n = 16, 40%) and Group I (n = 2, 5%) (P < 0.0001). HCMV was not detected. A significant association of EBV-1 to periodontal site-specific parameters was observed in Group II patients (P < 0.05). EBV-1 was predominant with poor glycemic status patients.
Conclusion: This study revealed that the incidence of herpes virus infection in periodontal patients was higher in diabetic patients and the examined patients were prone to EBV-1 infections.</description><identifier>ISSN: 0973-029X</identifier><identifier>EISSN: 1998-393X</identifier><identifier>DOI: 10.4103/jomfp.JOMFP_154_20</identifier><identifier>PMID: 34349425</identifier><language>eng</language><publisher>Chennai: Wolters Kluwer India Pvt. Ltd</publisher><subject>Cytomegalovirus ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes therapy ; Epstein-Barr virus ; Gum disease ; Hemoglobin ; Herpes ; Herpes viruses ; Herpesvirus diseases ; Original ; Periodontitis ; Polymerase chain reaction ; Prevalence studies (Epidemiology) ; Type 2 diabetes ; Viruses</subject><ispartof>Journal of oral and maxillofacial pathology : JOMFP, 2021-01, Vol.25 (1), p.141-146</ispartof><rights>COPYRIGHT 2021 Medknow Publications and Media Pvt. Ltd.</rights><rights>2021. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © 2021 Journal of Oral and Maxillofacial Pathology 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450n-2262a600978602d7a2c1ac8c3005dc426cda41fb4223087aff74e2675ccd305a3</citedby><cites>FETCH-LOGICAL-c450n-2262a600978602d7a2c1ac8c3005dc426cda41fb4223087aff74e2675ccd305a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272489/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272489/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27458,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Abooj, Jai</creatorcontrib><creatorcontrib>Varma, Siddhartha</creatorcontrib><title>Prevalence of herpes virus in chronic periodontitis patients with and without type 2 diabetes mellitus: A clinico-microbiological study</title><title>Journal of oral and maxillofacial pathology : JOMFP</title><description>Background: Unfavorable modifications of tooth and its surrounding structures result in periodontal complications. Viruses, in specific herpes virus, are known to increase disease severity in periodontal patients. Periodontitis is known to be more established in type 2 diabetes mellitus (DM2) patients. Hence, the detection of the viral load, its effect on the prevalence of periodontitis and the glycemic control status of patients are to be evidenced. The study aimed to reveal the association of herpes virus with periodontal parameters and its prevalence in DM2 patients.
Materials and Methods: The cross-sectional study involved a total of 120 patients falling into three groups; Group I (healthy), Group II (periodontitis without DM2) and Group III (periodontitis with DM2) were subjected for sampling. Subgingival samples of periodontitis patients were tested for clinical parameters, and DNA extraction was performed. The presence of herpes virus (Epstein-Barr virus [EBV-1] and human Cytomegalovirus [HCMV]) was detected using multiplex polymerase chain reaction primers. Glycemic status of patients was recorded as glycosylated hemoglobin and scored accordingly. Chi-square test was performed to analyze the association between the categorical variables, and t-test/Mann-Whitney U-test/analysis of variance/Kruskal-Wallis test was used for continuous data.
Results: Significant levels of EBV-1 were detected in Group III (n = 21, 52.5%), followed by Group II (n = 16, 40%) and Group I (n = 2, 5%) (P < 0.0001). HCMV was not detected. A significant association of EBV-1 to periodontal site-specific parameters was observed in Group II patients (P < 0.05). EBV-1 was predominant with poor glycemic status patients.
Conclusion: This study revealed that the incidence of herpes virus infection in periodontal patients was higher in diabetic patients and the examined patients were prone to EBV-1 infections.</description><subject>Cytomegalovirus</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes therapy</subject><subject>Epstein-Barr virus</subject><subject>Gum disease</subject><subject>Hemoglobin</subject><subject>Herpes</subject><subject>Herpes viruses</subject><subject>Herpesvirus diseases</subject><subject>Original</subject><subject>Periodontitis</subject><subject>Polymerase chain reaction</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Type 2 diabetes</subject><subject>Viruses</subject><issn>0973-029X</issn><issn>1998-393X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9UktvEzEYXCEQDYU_wMkSFy4bvJ_tfXBAigrloaL2AFJvlmN7E6dee7G9ifIL-Ns4TXkUIeSDLXtmPs14iuJ5hee0wuTVxg_9OP90-fn8ileMcsAPilnVdW1JOnL9sJjhriElhu76pHgS4wZj1lIGj4sTQgntKLBZ8f0q6K2w2kmNfI_WOow6oq0JU0TGIbkO3hmJRh2MV94lk0xEo0hGuxTRzqQ1Ek7dHvyUUNqPGgFSRix1ykKDttakKb5GCyStyVK-HIwMfmm89SsjhUUxTWr_tHjUCxv1s7v9tPh6_u7L2Yfy4vL9x7PFRSkpw64EqEHUOBtrawyqESArIVtJsjclKdRSCVr1SwpAcNuIvm-ohrphUiqCmSCnxZuj7jgtB61kthGE5WMwgwh77oXh91-cWfOV3_IWGqBtlwVe3gkE_23SMfHBRJltCqf9FDmwQ8gVrkmGvvgLuvFTcNleRhFoGwaE_Uat8jdw43qf58qDKF_UNWBMALcZNf8HKi-lc57e6d7k-3sEOBJy2DEG3f_yWGF-qA-_rQ__sz6Z9PZI2nmbdIg3dtrpwHMcN87v_sPkFa34zyqRH1150qo</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Abooj, Jai</creator><creator>Varma, Siddhartha</creator><general>Wolters Kluwer India Pvt. 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Viruses, in specific herpes virus, are known to increase disease severity in periodontal patients. Periodontitis is known to be more established in type 2 diabetes mellitus (DM2) patients. Hence, the detection of the viral load, its effect on the prevalence of periodontitis and the glycemic control status of patients are to be evidenced. The study aimed to reveal the association of herpes virus with periodontal parameters and its prevalence in DM2 patients.
Materials and Methods: The cross-sectional study involved a total of 120 patients falling into three groups; Group I (healthy), Group II (periodontitis without DM2) and Group III (periodontitis with DM2) were subjected for sampling. Subgingival samples of periodontitis patients were tested for clinical parameters, and DNA extraction was performed. The presence of herpes virus (Epstein-Barr virus [EBV-1] and human Cytomegalovirus [HCMV]) was detected using multiplex polymerase chain reaction primers. Glycemic status of patients was recorded as glycosylated hemoglobin and scored accordingly. Chi-square test was performed to analyze the association between the categorical variables, and t-test/Mann-Whitney U-test/analysis of variance/Kruskal-Wallis test was used for continuous data.
Results: Significant levels of EBV-1 were detected in Group III (n = 21, 52.5%), followed by Group II (n = 16, 40%) and Group I (n = 2, 5%) (P < 0.0001). HCMV was not detected. A significant association of EBV-1 to periodontal site-specific parameters was observed in Group II patients (P < 0.05). EBV-1 was predominant with poor glycemic status patients.
Conclusion: This study revealed that the incidence of herpes virus infection in periodontal patients was higher in diabetic patients and the examined patients were prone to EBV-1 infections.</abstract><cop>Chennai</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>34349425</pmid><doi>10.4103/jomfp.JOMFP_154_20</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; Medknow Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Cytomegalovirus Diabetes Diabetes mellitus (non-insulin dependent) Diabetes therapy Epstein-Barr virus Gum disease Hemoglobin Herpes Herpes viruses Herpesvirus diseases Original Periodontitis Polymerase chain reaction Prevalence studies (Epidemiology) Type 2 diabetes Viruses |
| title | Prevalence of herpes virus in chronic periodontitis patients with and without type 2 diabetes mellitus: A clinico-microbiological study |
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