Mechanical forces regulate endothelial-to-mesenchymal transition and atherosclerosis via an Alk5-Shc mechanotransduction pathway

The response of endothelial cells to mechanical forces is a critical determinant of vascular health. Vascular pathologies, such as atherosclerosis, characterized by abnormal mechanical forces are frequently accompanied by endothelial-to-mesenchymal transition (EndMT). However, how forces affect the...

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Veröffentlicht in:	Science advances 2021-07, Vol.7 (28)
Hauptverfasser:	Mehta, Vedanta, Pang, Kar-Lai, Givens, Christopher S, Chen, Zhongming, Huang, Jianhua, Sweet, Daniel T, Jo, Hanjoong, Reader, John S, Tzima, Ellie
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Biology Life Sciences SciAdv r-articles Signal Transduction
Online-Zugang:	Volltext
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