Quadrivalent influenza nanoparticle vaccines induce broad protection

Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation and immunization 1 . Here we show that computationally designed, two-component nanoparticle immunogens...

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Veröffentlicht in:	Nature (London) 2021-04, Vol.592 (7855), p.623-628
Hauptverfasser:	Boyoglu-Barnum, Seyhan, Ellis, Daniel, Gillespie, Rebecca A., Hutchinson, Geoffrey B., Park, Young-Jun, Moin, Syed M., Acton, Oliver J., Ravichandran, Rashmi, Murphy, Mike, Pettie, Deleah, Matheson, Nick, Carter, Lauren, Creanga, Adrian, Watson, Michael J., Kephart, Sally, Ataca, Sila, Vaile, John R., Ueda, George, Crank, Michelle C., Stewart, Lance, Lee, Kelly K., Guttman, Miklos, Baker, David, Mascola, John R., Veesler, David, Graham, Barney S., King, Neil P., Kanekiyo, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 13/1 631/250/255/1578 631/250/590/2294 64/60 82/103 82/69 82/80 82/83 Analysis Animal models Animals Antibodies Antibody diversity Antigens Avian flu Broadly Neutralizing Antibodies - immunology Control Design Disease Models, Animal Female Ferrets - immunology Ferrets - virology Global health Glycoproteins Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - immunology Hemagglutinins Humanities and Social Sciences Humans Infections Influenza Influenza A virus - classification Influenza A virus - immunology Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H3N2 Subtype - immunology Influenza vaccines Influenza Vaccines - administration & dosage Influenza Vaccines - chemistry Influenza Vaccines - immunology Influenza viruses Influenza, Human - immunology Influenza, Human - prevention & control Influenza, Human - virology Licenses Male Mass spectrometry Materials Mice Mice, Inbred BALB C Microscopy Models, Molecular Monoclonal antibodies multidisciplinary Nanomedicine Nanoparticles Proteins Public health Science Science (multidisciplinary) Scientific imaging Stems Trimers Vaccines Varieties Viruses
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