Distinct Patterns of HBV Integration and TERT Alterations between in Tumor and Non-Tumor Tissue in Patients with Hepatocellular Carcinoma

Although hepatitis B virus (HBV) integration into the cellular genome is well known in HCC (hepatocellular carcinoma) patients, its biological role still remains uncertain. This study investigated the patterns of HBV integration and correlated them with TERT (telomerase reverse transcriptase) altera...

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Veröffentlicht in:	International journal of molecular sciences 2021-07, Vol.22 (13), p.7056
Hauptverfasser:	Jang, Jeong-Won, Kim, Hye-Seon, Kim, Jin-Seoub, Lee, Soon-Kyu, Han, Ji-Won, Sung, Pil-Soo, Bae, Si-Hyun, Choi, Jong-Young, Yoon, Seung-Kew, Han, Dong-Jin, Kim, Tae-Min, Roberts, Lewis R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Breakpoints Chromosomes Enrichment Genes Genomes Hepatitis B Hepatocellular carcinoma Infections Integration Liver cancer Mutation RNA-directed DNA polymerase Senescence Telomerase Telomerase reverse transcriptase Tumors
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