Efficacy of SPG-ODN 1826 Nanovehicles in Inducing M1 Phenotype through TLR-9 Activation in Murine Alveolar J774A.1 Cells: Plausible Nano-Immunotherapy for Lung Carcinoma

Alveolar macrophages are the first line of defense against intruding pathogens and play a critical role in cancer immunology. The Toll-like receptor (TLR) family mediates an important role in recognizing and mounting an immune response against intruding microbes. TLR-9 is a member of the intracellul...

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Veröffentlicht in:	International journal of molecular sciences 2021-07, Vol.22 (13), p.6833
Hauptverfasser:	Aldawsari, Mohammed F., Alalaiwe, Ahmed, Khafagy, El-Sayed, Al Saqr, Ahmed, Alshahrani, Saad M., Alsulays, Bader B., Alshehri, Sultan, Abu Lila, Amr S., Danish Rizvi, Syed Mohd, Hegazy, Wael A. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Antigens CpG islands Cytokines Endosomes Gene expression Genomes Glucan Growth factors IL-1β Immune response Immune system Immunology Immunostimulation Immunotherapy Inflammation Lipopolysaccharides Localization Lung cancer Lung carcinoma Lymphocytes T Macrophages Medical prognosis Microscopy Morphology NF-κB protein Pathogens Phenotypes Population Proteins Reactive oxygen species TLR9 protein Toll-like receptors Transcription activation β-Glucan γ-Interferon
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