Role of sex hormones in modulating breast and ovarian cancer associated pain
According to the National Cancer Institute in 2020 there will be an estimated 21,750 new ovarian cancer cases and 276,480 new breast cancer cases. Both breast and ovarian cancer are hormone dependent cancers, meaning they cannot grow without the presence of hormones. The two most studied hormones in...
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| Veröffentlicht in: | Molecular and cellular endocrinology 2021-08, Vol.533, p.111320-111320, Article 111320 |
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| container_title | Molecular and cellular endocrinology |
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| creator | McHann, Melissa C. Blanton, Henry L. Guindon, Josée |
| description | According to the National Cancer Institute in 2020 there will be an estimated 21,750 new ovarian cancer cases and 276,480 new breast cancer cases. Both breast and ovarian cancer are hormone dependent cancers, meaning they cannot grow without the presence of hormones. The two most studied hormones in these two cancers are estrogen and progesterone, which are also involved in the modulation of pain. The incidence of pain in breast and ovarian cancer is very high. Research about mechanisms involved in modulation of pain by hormones are still being debated, as some studies find estrogen to be anti-nociceptive and others pro-nociceptive in pain studies. Moreover, analgesic treatments for breast and ovarian cancer-associated pain are limited and often ineffective. In this review, we will focus on estrogen and progesterone mechanisms of action in modulation of pain and cancer. We will also discuss new treatment options for these types of cancer and associated-pain. |
| doi_str_mv | 10.1016/j.mce.2021.111320 |
| format | Article |
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Both breast and ovarian cancer are hormone dependent cancers, meaning they cannot grow without the presence of hormones. The two most studied hormones in these two cancers are estrogen and progesterone, which are also involved in the modulation of pain. The incidence of pain in breast and ovarian cancer is very high. Research about mechanisms involved in modulation of pain by hormones are still being debated, as some studies find estrogen to be anti-nociceptive and others pro-nociceptive in pain studies. Moreover, analgesic treatments for breast and ovarian cancer-associated pain are limited and often ineffective. In this review, we will focus on estrogen and progesterone mechanisms of action in modulation of pain and cancer. 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| ispartof | Molecular and cellular endocrinology, 2021-08, Vol.533, p.111320-111320, Article 111320 |
| issn | 0303-7207 1872-8057 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Analgesics - therapeutic use Breast Breast Neoplasms - complications Breast Neoplasms - metabolism Cancer Cancer Pain - drug therapy Cancer Pain - epidemiology Cancer Pain - metabolism Cannabinoids Estrogen Estrogens - metabolism Female Humans Incidence Molecular Targeted Therapy Ovarian Ovarian Neoplasms - complications Ovarian Neoplasms - metabolism Pain Progesterone Progesterone - metabolism |
| title | Role of sex hormones in modulating breast and ovarian cancer associated pain |
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