Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network
A critical gap in the adoption of genomic medicine into medical practice is the need for the rigorous evaluation of the utility of genomic medicine interventions. The Implementing Genomics in Practice Pragmatic Trials Network (IGNITE PTN) was formed in 2018 to measure the clinical utility and cost-e...
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| Veröffentlicht in: | Genetics in medicine 2021-07, Vol.23 (7), p.1185-1191 |
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| creator | Ginsburg, Geoffrey S. Cavallari, Larisa H. Chakraborty, Hrishikesh Cooper-DeHoff, Rhonda M. Dexter, Paul R. Eadon, Michael T. Ferket, Bart S. Horowitz, Carol R. Johnson, Julie A. Kannry, Joseph Kucher, Natalie Madden, Ebony B. Orlando, Lori A. Parker, Wanda Peterson, Josh Pratt, Victoria M. Rakhra-Burris, Tejinder K. Ramos, Michelle A. Skaar, Todd C. Sperber, Nina Steen-Burrell, Kady-Ann Van Driest, Sara L. Voora, Deepak Wiisanen, Kristin Winterstein, Almut G. Volpi, Simona Montgomery, Aisha Kitzman, Heather Sadeghpour, Azita Voora, Deepak Ginsburg, Geoffrey S. Chakraborty, Hrishikesh Steen-Burrell, Kady-Ann Orlando, Lori A. Garrett-Mead, Nancy Sperber, Nina Wu, R. Ryanne Rakhra-Burris, Tejinder Parker, Wanda Eadon, Michael T. Dexter, Paul Lynch, Sheryl Skaar, Todd Pratt, Victoria Nauman, Beth Johnson, Erica Ferket, Bart Horowitz, Carol R. Hauser, Diane Kannry, Joseph Ramos, Michelle Ferket, Mart Shroff, Nandini Calman, Neil Clermont, Sabrina Shuman, Saskia Singh, Rajbir Madden, Ebony Kucher, Natalie Volpi, Simona Blake, Kathryn Duong, Benjamin Quang Free, Colette Hines, Lindsay Roberts, Joseph Winterstein, Almut G. Elsey, Amanda Elwood, Erica Johnson, Julie Wiisanen, Kristin Cavallari, Larisa Cooper-DeHoff, Rhonda Parker, Alex Vigal, Kim Fuloria, Jyotsna Revels, Asa Beasley, Cherry Ong, Henry Peterson, Josh Cavanaugh, Kerri Van Driest, Sara |
| description | A critical gap in the adoption of genomic medicine into medical practice is the need for the rigorous evaluation of the utility of genomic medicine interventions.
The Implementing Genomics in Practice Pragmatic Trials Network (IGNITE PTN) was formed in 2018 to measure the clinical utility and cost-effectiveness of genomic medicine interventions, to assess approaches for real-world application of genomic medicine in diverse clinical settings, and to produce generalizable knowledge on clinical trials using genomic interventions. Five clinical sites and a coordinating center evaluated trial proposals and developed working groups to enable their implementation.
Two pragmatic clinical trials (PCTs) have been initiated, one evaluating genetic risk APOL1 variants in African Americans in the management of their hypertension, and the other to evaluate the use of pharmacogenetic testing for medications to manage acute and chronic pain as well as depression.
IGNITE PTN is a network that carries out PCTs in genomic medicine; it is focused on diversity and inclusion of underrepresented minority trial participants; it uses electronic health records and clinical decision support to deliver the interventions. IGNITE PTN will develop the evidence to support (or oppose) the adoption of genomic medicine interventions by patients, providers, and payers. |
| doi_str_mv | 10.1038/s41436-021-01118-9 |
| format | Article |
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The Implementing Genomics in Practice Pragmatic Trials Network (IGNITE PTN) was formed in 2018 to measure the clinical utility and cost-effectiveness of genomic medicine interventions, to assess approaches for real-world application of genomic medicine in diverse clinical settings, and to produce generalizable knowledge on clinical trials using genomic interventions. Five clinical sites and a coordinating center evaluated trial proposals and developed working groups to enable their implementation.
Two pragmatic clinical trials (PCTs) have been initiated, one evaluating genetic risk APOL1 variants in African Americans in the management of their hypertension, and the other to evaluate the use of pharmacogenetic testing for medications to manage acute and chronic pain as well as depression.
IGNITE PTN is a network that carries out PCTs in genomic medicine; it is focused on diversity and inclusion of underrepresented minority trial participants; it uses electronic health records and clinical decision support to deliver the interventions. IGNITE PTN will develop the evidence to support (or oppose) the adoption of genomic medicine interventions by patients, providers, and payers.</description><identifier>ISSN: 1098-3600</identifier><identifier>EISSN: 1530-0366</identifier><identifier>DOI: 10.1038/s41436-021-01118-9</identifier><identifier>PMID: 33782552</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Apolipoprotein L1 ; Biomedical and Life Sciences ; Biomedicine ; Clinical trials ; Decision Support Systems, Clinical ; Electronic Health Records ; Genomics ; Human Genetics ; Humans ; Laboratory Medicine ; Medicine ; Pharmacogenomic Testing ; Precision Medicine</subject><ispartof>Genetics in medicine, 2021-07, Vol.23 (7), p.1185-1191</ispartof><rights>2021 The Author(s)</rights><rights>The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics 2021</rights><rights>The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-625c034aafbb74980ce21760a2e92fc47a2f43ffec13112d9f0e032e6f9de7903</citedby><cites>FETCH-LOGICAL-c527t-625c034aafbb74980ce21760a2e92fc47a2f43ffec13112d9f0e032e6f9de7903</cites><orcidid>0000-0003-4739-9808</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33782552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ginsburg, Geoffrey S.</creatorcontrib><creatorcontrib>Cavallari, Larisa H.</creatorcontrib><creatorcontrib>Chakraborty, Hrishikesh</creatorcontrib><creatorcontrib>Cooper-DeHoff, Rhonda M.</creatorcontrib><creatorcontrib>Dexter, Paul R.</creatorcontrib><creatorcontrib>Eadon, Michael T.</creatorcontrib><creatorcontrib>Ferket, Bart S.</creatorcontrib><creatorcontrib>Horowitz, Carol R.</creatorcontrib><creatorcontrib>Johnson, Julie A.</creatorcontrib><creatorcontrib>Kannry, Joseph</creatorcontrib><creatorcontrib>Kucher, Natalie</creatorcontrib><creatorcontrib>Madden, Ebony B.</creatorcontrib><creatorcontrib>Orlando, Lori A.</creatorcontrib><creatorcontrib>Parker, Wanda</creatorcontrib><creatorcontrib>Peterson, Josh</creatorcontrib><creatorcontrib>Pratt, Victoria M.</creatorcontrib><creatorcontrib>Rakhra-Burris, Tejinder K.</creatorcontrib><creatorcontrib>Ramos, Michelle A.</creatorcontrib><creatorcontrib>Skaar, Todd C.</creatorcontrib><creatorcontrib>Sperber, Nina</creatorcontrib><creatorcontrib>Steen-Burrell, Kady-Ann</creatorcontrib><creatorcontrib>Van Driest, Sara L.</creatorcontrib><creatorcontrib>Voora, Deepak</creatorcontrib><creatorcontrib>Wiisanen, Kristin</creatorcontrib><creatorcontrib>Winterstein, Almut G.</creatorcontrib><creatorcontrib>Volpi, Simona</creatorcontrib><creatorcontrib>Montgomery, Aisha</creatorcontrib><creatorcontrib>Kitzman, Heather</creatorcontrib><creatorcontrib>Sadeghpour, Azita</creatorcontrib><creatorcontrib>Voora, Deepak</creatorcontrib><creatorcontrib>Ginsburg, Geoffrey S.</creatorcontrib><creatorcontrib>Chakraborty, Hrishikesh</creatorcontrib><creatorcontrib>Steen-Burrell, Kady-Ann</creatorcontrib><creatorcontrib>Orlando, Lori A.</creatorcontrib><creatorcontrib>Garrett-Mead, Nancy</creatorcontrib><creatorcontrib>Sperber, Nina</creatorcontrib><creatorcontrib>Wu, R. Ryanne</creatorcontrib><creatorcontrib>Rakhra-Burris, Tejinder</creatorcontrib><creatorcontrib>Parker, Wanda</creatorcontrib><creatorcontrib>Eadon, Michael T.</creatorcontrib><creatorcontrib>Dexter, Paul</creatorcontrib><creatorcontrib>Lynch, Sheryl</creatorcontrib><creatorcontrib>Skaar, Todd</creatorcontrib><creatorcontrib>Pratt, Victoria</creatorcontrib><creatorcontrib>Nauman, Beth</creatorcontrib><creatorcontrib>Johnson, Erica</creatorcontrib><creatorcontrib>Ferket, Bart</creatorcontrib><creatorcontrib>Horowitz, Carol R.</creatorcontrib><creatorcontrib>Hauser, Diane</creatorcontrib><creatorcontrib>Kannry, Joseph</creatorcontrib><creatorcontrib>Ramos, Michelle</creatorcontrib><creatorcontrib>Ferket, Mart</creatorcontrib><creatorcontrib>Shroff, Nandini</creatorcontrib><creatorcontrib>Calman, Neil</creatorcontrib><creatorcontrib>Clermont, Sabrina</creatorcontrib><creatorcontrib>Shuman, Saskia</creatorcontrib><creatorcontrib>Singh, Rajbir</creatorcontrib><creatorcontrib>Madden, Ebony</creatorcontrib><creatorcontrib>Kucher, Natalie</creatorcontrib><creatorcontrib>Volpi, Simona</creatorcontrib><creatorcontrib>Blake, Kathryn</creatorcontrib><creatorcontrib>Duong, Benjamin Quang</creatorcontrib><creatorcontrib>Free, Colette</creatorcontrib><creatorcontrib>Hines, Lindsay</creatorcontrib><creatorcontrib>Roberts, Joseph</creatorcontrib><creatorcontrib>Winterstein, Almut G.</creatorcontrib><creatorcontrib>Elsey, Amanda</creatorcontrib><creatorcontrib>Elwood, Erica</creatorcontrib><creatorcontrib>Johnson, Julie</creatorcontrib><creatorcontrib>Wiisanen, Kristin</creatorcontrib><creatorcontrib>Cavallari, Larisa</creatorcontrib><creatorcontrib>Cooper-DeHoff, Rhonda</creatorcontrib><creatorcontrib>Parker, Alex</creatorcontrib><creatorcontrib>Vigal, Kim</creatorcontrib><creatorcontrib>Fuloria, Jyotsna</creatorcontrib><creatorcontrib>Revels, Asa</creatorcontrib><creatorcontrib>Beasley, Cherry</creatorcontrib><creatorcontrib>Ong, Henry</creatorcontrib><creatorcontrib>Peterson, Josh</creatorcontrib><creatorcontrib>Cavanaugh, Kerri</creatorcontrib><creatorcontrib>Van Driest, Sara</creatorcontrib><creatorcontrib>the IGNITE PTN</creatorcontrib><creatorcontrib>IGNITE PTN</creatorcontrib><title>Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network</title><title>Genetics in medicine</title><addtitle>Genet Med</addtitle><addtitle>Genet Med</addtitle><description>A critical gap in the adoption of genomic medicine into medical practice is the need for the rigorous evaluation of the utility of genomic medicine interventions.
The Implementing Genomics in Practice Pragmatic Trials Network (IGNITE PTN) was formed in 2018 to measure the clinical utility and cost-effectiveness of genomic medicine interventions, to assess approaches for real-world application of genomic medicine in diverse clinical settings, and to produce generalizable knowledge on clinical trials using genomic interventions. Five clinical sites and a coordinating center evaluated trial proposals and developed working groups to enable their implementation.
Two pragmatic clinical trials (PCTs) have been initiated, one evaluating genetic risk APOL1 variants in African Americans in the management of their hypertension, and the other to evaluate the use of pharmacogenetic testing for medications to manage acute and chronic pain as well as depression.
IGNITE PTN is a network that carries out PCTs in genomic medicine; it is focused on diversity and inclusion of underrepresented minority trial participants; it uses electronic health records and clinical decision support to deliver the interventions. IGNITE PTN will develop the evidence to support (or oppose) the adoption of genomic medicine interventions by patients, providers, and payers.</description><subject>Apolipoprotein L1</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Clinical trials</subject><subject>Decision Support Systems, Clinical</subject><subject>Electronic Health Records</subject><subject>Genomics</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Medicine</subject><subject>Pharmacogenomic Testing</subject><subject>Precision Medicine</subject><issn>1098-3600</issn><issn>1530-0366</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUtv1DAUhSMEog_4AyyQJTZsQq8feRghJFQNZaSqIDGsLY_nOuOS2K2dDOq_x23aQrvoyrbud47P1SmKNxQ-UODtURJU8LoERkuglLalfFbs04pDCbyun-c7yLbkNcBecZDSOQBtOIOXxR7nTcuqiu0XPxdp1Ovepa3zHRm3SHa6n5AESzr0YXAmEefJgBtnnMePN8jy5Gy5WpAfUXeDHp0hq-h0n8gZjn9C_P2qeGHzE1_fnofFr6-L1fG38vT7yfL4y2lpKtaMZc0qA1xobdfrRsgWDDLa1KAZSmaNaDSzgluLhnJK2UZaQOAMays32Ejgh8Xn2fdiWueABv0Yda8uoht0vFJBO_Vw4t1WdWGnWlZz0V4bvL81iOFywjSqwSWDfa89hikpVkFDRcOEyOi7R-h5mKLP62VKtLyVOWKm2EyZGFKKaO_DUFDXnam5M5U7UzedKZlFb_9f415yV1IG-AykPPIdxn9_P2n7aVZhrmDnsioZh97kJiOaUW2Ce0r-FyYrtPw</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Ginsburg, Geoffrey S.</creator><creator>Cavallari, Larisa H.</creator><creator>Chakraborty, Hrishikesh</creator><creator>Cooper-DeHoff, Rhonda M.</creator><creator>Dexter, Paul R.</creator><creator>Eadon, Michael T.</creator><creator>Ferket, Bart S.</creator><creator>Horowitz, Carol R.</creator><creator>Johnson, Julie A.</creator><creator>Kannry, Joseph</creator><creator>Kucher, Natalie</creator><creator>Madden, Ebony B.</creator><creator>Orlando, Lori A.</creator><creator>Parker, Wanda</creator><creator>Peterson, Josh</creator><creator>Pratt, Victoria M.</creator><creator>Rakhra-Burris, Tejinder K.</creator><creator>Ramos, Michelle A.</creator><creator>Skaar, Todd C.</creator><creator>Sperber, Nina</creator><creator>Steen-Burrell, Kady-Ann</creator><creator>Van Driest, Sara L.</creator><creator>Voora, Deepak</creator><creator>Wiisanen, Kristin</creator><creator>Winterstein, Almut G.</creator><creator>Volpi, Simona</creator><creator>Montgomery, Aisha</creator><creator>Kitzman, Heather</creator><creator>Sadeghpour, Azita</creator><creator>Voora, Deepak</creator><creator>Ginsburg, Geoffrey S.</creator><creator>Chakraborty, Hrishikesh</creator><creator>Steen-Burrell, Kady-Ann</creator><creator>Orlando, Lori A.</creator><creator>Garrett-Mead, Nancy</creator><creator>Sperber, Nina</creator><creator>Wu, R. 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Ryanne ; Rakhra-Burris, Tejinder ; Parker, Wanda ; Eadon, Michael T. ; Dexter, Paul ; Lynch, Sheryl ; Skaar, Todd ; Pratt, Victoria ; Nauman, Beth ; Johnson, Erica ; Ferket, Bart ; Horowitz, Carol R. ; Hauser, Diane ; Kannry, Joseph ; Ramos, Michelle ; Ferket, Mart ; Shroff, Nandini ; Calman, Neil ; Clermont, Sabrina ; Shuman, Saskia ; Singh, Rajbir ; Madden, Ebony ; Kucher, Natalie ; Volpi, Simona ; Blake, Kathryn ; Duong, Benjamin Quang ; Free, Colette ; Hines, Lindsay ; Roberts, Joseph ; Winterstein, Almut G. ; Elsey, Amanda ; Elwood, Erica ; Johnson, Julie ; Wiisanen, Kristin ; Cavallari, Larisa ; Cooper-DeHoff, Rhonda ; Parker, Alex ; Vigal, Kim ; Fuloria, Jyotsna ; Revels, Asa ; Beasley, Cherry ; Ong, Henry ; Peterson, Josh ; Cavanaugh, Kerri ; Van Driest, Sara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-625c034aafbb74980ce21760a2e92fc47a2f43ffec13112d9f0e032e6f9de7903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Apolipoprotein L1</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Clinical trials</topic><topic>Decision Support Systems, Clinical</topic><topic>Electronic Health Records</topic><topic>Genomics</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Laboratory Medicine</topic><topic>Medicine</topic><topic>Pharmacogenomic Testing</topic><topic>Precision Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ginsburg, Geoffrey S.</creatorcontrib><creatorcontrib>Cavallari, Larisa H.</creatorcontrib><creatorcontrib>Chakraborty, Hrishikesh</creatorcontrib><creatorcontrib>Cooper-DeHoff, Rhonda M.</creatorcontrib><creatorcontrib>Dexter, Paul R.</creatorcontrib><creatorcontrib>Eadon, Michael T.</creatorcontrib><creatorcontrib>Ferket, Bart S.</creatorcontrib><creatorcontrib>Horowitz, Carol R.</creatorcontrib><creatorcontrib>Johnson, Julie A.</creatorcontrib><creatorcontrib>Kannry, Joseph</creatorcontrib><creatorcontrib>Kucher, Natalie</creatorcontrib><creatorcontrib>Madden, Ebony B.</creatorcontrib><creatorcontrib>Orlando, Lori A.</creatorcontrib><creatorcontrib>Parker, Wanda</creatorcontrib><creatorcontrib>Peterson, Josh</creatorcontrib><creatorcontrib>Pratt, Victoria M.</creatorcontrib><creatorcontrib>Rakhra-Burris, Tejinder K.</creatorcontrib><creatorcontrib>Ramos, Michelle A.</creatorcontrib><creatorcontrib>Skaar, Todd C.</creatorcontrib><creatorcontrib>Sperber, Nina</creatorcontrib><creatorcontrib>Steen-Burrell, Kady-Ann</creatorcontrib><creatorcontrib>Van Driest, Sara L.</creatorcontrib><creatorcontrib>Voora, Deepak</creatorcontrib><creatorcontrib>Wiisanen, Kristin</creatorcontrib><creatorcontrib>Winterstein, Almut G.</creatorcontrib><creatorcontrib>Volpi, Simona</creatorcontrib><creatorcontrib>Montgomery, Aisha</creatorcontrib><creatorcontrib>Kitzman, Heather</creatorcontrib><creatorcontrib>Sadeghpour, Azita</creatorcontrib><creatorcontrib>Voora, Deepak</creatorcontrib><creatorcontrib>Ginsburg, Geoffrey S.</creatorcontrib><creatorcontrib>Chakraborty, Hrishikesh</creatorcontrib><creatorcontrib>Steen-Burrell, Kady-Ann</creatorcontrib><creatorcontrib>Orlando, Lori A.</creatorcontrib><creatorcontrib>Garrett-Mead, Nancy</creatorcontrib><creatorcontrib>Sperber, Nina</creatorcontrib><creatorcontrib>Wu, R. Ryanne</creatorcontrib><creatorcontrib>Rakhra-Burris, Tejinder</creatorcontrib><creatorcontrib>Parker, Wanda</creatorcontrib><creatorcontrib>Eadon, Michael T.</creatorcontrib><creatorcontrib>Dexter, Paul</creatorcontrib><creatorcontrib>Lynch, Sheryl</creatorcontrib><creatorcontrib>Skaar, Todd</creatorcontrib><creatorcontrib>Pratt, Victoria</creatorcontrib><creatorcontrib>Nauman, Beth</creatorcontrib><creatorcontrib>Johnson, Erica</creatorcontrib><creatorcontrib>Ferket, Bart</creatorcontrib><creatorcontrib>Horowitz, Carol R.</creatorcontrib><creatorcontrib>Hauser, Diane</creatorcontrib><creatorcontrib>Kannry, Joseph</creatorcontrib><creatorcontrib>Ramos, Michelle</creatorcontrib><creatorcontrib>Ferket, Mart</creatorcontrib><creatorcontrib>Shroff, Nandini</creatorcontrib><creatorcontrib>Calman, Neil</creatorcontrib><creatorcontrib>Clermont, Sabrina</creatorcontrib><creatorcontrib>Shuman, Saskia</creatorcontrib><creatorcontrib>Singh, Rajbir</creatorcontrib><creatorcontrib>Madden, Ebony</creatorcontrib><creatorcontrib>Kucher, Natalie</creatorcontrib><creatorcontrib>Volpi, Simona</creatorcontrib><creatorcontrib>Blake, Kathryn</creatorcontrib><creatorcontrib>Duong, Benjamin Quang</creatorcontrib><creatorcontrib>Free, Colette</creatorcontrib><creatorcontrib>Hines, Lindsay</creatorcontrib><creatorcontrib>Roberts, Joseph</creatorcontrib><creatorcontrib>Winterstein, Almut G.</creatorcontrib><creatorcontrib>Elsey, Amanda</creatorcontrib><creatorcontrib>Elwood, Erica</creatorcontrib><creatorcontrib>Johnson, Julie</creatorcontrib><creatorcontrib>Wiisanen, Kristin</creatorcontrib><creatorcontrib>Cavallari, Larisa</creatorcontrib><creatorcontrib>Cooper-DeHoff, Rhonda</creatorcontrib><creatorcontrib>Parker, Alex</creatorcontrib><creatorcontrib>Vigal, Kim</creatorcontrib><creatorcontrib>Fuloria, Jyotsna</creatorcontrib><creatorcontrib>Revels, Asa</creatorcontrib><creatorcontrib>Beasley, Cherry</creatorcontrib><creatorcontrib>Ong, Henry</creatorcontrib><creatorcontrib>Peterson, Josh</creatorcontrib><creatorcontrib>Cavanaugh, Kerri</creatorcontrib><creatorcontrib>Van Driest, Sara</creatorcontrib><creatorcontrib>the IGNITE PTN</creatorcontrib><creatorcontrib>IGNITE PTN</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genetics in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ginsburg, Geoffrey S.</au><au>Cavallari, Larisa H.</au><au>Chakraborty, Hrishikesh</au><au>Cooper-DeHoff, Rhonda M.</au><au>Dexter, Paul R.</au><au>Eadon, Michael T.</au><au>Ferket, Bart S.</au><au>Horowitz, Carol R.</au><au>Johnson, Julie A.</au><au>Kannry, Joseph</au><au>Kucher, Natalie</au><au>Madden, Ebony B.</au><au>Orlando, Lori A.</au><au>Parker, Wanda</au><au>Peterson, Josh</au><au>Pratt, Victoria M.</au><au>Rakhra-Burris, Tejinder K.</au><au>Ramos, Michelle A.</au><au>Skaar, Todd C.</au><au>Sperber, Nina</au><au>Steen-Burrell, Kady-Ann</au><au>Van Driest, Sara L.</au><au>Voora, Deepak</au><au>Wiisanen, Kristin</au><au>Winterstein, Almut G.</au><au>Volpi, Simona</au><au>Montgomery, Aisha</au><au>Kitzman, Heather</au><au>Sadeghpour, Azita</au><au>Voora, Deepak</au><au>Ginsburg, Geoffrey S.</au><au>Chakraborty, Hrishikesh</au><au>Steen-Burrell, Kady-Ann</au><au>Orlando, Lori A.</au><au>Garrett-Mead, Nancy</au><au>Sperber, Nina</au><au>Wu, R. Ryanne</au><au>Rakhra-Burris, Tejinder</au><au>Parker, Wanda</au><au>Eadon, Michael T.</au><au>Dexter, Paul</au><au>Lynch, Sheryl</au><au>Skaar, Todd</au><au>Pratt, Victoria</au><au>Nauman, Beth</au><au>Johnson, Erica</au><au>Ferket, Bart</au><au>Horowitz, Carol R.</au><au>Hauser, Diane</au><au>Kannry, Joseph</au><au>Ramos, Michelle</au><au>Ferket, Mart</au><au>Shroff, Nandini</au><au>Calman, Neil</au><au>Clermont, Sabrina</au><au>Shuman, Saskia</au><au>Singh, Rajbir</au><au>Madden, Ebony</au><au>Kucher, Natalie</au><au>Volpi, Simona</au><au>Blake, Kathryn</au><au>Duong, Benjamin Quang</au><au>Free, Colette</au><au>Hines, Lindsay</au><au>Roberts, Joseph</au><au>Winterstein, Almut G.</au><au>Elsey, Amanda</au><au>Elwood, Erica</au><au>Johnson, Julie</au><au>Wiisanen, Kristin</au><au>Cavallari, Larisa</au><au>Cooper-DeHoff, Rhonda</au><au>Parker, Alex</au><au>Vigal, Kim</au><au>Fuloria, Jyotsna</au><au>Revels, Asa</au><au>Beasley, Cherry</au><au>Ong, Henry</au><au>Peterson, Josh</au><au>Cavanaugh, Kerri</au><au>Van Driest, Sara</au><aucorp>the IGNITE PTN</aucorp><aucorp>IGNITE PTN</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network</atitle><jtitle>Genetics in medicine</jtitle><stitle>Genet Med</stitle><addtitle>Genet Med</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>23</volume><issue>7</issue><spage>1185</spage><epage>1191</epage><pages>1185-1191</pages><issn>1098-3600</issn><eissn>1530-0366</eissn><abstract>A critical gap in the adoption of genomic medicine into medical practice is the need for the rigorous evaluation of the utility of genomic medicine interventions.
The Implementing Genomics in Practice Pragmatic Trials Network (IGNITE PTN) was formed in 2018 to measure the clinical utility and cost-effectiveness of genomic medicine interventions, to assess approaches for real-world application of genomic medicine in diverse clinical settings, and to produce generalizable knowledge on clinical trials using genomic interventions. Five clinical sites and a coordinating center evaluated trial proposals and developed working groups to enable their implementation.
Two pragmatic clinical trials (PCTs) have been initiated, one evaluating genetic risk APOL1 variants in African Americans in the management of their hypertension, and the other to evaluate the use of pharmacogenetic testing for medications to manage acute and chronic pain as well as depression.
IGNITE PTN is a network that carries out PCTs in genomic medicine; it is focused on diversity and inclusion of underrepresented minority trial participants; it uses electronic health records and clinical decision support to deliver the interventions. IGNITE PTN will develop the evidence to support (or oppose) the adoption of genomic medicine interventions by patients, providers, and payers.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>33782552</pmid><doi>10.1038/s41436-021-01118-9</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4739-9808</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1098-3600 |
| ispartof | Genetics in medicine, 2021-07, Vol.23 (7), p.1185-1191 |
| issn | 1098-3600 1530-0366 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8263480 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Apolipoprotein L1 Biomedical and Life Sciences Biomedicine Clinical trials Decision Support Systems, Clinical Electronic Health Records Genomics Human Genetics Humans Laboratory Medicine Medicine Pharmacogenomic Testing Precision Medicine |
| title | Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network |
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