A comparative cross-sectional study on sleep quality in patients with a history of differentiated thyroid carcinoma and its correlation with quality of life
Purpose To evaluate sleep quality in differentiated thyroid carcinoma (DTC) patients and correlate sleep disturbances with quality of life (QoL). Methods 119 DTC patients were enrolled (DTC group). The Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI) inventories were admin...
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| Veröffentlicht in: | Endocrine 2021-08, Vol.73 (2), p.347-357 |
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| container_title | Endocrine |
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| creator | Teliti, Marsida Monti, Eleonora Comina, Martina Conte, Lucia Vera, Lara Gay, Stefano Saccomani, Giorgia Ferone, Diego Giusti, Massimo |
| description | Purpose
To evaluate sleep quality in differentiated thyroid carcinoma (DTC) patients and correlate sleep disturbances with quality of life (QoL).
Methods
119 DTC patients were enrolled (DTC group). The Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI) inventories were administered. The Thyroid-specific Patient-Reported Outcome (ThyPRO) questionnaire, the Billewicz scale (BS) and an ad-hoc visual analogic scale (VAS) were used to measure QoL and subjective therapy-related complaints. The same examinations were conducted in 53 subjects (control group) who had undergone surgery for benign thyroid pathology.
Results
L-T4 dosages and TSH levels differed between the groups. BS and VAS scores were comparable. PSQI documented a similar percentage of poor sleepers in the DTC (74%) and control (62%) groups. ISI showed no difference in subjects without clinically significant insomnia: DTC (43%) and controls (48%). ThyPRO showed significantly worse scores in DTC than control subjects. In DTC patients, PSQI (
P
= 0.002) and ISI (
P
= 0.04) correlated significantly with age. In control subjects, TSH displayed a significant positive association with PSQI (
P
= 0.02) and ISI (
P
|
| doi_str_mv | 10.1007/s12020-020-02591-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8263451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2486467574</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-5d0de49ffc263b1532ca283a3a35c14f2e5d17a7f1778e7f6f603f3c2db22b063</originalsourceid><addsrcrecordid>eNp9kU1rFTEUhgdRbK3-ARcScONmNJ-TmY1QilWh4EbBXchNTnpTZia3SaZy-1v8sT112vqxkBASOM_7npO8TfOS0beMUv2uME45bdetBtZeP2oOmVJDS7H-GO9CqZbS_vtB86yUC0o5551-2hwIoYQelDpsfh4Tl6adzbbGKyAup1LaAq7GNNuRlLr4PUkzKSPAjlwudox1T-JMdiiAuRbyI9YtsWQbS00Z2UB8DAEyFqOt4End7nOKnjibXZzTZImdPYkodSlnGO1tr9Xm3h9NxhjgefMk2LHAi7vzqPl2-uHryaf27MvHzyfHZ62TWtZWeepBDiE43okNU4I7y3thcSnHZOCgPNNWB6Z1Dzp0oaMiCMf9hvMN7cRR83713S2bCbzD0bMdzS7Hyea9STaavytz3JrzdGV6bCgVQ4M3dwY5XS5QqplicTCOdoa0FMNl38lOKy0Rff0PepGWjH-NlJIDF5J2PVJ8pX4FkiE8DMOouQ3frOGbdWP45hpFr_58xoPkPm0ExAoULM3nkH_3_o_tDZ_Hv7U</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2549234068</pqid></control><display><type>article</type><title>A comparative cross-sectional study on sleep quality in patients with a history of differentiated thyroid carcinoma and its correlation with quality of life</title><source>SpringerLink Journals - AutoHoldings</source><creator>Teliti, Marsida ; Monti, Eleonora ; Comina, Martina ; Conte, Lucia ; Vera, Lara ; Gay, Stefano ; Saccomani, Giorgia ; Ferone, Diego ; Giusti, Massimo</creator><creatorcontrib>Teliti, Marsida ; Monti, Eleonora ; Comina, Martina ; Conte, Lucia ; Vera, Lara ; Gay, Stefano ; Saccomani, Giorgia ; Ferone, Diego ; Giusti, Massimo</creatorcontrib><description>Purpose
To evaluate sleep quality in differentiated thyroid carcinoma (DTC) patients and correlate sleep disturbances with quality of life (QoL).
Methods
119 DTC patients were enrolled (DTC group). The Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI) inventories were administered. The Thyroid-specific Patient-Reported Outcome (ThyPRO) questionnaire, the Billewicz scale (BS) and an ad-hoc visual analogic scale (VAS) were used to measure QoL and subjective therapy-related complaints. The same examinations were conducted in 53 subjects (control group) who had undergone surgery for benign thyroid pathology.
Results
L-T4 dosages and TSH levels differed between the groups. BS and VAS scores were comparable. PSQI documented a similar percentage of poor sleepers in the DTC (74%) and control (62%) groups. ISI showed no difference in subjects without clinically significant insomnia: DTC (43%) and controls (48%). ThyPRO showed significantly worse scores in DTC than control subjects. In DTC patients, PSQI (
P
= 0.002) and ISI (
P
= 0.04) correlated significantly with age. In control subjects, TSH displayed a significant positive association with PSQI (
P
= 0.02) and ISI (
P
< 0.05). The ThyPRO general score correlated significantly with PSQI in DTC patients. In both groups, ISI correlated significantly with several ThyPRO scales and the ThyPRO general score. “Anxiety” and “emotional susceptibility” were the scales most significantly related with PSQI and ISI.
Conclusion
In disease-free DTC patients and subjects who undergo thyroid surgery for benign pathology, abnormal sleep components and insomnia are similar. The ThyPRO questionnaire closely reflects sleep disturbances in all subjects. Recognising and treating sleep disturbances might improve QoL.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-020-02591-z</identifier><identifier>PMID: 33537955</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cross-sectional studies ; Diabetes ; Endocrinology ; Humanities and Social Sciences ; Insomnia ; Internal Medicine ; Medicine ; Medicine & Public Health ; multidisciplinary ; Original ; Original Article ; Patients ; Quality of life ; Questionnaires ; Science ; Sleep ; Sleep disorders ; Surgery ; Thyroid cancer ; Thyroid carcinoma ; Thyroid-stimulating hormone ; Thyroxine</subject><ispartof>Endocrine, 2021-08, Vol.73 (2), p.347-357</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-5d0de49ffc263b1532ca283a3a35c14f2e5d17a7f1778e7f6f603f3c2db22b063</citedby><cites>FETCH-LOGICAL-c474t-5d0de49ffc263b1532ca283a3a35c14f2e5d17a7f1778e7f6f603f3c2db22b063</cites><orcidid>0000-0002-1410-6143</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-020-02591-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-020-02591-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33537955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teliti, Marsida</creatorcontrib><creatorcontrib>Monti, Eleonora</creatorcontrib><creatorcontrib>Comina, Martina</creatorcontrib><creatorcontrib>Conte, Lucia</creatorcontrib><creatorcontrib>Vera, Lara</creatorcontrib><creatorcontrib>Gay, Stefano</creatorcontrib><creatorcontrib>Saccomani, Giorgia</creatorcontrib><creatorcontrib>Ferone, Diego</creatorcontrib><creatorcontrib>Giusti, Massimo</creatorcontrib><title>A comparative cross-sectional study on sleep quality in patients with a history of differentiated thyroid carcinoma and its correlation with quality of life</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Purpose
To evaluate sleep quality in differentiated thyroid carcinoma (DTC) patients and correlate sleep disturbances with quality of life (QoL).
Methods
119 DTC patients were enrolled (DTC group). The Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI) inventories were administered. The Thyroid-specific Patient-Reported Outcome (ThyPRO) questionnaire, the Billewicz scale (BS) and an ad-hoc visual analogic scale (VAS) were used to measure QoL and subjective therapy-related complaints. The same examinations were conducted in 53 subjects (control group) who had undergone surgery for benign thyroid pathology.
Results
L-T4 dosages and TSH levels differed between the groups. BS and VAS scores were comparable. PSQI documented a similar percentage of poor sleepers in the DTC (74%) and control (62%) groups. ISI showed no difference in subjects without clinically significant insomnia: DTC (43%) and controls (48%). ThyPRO showed significantly worse scores in DTC than control subjects. In DTC patients, PSQI (
P
= 0.002) and ISI (
P
= 0.04) correlated significantly with age. In control subjects, TSH displayed a significant positive association with PSQI (
P
= 0.02) and ISI (
P
< 0.05). The ThyPRO general score correlated significantly with PSQI in DTC patients. In both groups, ISI correlated significantly with several ThyPRO scales and the ThyPRO general score. “Anxiety” and “emotional susceptibility” were the scales most significantly related with PSQI and ISI.
Conclusion
In disease-free DTC patients and subjects who undergo thyroid surgery for benign pathology, abnormal sleep components and insomnia are similar. The ThyPRO questionnaire closely reflects sleep disturbances in all subjects. Recognising and treating sleep disturbances might improve QoL.</description><subject>Cross-sectional studies</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Humanities and Social Sciences</subject><subject>Insomnia</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>multidisciplinary</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Science</subject><subject>Sleep</subject><subject>Sleep disorders</subject><subject>Surgery</subject><subject>Thyroid cancer</subject><subject>Thyroid carcinoma</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroxine</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kU1rFTEUhgdRbK3-ARcScONmNJ-TmY1QilWh4EbBXchNTnpTZia3SaZy-1v8sT112vqxkBASOM_7npO8TfOS0beMUv2uME45bdetBtZeP2oOmVJDS7H-GO9CqZbS_vtB86yUC0o5551-2hwIoYQelDpsfh4Tl6adzbbGKyAup1LaAq7GNNuRlLr4PUkzKSPAjlwudox1T-JMdiiAuRbyI9YtsWQbS00Z2UB8DAEyFqOt4End7nOKnjibXZzTZImdPYkodSlnGO1tr9Xm3h9NxhjgefMk2LHAi7vzqPl2-uHryaf27MvHzyfHZ62TWtZWeepBDiE43okNU4I7y3thcSnHZOCgPNNWB6Z1Dzp0oaMiCMf9hvMN7cRR83713S2bCbzD0bMdzS7Hyea9STaavytz3JrzdGV6bCgVQ4M3dwY5XS5QqplicTCOdoa0FMNl38lOKy0Rff0PepGWjH-NlJIDF5J2PVJ8pX4FkiE8DMOouQ3frOGbdWP45hpFr_58xoPkPm0ExAoULM3nkH_3_o_tDZ_Hv7U</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Teliti, Marsida</creator><creator>Monti, Eleonora</creator><creator>Comina, Martina</creator><creator>Conte, Lucia</creator><creator>Vera, Lara</creator><creator>Gay, Stefano</creator><creator>Saccomani, Giorgia</creator><creator>Ferone, Diego</creator><creator>Giusti, Massimo</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1410-6143</orcidid></search><sort><creationdate>20210801</creationdate><title>A comparative cross-sectional study on sleep quality in patients with a history of differentiated thyroid carcinoma and its correlation with quality of life</title><author>Teliti, Marsida ; Monti, Eleonora ; Comina, Martina ; Conte, Lucia ; Vera, Lara ; Gay, Stefano ; Saccomani, Giorgia ; Ferone, Diego ; Giusti, Massimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-5d0de49ffc263b1532ca283a3a35c14f2e5d17a7f1778e7f6f603f3c2db22b063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cross-sectional studies</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Humanities and Social Sciences</topic><topic>Insomnia</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>multidisciplinary</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Quality of life</topic><topic>Questionnaires</topic><topic>Science</topic><topic>Sleep</topic><topic>Sleep disorders</topic><topic>Surgery</topic><topic>Thyroid cancer</topic><topic>Thyroid carcinoma</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyroxine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teliti, Marsida</creatorcontrib><creatorcontrib>Monti, Eleonora</creatorcontrib><creatorcontrib>Comina, Martina</creatorcontrib><creatorcontrib>Conte, Lucia</creatorcontrib><creatorcontrib>Vera, Lara</creatorcontrib><creatorcontrib>Gay, Stefano</creatorcontrib><creatorcontrib>Saccomani, Giorgia</creatorcontrib><creatorcontrib>Ferone, Diego</creatorcontrib><creatorcontrib>Giusti, Massimo</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teliti, Marsida</au><au>Monti, Eleonora</au><au>Comina, Martina</au><au>Conte, Lucia</au><au>Vera, Lara</au><au>Gay, Stefano</au><au>Saccomani, Giorgia</au><au>Ferone, Diego</au><au>Giusti, Massimo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative cross-sectional study on sleep quality in patients with a history of differentiated thyroid carcinoma and its correlation with quality of life</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>73</volume><issue>2</issue><spage>347</spage><epage>357</epage><pages>347-357</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Purpose
To evaluate sleep quality in differentiated thyroid carcinoma (DTC) patients and correlate sleep disturbances with quality of life (QoL).
Methods
119 DTC patients were enrolled (DTC group). The Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI) inventories were administered. The Thyroid-specific Patient-Reported Outcome (ThyPRO) questionnaire, the Billewicz scale (BS) and an ad-hoc visual analogic scale (VAS) were used to measure QoL and subjective therapy-related complaints. The same examinations were conducted in 53 subjects (control group) who had undergone surgery for benign thyroid pathology.
Results
L-T4 dosages and TSH levels differed between the groups. BS and VAS scores were comparable. PSQI documented a similar percentage of poor sleepers in the DTC (74%) and control (62%) groups. ISI showed no difference in subjects without clinically significant insomnia: DTC (43%) and controls (48%). ThyPRO showed significantly worse scores in DTC than control subjects. In DTC patients, PSQI (
P
= 0.002) and ISI (
P
= 0.04) correlated significantly with age. In control subjects, TSH displayed a significant positive association with PSQI (
P
= 0.02) and ISI (
P
< 0.05). The ThyPRO general score correlated significantly with PSQI in DTC patients. In both groups, ISI correlated significantly with several ThyPRO scales and the ThyPRO general score. “Anxiety” and “emotional susceptibility” were the scales most significantly related with PSQI and ISI.
Conclusion
In disease-free DTC patients and subjects who undergo thyroid surgery for benign pathology, abnormal sleep components and insomnia are similar. The ThyPRO questionnaire closely reflects sleep disturbances in all subjects. Recognising and treating sleep disturbances might improve QoL.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33537955</pmid><doi>10.1007/s12020-020-02591-z</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1410-6143</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Endocrine, 2021-08, Vol.73 (2), p.347-357 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Cross-sectional studies Diabetes Endocrinology Humanities and Social Sciences Insomnia Internal Medicine Medicine Medicine & Public Health multidisciplinary Original Original Article Patients Quality of life Questionnaires Science Sleep Sleep disorders Surgery Thyroid cancer Thyroid carcinoma Thyroid-stimulating hormone Thyroxine |
| title | A comparative cross-sectional study on sleep quality in patients with a history of differentiated thyroid carcinoma and its correlation with quality of life |
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