Staphylococcal Protein A Induces Leukocyte Necrosis by Complexing with Human Immunoglobulins

One of the defining features of Staphylococcus aureus is its ability to evade and impair the human immune response through expression of staphylococcal protein A (SpA). Herein, we describe a previously unknown mechanism by which SpA can form toxic immune complexes when in the presence of human serum...

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Veröffentlicht in:	mBio 2021-06, Vol.12 (3), p.e0089921, Article 00899
Hauptverfasser:	Fox, Proinnsias G., Schiavetti, Francesca, Rappuoli, Rino, McLoughlin, Rachel M., Bagnoli, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Antibody Complex B-Lymphocytes - drug effects B-Lymphocytes - pathology Cell Line, Tumor Female Humans Immunoglobulin G - immunology Immunoglobulin G - metabolism Immunoglobulin G - pharmacology Life Sciences & Biomedicine Mice Mice, Inbred BALB C Microbiology Necrosis - immunology Research Article Science & Technology Staphylococcal Protein A - administration & dosage Staphylococcal Protein A - immunology Staphylococcal Protein A - pharmacology Staphylococcus aureus - metabolism Vaccination
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