Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

Selective targeting of aneuploid cells is an attractive strategy for cancer treatment 1 . However, it is unclear whether aneuploidy generates any clinically relevant vulnerabilities in cancer cells. Here we mapped the aneuploidy landscapes of about 1,000 human cancer cell lines, and analysed genetic...

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Veröffentlicht in:	Nature (London) 2021-02, Vol.590 (7846), p.486-491
Hauptverfasser:	Cohen-Sharir, Yael, McFarland, James M., Abdusamad, Mai, Marquis, Carolyn, Bernhard, Sara V., Kazachkova, Mariya, Tang, Helen, Ippolito, Marica R., Laue, Kathrin, Zerbib, Johanna, Malaby, Heidi L. H., Jones, Andrew, Stautmeister, Lisa-Marie, Bockaj, Irena, Wardenaar, René, Lyons, Nicholas, Nagaraja, Ankur, Bass, Adam J., Spierings, Diana C. J., Foijer, Floris, Beroukhim, Rameen, Santaguida, Stefano, Golub, Todd R., Stumpff, Jason, Storchová, Zuzana, Ben-David, Uri
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 14/63 38/39 38/89 45/23 45/91 631/67/68 631/67/69 Abnormal Karyotype - drug effects Aneuploidy Cancer Cancer cells Cell cycle Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chromosome Segregation - drug effects Chromosomes Datasets Depletion Diploids Diploidy Genes Genes, Lethal Genetic analysis Genetic aspects Genomes Humanities and Social Sciences Humans Karyotypes Kinesin Kinesins - deficiency Kinesins - genetics Kinesins - metabolism M Phase Cell Cycle Checkpoints - drug effects Mitosis multidisciplinary Neoplasms - genetics Neoplasms - pathology Perturbation Science Science (multidisciplinary) Spindle Apparatus - drug effects Synthetic Lethal Mutations - drug effects Synthetic Lethal Mutations - genetics Time Factors Tumor cell lines
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