Adult zebrafish ventricular electrical gradients as tissue mechanisms of ECG patterns under baseline vs. oxidative stress

Abstract Aims In mammalian ventricles, electrical gradients establish electrical heterogeneities as essential tissue mechanisms to optimize mechanical efficiency and safeguard electrical stability. Electrical gradients shape mammalian electrocardiographic patterns; disturbance of electrical gradient...

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Veröffentlicht in:	Cardiovascular research 2021-07, Vol.117 (8), p.1891-1907
Hauptverfasser:	Zhao, Yali, James, Nicholas A, Beshay, Ashraf R, Chang, Eileen E, Lin, Andrew, Bashar, Faiza, Wassily, Abram, Nguyen, Binh, Nguyen, Thao P
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - physiopathology Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Electrocardiography Enzyme Activation Female Heart Rate - drug effects Heart Ventricles - drug effects Heart Ventricles - metabolism Heart Ventricles - physiopathology Hydrogen Peroxide - toxicity Male Original Oxidative Stress - drug effects Voltage-Sensitive Dye Imaging Zebrafish - embryology Zebrafish - metabolism
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