Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations
BACKGROUNDThe coronavirus disease 2019 (COVID-19) rapidly progressed to a global pandemic. Although some patients totally recover from COVID-19 pneumonia, the disease's long-term effects on the brain still need to be explored.METHODSWe recruited 51 patients with 2 subtypes of COVID-19 (19 mild...
Gespeichert in:
| Veröffentlicht in: | The Journal of clinical investigation 2021-04, Vol.131 (8) |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | |
| container_title | The Journal of clinical investigation |
| container_volume | 131 |
| creator | Qin, Yuanyuan Wu, Jinfeng Chen, Tao Li, Jia Zhang, Guiling Wu, Di Zhou, Yiran Zheng, Ning Cai, Aoling Ning, Qin Manyande, Anne Xu, Fuqiang Wang, Jie Zhu, Wenzhen |
| description | BACKGROUNDThe coronavirus disease 2019 (COVID-19) rapidly progressed to a global pandemic. Although some patients totally recover from COVID-19 pneumonia, the disease's long-term effects on the brain still need to be explored.METHODSWe recruited 51 patients with 2 subtypes of COVID-19 (19 mild and 32 severe) with no specific neurological manifestations at the acute stage and no obvious lesions on the conventional MRI 3 months after discharge. Changes in gray matter morphometry, cerebral blood flow (CBF), and white matter (WM) microstructure were investigated using MRI. The relationship between brain imaging measurements and inflammation markers was further analyzed.RESULTSCompared with healthy controls, the decrease in cortical thickness/CBF and the changes in WM microstructure were more severe in patients with severe disease than in those with mild disease, especially in the frontal and limbic systems. Furthermore, changes in brain microstructure, CBF, and tract parameters were significantly correlated (P < 0.05) with the inflammatory markers C-reactive protein, procalcitonin, and interleukin 6.CONCLUSIONIndirect injury related to inflammatory storm may damage the brain, altering cerebral volume, CBF, and WM tracts. COVID-19-related hypoxemia and dysfunction of vascular endothelium may also contribute to neurological changes. The abnormalities in these brain areas need to be monitored during recovery, which could help clinicians understand the potential neurological sequelae of COVID-19.FUNDINGNatural Science Foundation of China. |
| doi_str_mv | 10.1172/JCI147329 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8262559</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A659258535</galeid><sourcerecordid>A659258535</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-4255e82ef4711c91de4d3fbf96748d7aeea70047b82a65a275f8b0ead14316f83</originalsourceid><addsrcrecordid>eNpVkTuP1DAUhSMEYoeFgj-AXKGlCPgZ2w3SangNGmkboLWc5OaBHHuwnV3R8dPxMMsIqlv487nn3FNVzwl-TYikbz5vd4RLRvWDakOEULWiTD2sNhhTUmvJ1EX1JKXvGBPOBX9cXTDWMCwbvKl-7YMf6wxxQcvcxZByXLu8RkDW96iDCG20DrUuhB4NLtyhbrJ-hIRmjw42z-BzQhG6cFvYgsSwoO3Nt927mmh0N-cprBl5WGNwYZy7orVYPw-QcvkcfHpaPRqsS_Dsfl5WXz-8_7L9VO9vPu621_u647jJNadCgKIwcElIp0kPvGdDO-hGctVLC2Alxly2itpGWCrFoFoMtieckWZQ7LJ6e9I9rO0CfVd8l2DmEOfFxp8m2Nn8_-LnyYzh1ijalN26CFzdC8TwYy3-zTKnDpyzHsKaDOWaUy2pPqIvT-hoHZgJrMtTCm79E9hcN0JToQQTBXx1Ao-XTxGGsx-CzbFac662sC_-DXAm_3bJfgOQiaEL</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2494297299</pqid></control><display><type>article</type><title>Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Qin, Yuanyuan ; Wu, Jinfeng ; Chen, Tao ; Li, Jia ; Zhang, Guiling ; Wu, Di ; Zhou, Yiran ; Zheng, Ning ; Cai, Aoling ; Ning, Qin ; Manyande, Anne ; Xu, Fuqiang ; Wang, Jie ; Zhu, Wenzhen</creator><creatorcontrib>Qin, Yuanyuan ; Wu, Jinfeng ; Chen, Tao ; Li, Jia ; Zhang, Guiling ; Wu, Di ; Zhou, Yiran ; Zheng, Ning ; Cai, Aoling ; Ning, Qin ; Manyande, Anne ; Xu, Fuqiang ; Wang, Jie ; Zhu, Wenzhen</creatorcontrib><description>BACKGROUNDThe coronavirus disease 2019 (COVID-19) rapidly progressed to a global pandemic. Although some patients totally recover from COVID-19 pneumonia, the disease's long-term effects on the brain still need to be explored.METHODSWe recruited 51 patients with 2 subtypes of COVID-19 (19 mild and 32 severe) with no specific neurological manifestations at the acute stage and no obvious lesions on the conventional MRI 3 months after discharge. Changes in gray matter morphometry, cerebral blood flow (CBF), and white matter (WM) microstructure were investigated using MRI. The relationship between brain imaging measurements and inflammation markers was further analyzed.RESULTSCompared with healthy controls, the decrease in cortical thickness/CBF and the changes in WM microstructure were more severe in patients with severe disease than in those with mild disease, especially in the frontal and limbic systems. Furthermore, changes in brain microstructure, CBF, and tract parameters were significantly correlated (P < 0.05) with the inflammatory markers C-reactive protein, procalcitonin, and interleukin 6.CONCLUSIONIndirect injury related to inflammatory storm may damage the brain, altering cerebral volume, CBF, and WM tracts. COVID-19-related hypoxemia and dysfunction of vascular endothelium may also contribute to neurological changes. The abnormalities in these brain areas need to be monitored during recovery, which could help clinicians understand the potential neurological sequelae of COVID-19.FUNDINGNatural Science Foundation of China.</description><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/JCI147329</identifier><identifier>PMID: 33630760</identifier><language>eng</language><publisher>United States: American Society for Clinical Investigation</publisher><subject>Aged ; Blood flow ; Brain - blood supply ; Brain - diagnostic imaging ; Brain - pathology ; C-Reactive Protein - metabolism ; Case-Control Studies ; Cerebrovascular Circulation - physiology ; China - epidemiology ; Clinical Medicine ; COVID-19 - diagnostic imaging ; COVID-19 - epidemiology ; COVID-19 - physiopathology ; Diffusion Tensor Imaging ; Echo-Planar Imaging ; Evaluation ; Female ; Follow-Up Studies ; Gray Matter - diagnostic imaging ; Gray Matter - pathology ; Health aspects ; Humans ; Imaging, Three-Dimensional ; Inflammation Mediators - blood ; Interleukin-6 - blood ; Male ; Middle Aged ; Neuroimaging ; Pandemics ; Procalcitonin - blood ; Prognosis ; SARS-CoV-2 ; Severity of Illness Index ; Time Factors ; White Matter - diagnostic imaging ; White Matter - pathology</subject><ispartof>The Journal of clinical investigation, 2021-04, Vol.131 (8)</ispartof><rights>COPYRIGHT 2021 American Society for Clinical Investigation</rights><rights>2021 American Society for Clinical Investigation 2021 American Society for Clinical Investigation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-4255e82ef4711c91de4d3fbf96748d7aeea70047b82a65a275f8b0ead14316f83</citedby><cites>FETCH-LOGICAL-c406t-4255e82ef4711c91de4d3fbf96748d7aeea70047b82a65a275f8b0ead14316f83</cites><orcidid>0000-0002-0673-3200</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262559/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262559/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33630760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qin, Yuanyuan</creatorcontrib><creatorcontrib>Wu, Jinfeng</creatorcontrib><creatorcontrib>Chen, Tao</creatorcontrib><creatorcontrib>Li, Jia</creatorcontrib><creatorcontrib>Zhang, Guiling</creatorcontrib><creatorcontrib>Wu, Di</creatorcontrib><creatorcontrib>Zhou, Yiran</creatorcontrib><creatorcontrib>Zheng, Ning</creatorcontrib><creatorcontrib>Cai, Aoling</creatorcontrib><creatorcontrib>Ning, Qin</creatorcontrib><creatorcontrib>Manyande, Anne</creatorcontrib><creatorcontrib>Xu, Fuqiang</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Zhu, Wenzhen</creatorcontrib><title>Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>BACKGROUNDThe coronavirus disease 2019 (COVID-19) rapidly progressed to a global pandemic. Although some patients totally recover from COVID-19 pneumonia, the disease's long-term effects on the brain still need to be explored.METHODSWe recruited 51 patients with 2 subtypes of COVID-19 (19 mild and 32 severe) with no specific neurological manifestations at the acute stage and no obvious lesions on the conventional MRI 3 months after discharge. Changes in gray matter morphometry, cerebral blood flow (CBF), and white matter (WM) microstructure were investigated using MRI. The relationship between brain imaging measurements and inflammation markers was further analyzed.RESULTSCompared with healthy controls, the decrease in cortical thickness/CBF and the changes in WM microstructure were more severe in patients with severe disease than in those with mild disease, especially in the frontal and limbic systems. Furthermore, changes in brain microstructure, CBF, and tract parameters were significantly correlated (P < 0.05) with the inflammatory markers C-reactive protein, procalcitonin, and interleukin 6.CONCLUSIONIndirect injury related to inflammatory storm may damage the brain, altering cerebral volume, CBF, and WM tracts. COVID-19-related hypoxemia and dysfunction of vascular endothelium may also contribute to neurological changes. The abnormalities in these brain areas need to be monitored during recovery, which could help clinicians understand the potential neurological sequelae of COVID-19.FUNDINGNatural Science Foundation of China.</description><subject>Aged</subject><subject>Blood flow</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>China - epidemiology</subject><subject>Clinical Medicine</subject><subject>COVID-19 - diagnostic imaging</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - physiopathology</subject><subject>Diffusion Tensor Imaging</subject><subject>Echo-Planar Imaging</subject><subject>Evaluation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gray Matter - diagnostic imaging</subject><subject>Gray Matter - pathology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Inflammation Mediators - blood</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuroimaging</subject><subject>Pandemics</subject><subject>Procalcitonin - blood</subject><subject>Prognosis</subject><subject>SARS-CoV-2</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>White Matter - diagnostic imaging</subject><subject>White Matter - pathology</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkTuP1DAUhSMEYoeFgj-AXKGlCPgZ2w3SangNGmkboLWc5OaBHHuwnV3R8dPxMMsIqlv487nn3FNVzwl-TYikbz5vd4RLRvWDakOEULWiTD2sNhhTUmvJ1EX1JKXvGBPOBX9cXTDWMCwbvKl-7YMf6wxxQcvcxZByXLu8RkDW96iDCG20DrUuhB4NLtyhbrJ-hIRmjw42z-BzQhG6cFvYgsSwoO3Nt927mmh0N-cprBl5WGNwYZy7orVYPw-QcvkcfHpaPRqsS_Dsfl5WXz-8_7L9VO9vPu621_u647jJNadCgKIwcElIp0kPvGdDO-hGctVLC2Alxly2itpGWCrFoFoMtieckWZQ7LJ6e9I9rO0CfVd8l2DmEOfFxp8m2Nn8_-LnyYzh1ijalN26CFzdC8TwYy3-zTKnDpyzHsKaDOWaUy2pPqIvT-hoHZgJrMtTCm79E9hcN0JToQQTBXx1Ao-XTxGGsx-CzbFac662sC_-DXAm_3bJfgOQiaEL</recordid><startdate>20210415</startdate><enddate>20210415</enddate><creator>Qin, Yuanyuan</creator><creator>Wu, Jinfeng</creator><creator>Chen, Tao</creator><creator>Li, Jia</creator><creator>Zhang, Guiling</creator><creator>Wu, Di</creator><creator>Zhou, Yiran</creator><creator>Zheng, Ning</creator><creator>Cai, Aoling</creator><creator>Ning, Qin</creator><creator>Manyande, Anne</creator><creator>Xu, Fuqiang</creator><creator>Wang, Jie</creator><creator>Zhu, Wenzhen</creator><general>American Society for Clinical Investigation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0673-3200</orcidid></search><sort><creationdate>20210415</creationdate><title>Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations</title><author>Qin, Yuanyuan ; Wu, Jinfeng ; Chen, Tao ; Li, Jia ; Zhang, Guiling ; Wu, Di ; Zhou, Yiran ; Zheng, Ning ; Cai, Aoling ; Ning, Qin ; Manyande, Anne ; Xu, Fuqiang ; Wang, Jie ; Zhu, Wenzhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-4255e82ef4711c91de4d3fbf96748d7aeea70047b82a65a275f8b0ead14316f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Blood flow</topic><topic>Brain - blood supply</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>C-Reactive Protein - metabolism</topic><topic>Case-Control Studies</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>China - epidemiology</topic><topic>Clinical Medicine</topic><topic>COVID-19 - diagnostic imaging</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - physiopathology</topic><topic>Diffusion Tensor Imaging</topic><topic>Echo-Planar Imaging</topic><topic>Evaluation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gray Matter - diagnostic imaging</topic><topic>Gray Matter - pathology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Inflammation Mediators - blood</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuroimaging</topic><topic>Pandemics</topic><topic>Procalcitonin - blood</topic><topic>Prognosis</topic><topic>SARS-CoV-2</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><topic>White Matter - diagnostic imaging</topic><topic>White Matter - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qin, Yuanyuan</creatorcontrib><creatorcontrib>Wu, Jinfeng</creatorcontrib><creatorcontrib>Chen, Tao</creatorcontrib><creatorcontrib>Li, Jia</creatorcontrib><creatorcontrib>Zhang, Guiling</creatorcontrib><creatorcontrib>Wu, Di</creatorcontrib><creatorcontrib>Zhou, Yiran</creatorcontrib><creatorcontrib>Zheng, Ning</creatorcontrib><creatorcontrib>Cai, Aoling</creatorcontrib><creatorcontrib>Ning, Qin</creatorcontrib><creatorcontrib>Manyande, Anne</creatorcontrib><creatorcontrib>Xu, Fuqiang</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Zhu, Wenzhen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qin, Yuanyuan</au><au>Wu, Jinfeng</au><au>Chen, Tao</au><au>Li, Jia</au><au>Zhang, Guiling</au><au>Wu, Di</au><au>Zhou, Yiran</au><au>Zheng, Ning</au><au>Cai, Aoling</au><au>Ning, Qin</au><au>Manyande, Anne</au><au>Xu, Fuqiang</au><au>Wang, Jie</au><au>Zhu, Wenzhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>2021-04-15</date><risdate>2021</risdate><volume>131</volume><issue>8</issue><issn>0021-9738</issn><eissn>1558-8238</eissn><abstract>BACKGROUNDThe coronavirus disease 2019 (COVID-19) rapidly progressed to a global pandemic. Although some patients totally recover from COVID-19 pneumonia, the disease's long-term effects on the brain still need to be explored.METHODSWe recruited 51 patients with 2 subtypes of COVID-19 (19 mild and 32 severe) with no specific neurological manifestations at the acute stage and no obvious lesions on the conventional MRI 3 months after discharge. Changes in gray matter morphometry, cerebral blood flow (CBF), and white matter (WM) microstructure were investigated using MRI. The relationship between brain imaging measurements and inflammation markers was further analyzed.RESULTSCompared with healthy controls, the decrease in cortical thickness/CBF and the changes in WM microstructure were more severe in patients with severe disease than in those with mild disease, especially in the frontal and limbic systems. Furthermore, changes in brain microstructure, CBF, and tract parameters were significantly correlated (P < 0.05) with the inflammatory markers C-reactive protein, procalcitonin, and interleukin 6.CONCLUSIONIndirect injury related to inflammatory storm may damage the brain, altering cerebral volume, CBF, and WM tracts. COVID-19-related hypoxemia and dysfunction of vascular endothelium may also contribute to neurological changes. The abnormalities in these brain areas need to be monitored during recovery, which could help clinicians understand the potential neurological sequelae of COVID-19.FUNDINGNatural Science Foundation of China.</abstract><cop>United States</cop><pub>American Society for Clinical Investigation</pub><pmid>33630760</pmid><doi>10.1172/JCI147329</doi><orcidid>https://orcid.org/0000-0002-0673-3200</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9738 |
| ispartof | The Journal of clinical investigation, 2021-04, Vol.131 (8) |
| issn | 0021-9738 1558-8238 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8262559 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged Blood flow Brain - blood supply Brain - diagnostic imaging Brain - pathology C-Reactive Protein - metabolism Case-Control Studies Cerebrovascular Circulation - physiology China - epidemiology Clinical Medicine COVID-19 - diagnostic imaging COVID-19 - epidemiology COVID-19 - physiopathology Diffusion Tensor Imaging Echo-Planar Imaging Evaluation Female Follow-Up Studies Gray Matter - diagnostic imaging Gray Matter - pathology Health aspects Humans Imaging, Three-Dimensional Inflammation Mediators - blood Interleukin-6 - blood Male Middle Aged Neuroimaging Pandemics Procalcitonin - blood Prognosis SARS-CoV-2 Severity of Illness Index Time Factors White Matter - diagnostic imaging White Matter - pathology |
| title | Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T03%3A44%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20microstructure%20and%20cerebral%20blood%20flow%20changes%20in%20patients%20recovered%20from%20COVID-19%20without%20neurological%20manifestations&rft.jtitle=The%20Journal%20of%20clinical%20investigation&rft.au=Qin,%20Yuanyuan&rft.date=2021-04-15&rft.volume=131&rft.issue=8&rft.issn=0021-9738&rft.eissn=1558-8238&rft_id=info:doi/10.1172/JCI147329&rft_dat=%3Cgale_pubme%3EA659258535%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2494297299&rft_id=info:pmid/33630760&rft_galeid=A659258535&rfr_iscdi=true |