Enhanced Catecholamine Flux and Impaired Carbonyl Metabolism Disrupt Cardiac Mitochondrial Oxidative Phosphorylation in Diabetes Patients

Catecholamine metabolism monoamine oxidase (MAO) contributes to cardiac injury in models of ischemia and diabetes, but the pathogenic mechanisms involved are unclear. MAO deaminates norepinephrine (NE) and dopamine to produce H O and highly reactive "catecholaldehydes," which may be toxic...

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Veröffentlicht in:	Antioxidants & redox signaling 2021-08, Vol.35 (4), p.235-251
Hauptverfasser:	Nelson, Margaret-Ann M, Efird, Jimmy T, Kew, Kimberly A, Katunga, Lalage A, Monroe, T Blake, Doorn, Jonathan A, Beatty, Cherese N, Shi, Qian, Akhter, Shahab A, Alwair, Hazaim, Robidoux, Jacques, Anderson, Ethan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Aldehyde dehydrogenase Aldehyde Dehydrogenase - metabolism Aldehydes Amine oxidase (flavin-containing) Autophagy (Ed. Sihem Boudina)—Part B Body mass Body mass index Body size Carbonyl compounds Carbonyls Catechol Catecholamine Catecholamines Catecholamines - metabolism Coronary artery disease Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Dopamine Drug therapy Forum Original Research Communication Heart diseases Humans Hydrogen peroxide Ischemia Localization Metabolism Metabolites Metabolomics Mitochondria Mitochondria, Heart - metabolism Monoamine Oxidase - genetics Monoamine Oxidase - metabolism Myocardium Norepinephrine Oxidation-Reduction Oxidative metabolism Oxidative phosphorylation Patients Phosphorylation Protein adducts Proteins Tissue analysis Toxicity
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