Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

The symptom of heavy menstrual bleeding (HMB) diminishes quality-of-life for many mid-age women and imposes substantial societal burden. We investigated our hypothesis that HMB reflects impaired endometrial vasoconstriction due to endometrial glucocorticoid deficiency. Does reversing this deficiency...

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Veröffentlicht in:	EBioMedicine 2021-07, Vol.69, p.103434, Article 103434
Hauptverfasser:	Warner, Pamela, Whitaker, Lucy Harriet Ravenscroft, Parker, Richard Anthony, Weir, Christopher John, Douglas, Anne, Hansen, Christian Holm, Madhra, Mayank, Hillier, Stephen Gilbert, Saunders, Philippa Tansy Kemp, Iredale, John Peter, Semple, Scott, Slayden, Ov Daniel, Walker, Brian Robert, Critchley, Hilary Octavia Dawn
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormal uterine bleeding (AUB) Adaptive randomisation Adult Bayesian Dexamethasone Dexamethasone - administration & dosage Dexamethasone - therapeutic use Endometrium Endometrium - blood supply Female General & Internal Medicine Glucocorticoids - administration & dosage Glucocorticoids - therapeutic use Heavy menstrual bleeding (HMB) Humans Life Sciences & Biomedicine Medicine, General & Internal Medicine, Research & Experimental Menorrhagia Menorrhagia - drug therapy Menorrhagia - physiopathology Middle Aged Randomised controlled trial Research & Experimental Medicine Research Paper Science & Technology Vasoconstriction
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