Optogenetic Control of Non‐Apoptotic Cell Death: Optogenetic Control of Non‐Apoptotic Cell Death (Adv. Sci. 13/2021)
In article number 2100424, Gang Han, Yubin Zhou, Ji Jing, and co‐workers introduce a set of optogenetic tools, designated LiPOPs, that enable photoswitchable control over key molecular steps involved in necroptosis or pyroptosis, including cell membrane perforation, extracellular ions influx, and ce...
Gespeichert in:
| Veröffentlicht in: | Advanced science 2021-07, Vol.8 (13), p.n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 13 |
| container_start_page | |
| container_title | Advanced science |
| container_volume | 8 |
| creator | He, Lian Huang, Zixian Huang, Kai Chen, Rui Nguyen, Nhung T. Wang, Rui Cai, Xiaoli Huang, Zhiquan Siwko, Stefan Walker, Joel R. Han, Gang Zhou, Yubin Jing, Ji |
| description | In article number 2100424, Gang Han, Yubin Zhou, Ji Jing, and co‐workers introduce a set of optogenetic tools, designated LiPOPs, that enable photoswitchable control over key molecular steps involved in necroptosis or pyroptosis, including cell membrane perforation, extracellular ions influx, and cell suicide. LiPOPs are coupled with either upconversion nanoparticles (UCNPs) with NIR‐to‐blue emission (left corner) or NanoLuc‐catalyzed bioluminescence‐based optogenetic stimulation (NanoLOGS; right corner) to achieve wireless nano‐optogenetic or chemo‐optogenetic manipulation of cell fate with high spatiotemporal precision in living animals. LiPOPs open new avenues to study the role of non‐apoptotic cell death during microbial infection, inflammatory response and cancer immunotherapy. |
| doi_str_mv | 10.1002/advs.202170080 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_24P</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8261510</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ADVS202170080</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1840-2dfb2438620bff6735c9ec60c54f60a24e596eb92c20d62702f8955f0513da493</originalsourceid><addsrcrecordid>eNqVkL1OwzAUhS0EElXpyuwRhqTXjp04DEhRy59U0aHAajmO3QalcZSEQjcegWfkSUgpKjAhpnulc76jo4PQMQGfANChylaNT4GSCEDAHupREgsvEIzt__gP0aBpHgGA8CBiRPTQy7Rq3dyUps01HrmyrV2BncW3rnx_fUsq18mfkikKPDaqXZzhfyP4JMlWPp7p3MckGG5qnh6hA6uKxgy-bh_dX17cja69yfTqZpRMPE0EA49mNqUsECGF1NowCriOjQ5Bc2ZDUJQZHocmjammkIU0AmpFzLkFToJMsTjoo_NtbvWULk2mTddXFbKq86Wq19KpXP5Wynwh524lBQ0JJ9AF-NsAXbumqY3dsQTkZnu52V7utu-AeAs854VZ_-GWyfhh9s1-AB5IifU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Optogenetic Control of Non‐Apoptotic Cell Death: Optogenetic Control of Non‐Apoptotic Cell Death (Adv. Sci. 13/2021)</title><source>Wiley Online Library (Open Access Collection)</source><creator>He, Lian ; Huang, Zixian ; Huang, Kai ; Chen, Rui ; Nguyen, Nhung T. ; Wang, Rui ; Cai, Xiaoli ; Huang, Zhiquan ; Siwko, Stefan ; Walker, Joel R. ; Han, Gang ; Zhou, Yubin ; Jing, Ji</creator><creatorcontrib>He, Lian ; Huang, Zixian ; Huang, Kai ; Chen, Rui ; Nguyen, Nhung T. ; Wang, Rui ; Cai, Xiaoli ; Huang, Zhiquan ; Siwko, Stefan ; Walker, Joel R. ; Han, Gang ; Zhou, Yubin ; Jing, Ji</creatorcontrib><description>In article number 2100424, Gang Han, Yubin Zhou, Ji Jing, and co‐workers introduce a set of optogenetic tools, designated LiPOPs, that enable photoswitchable control over key molecular steps involved in necroptosis or pyroptosis, including cell membrane perforation, extracellular ions influx, and cell suicide. LiPOPs are coupled with either upconversion nanoparticles (UCNPs) with NIR‐to‐blue emission (left corner) or NanoLuc‐catalyzed bioluminescence‐based optogenetic stimulation (NanoLOGS; right corner) to achieve wireless nano‐optogenetic or chemo‐optogenetic manipulation of cell fate with high spatiotemporal precision in living animals. LiPOPs open new avenues to study the role of non‐apoptotic cell death during microbial infection, inflammatory response and cancer immunotherapy.</description><identifier>ISSN: 2198-3844</identifier><identifier>EISSN: 2198-3844</identifier><identifier>DOI: 10.1002/advs.202170080</identifier><language>eng</language><publisher>Hoboken: John Wiley and Sons Inc</publisher><subject>Back Cover</subject><ispartof>Advanced science, 2021-07, Vol.8 (13), p.n/a</ispartof><rights>2021 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261510/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261510/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,865,886,1418,11567,27929,27930,45579,45580,46057,46481,53796,53798</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1002%2Fadvs.202170080$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc></links><search><creatorcontrib>He, Lian</creatorcontrib><creatorcontrib>Huang, Zixian</creatorcontrib><creatorcontrib>Huang, Kai</creatorcontrib><creatorcontrib>Chen, Rui</creatorcontrib><creatorcontrib>Nguyen, Nhung T.</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Cai, Xiaoli</creatorcontrib><creatorcontrib>Huang, Zhiquan</creatorcontrib><creatorcontrib>Siwko, Stefan</creatorcontrib><creatorcontrib>Walker, Joel R.</creatorcontrib><creatorcontrib>Han, Gang</creatorcontrib><creatorcontrib>Zhou, Yubin</creatorcontrib><creatorcontrib>Jing, Ji</creatorcontrib><title>Optogenetic Control of Non‐Apoptotic Cell Death: Optogenetic Control of Non‐Apoptotic Cell Death (Adv. Sci. 13/2021)</title><title>Advanced science</title><description>In article number 2100424, Gang Han, Yubin Zhou, Ji Jing, and co‐workers introduce a set of optogenetic tools, designated LiPOPs, that enable photoswitchable control over key molecular steps involved in necroptosis or pyroptosis, including cell membrane perforation, extracellular ions influx, and cell suicide. LiPOPs are coupled with either upconversion nanoparticles (UCNPs) with NIR‐to‐blue emission (left corner) or NanoLuc‐catalyzed bioluminescence‐based optogenetic stimulation (NanoLOGS; right corner) to achieve wireless nano‐optogenetic or chemo‐optogenetic manipulation of cell fate with high spatiotemporal precision in living animals. LiPOPs open new avenues to study the role of non‐apoptotic cell death during microbial infection, inflammatory response and cancer immunotherapy.</description><subject>Back Cover</subject><issn>2198-3844</issn><issn>2198-3844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqVkL1OwzAUhS0EElXpyuwRhqTXjp04DEhRy59U0aHAajmO3QalcZSEQjcegWfkSUgpKjAhpnulc76jo4PQMQGfANChylaNT4GSCEDAHupREgsvEIzt__gP0aBpHgGA8CBiRPTQy7Rq3dyUps01HrmyrV2BncW3rnx_fUsq18mfkikKPDaqXZzhfyP4JMlWPp7p3MckGG5qnh6hA6uKxgy-bh_dX17cja69yfTqZpRMPE0EA49mNqUsECGF1NowCriOjQ5Bc2ZDUJQZHocmjammkIU0AmpFzLkFToJMsTjoo_NtbvWULk2mTddXFbKq86Wq19KpXP5Wynwh524lBQ0JJ9AF-NsAXbumqY3dsQTkZnu52V7utu-AeAs854VZ_-GWyfhh9s1-AB5IifU</recordid><startdate>20210707</startdate><enddate>20210707</enddate><creator>He, Lian</creator><creator>Huang, Zixian</creator><creator>Huang, Kai</creator><creator>Chen, Rui</creator><creator>Nguyen, Nhung T.</creator><creator>Wang, Rui</creator><creator>Cai, Xiaoli</creator><creator>Huang, Zhiquan</creator><creator>Siwko, Stefan</creator><creator>Walker, Joel R.</creator><creator>Han, Gang</creator><creator>Zhou, Yubin</creator><creator>Jing, Ji</creator><general>John Wiley and Sons Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20210707</creationdate><title>Optogenetic Control of Non‐Apoptotic Cell Death: Optogenetic Control of Non‐Apoptotic Cell Death (Adv. Sci. 13/2021)</title><author>He, Lian ; Huang, Zixian ; Huang, Kai ; Chen, Rui ; Nguyen, Nhung T. ; Wang, Rui ; Cai, Xiaoli ; Huang, Zhiquan ; Siwko, Stefan ; Walker, Joel R. ; Han, Gang ; Zhou, Yubin ; Jing, Ji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1840-2dfb2438620bff6735c9ec60c54f60a24e596eb92c20d62702f8955f0513da493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Back Cover</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Lian</creatorcontrib><creatorcontrib>Huang, Zixian</creatorcontrib><creatorcontrib>Huang, Kai</creatorcontrib><creatorcontrib>Chen, Rui</creatorcontrib><creatorcontrib>Nguyen, Nhung T.</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Cai, Xiaoli</creatorcontrib><creatorcontrib>Huang, Zhiquan</creatorcontrib><creatorcontrib>Siwko, Stefan</creatorcontrib><creatorcontrib>Walker, Joel R.</creatorcontrib><creatorcontrib>Han, Gang</creatorcontrib><creatorcontrib>Zhou, Yubin</creatorcontrib><creatorcontrib>Jing, Ji</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advanced science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>He, Lian</au><au>Huang, Zixian</au><au>Huang, Kai</au><au>Chen, Rui</au><au>Nguyen, Nhung T.</au><au>Wang, Rui</au><au>Cai, Xiaoli</au><au>Huang, Zhiquan</au><au>Siwko, Stefan</au><au>Walker, Joel R.</au><au>Han, Gang</au><au>Zhou, Yubin</au><au>Jing, Ji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optogenetic Control of Non‐Apoptotic Cell Death: Optogenetic Control of Non‐Apoptotic Cell Death (Adv. Sci. 13/2021)</atitle><jtitle>Advanced science</jtitle><date>2021-07-07</date><risdate>2021</risdate><volume>8</volume><issue>13</issue><epage>n/a</epage><issn>2198-3844</issn><eissn>2198-3844</eissn><abstract>In article number 2100424, Gang Han, Yubin Zhou, Ji Jing, and co‐workers introduce a set of optogenetic tools, designated LiPOPs, that enable photoswitchable control over key molecular steps involved in necroptosis or pyroptosis, including cell membrane perforation, extracellular ions influx, and cell suicide. LiPOPs are coupled with either upconversion nanoparticles (UCNPs) with NIR‐to‐blue emission (left corner) or NanoLuc‐catalyzed bioluminescence‐based optogenetic stimulation (NanoLOGS; right corner) to achieve wireless nano‐optogenetic or chemo‐optogenetic manipulation of cell fate with high spatiotemporal precision in living animals. LiPOPs open new avenues to study the role of non‐apoptotic cell death during microbial infection, inflammatory response and cancer immunotherapy.</abstract><cop>Hoboken</cop><pub>John Wiley and Sons Inc</pub><doi>10.1002/advs.202170080</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 2198-3844 |
| ispartof | Advanced science, 2021-07, Vol.8 (13), p.n/a |
| issn | 2198-3844 2198-3844 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8261510 |
| source | Wiley Online Library (Open Access Collection) |
| subjects | Back Cover |
| title | Optogenetic Control of Non‐Apoptotic Cell Death: Optogenetic Control of Non‐Apoptotic Cell Death (Adv. Sci. 13/2021) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T08%3A27%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_24P&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Optogenetic%20Control%20of%20Non%E2%80%90Apoptotic%20Cell%20Death:%20Optogenetic%20Control%20of%20Non%E2%80%90Apoptotic%20Cell%20Death%20(Adv.%20Sci.%2013/2021)&rft.jtitle=Advanced%20science&rft.au=He,%20Lian&rft.date=2021-07-07&rft.volume=8&rft.issue=13&rft.epage=n/a&rft.issn=2198-3844&rft.eissn=2198-3844&rft_id=info:doi/10.1002/advs.202170080&rft_dat=%3Cwiley_24P%3EADVS202170080%3C/wiley_24P%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |